2. Gene
  3. Slc26a3 - solute carrier family 26, member 3 Gene

Slc26a3 - solute carrier family 26, member 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Dra; 9030623B18Rik; 9130013M11Rik

Gene ID: 13487 | Gene type: protein coding

About Slc26a3

Summary

This gene encodes a member of the solute carrier/sulfate transporter family. The encoded protein is predominantly expressed in the intestine where it is essential for chloride absorption. Disruption of this gene results in chloride-rich diarrhea and compensatory up-regulation of ion-absorbing transporters. [provided by RefSeq, Dec 2012]

Slc26a3 Products(1)

mRNA Protein Name
NM_021353.3 NP_067328.1 chloride anion exchanger
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables bicarbonate transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
21976599 MGI
enables chloride transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
21976599 MGI
enables chloride:bicarbonate antiporter activity IDA
IDA: Inferred from direct assay
10428871 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
21976599 MGI
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to cAMP IDA
IDA: Inferred from direct assay
21976599 MGI
involved in intracellular pH elevation IMP
IMP: Inferred from mutant phenotype
21976599 MGI
involved in membrane hyperpolarization IMP
IMP: Inferred from mutant phenotype
21976599 MGI
involved in sperm capacitation IMP
IMP: Inferred from mutant phenotype
21976599 MGI
Cellular Component GO Annotation Evidence Reference Source
located in membrane IDA
IDA: Inferred from direct assay
21976599 MGI
located in sperm midpiece IDA
IDA: Inferred from direct assay
21976599 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

chloride anion exchanger

down-regulated in adenoma

Slc26a3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Slc26a3 Q9WVC8 Nherf1 Mus musculus P70441
Anti Bait CoIP
21976599
Intra
Slc26a3 Q9WVC8 Slc26a6 Mus musculus Q8CIW6
Anti Bait CoIP
21976599
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-105028 Tenidap Inhibitor 99.32% Phase 3
Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-149276 SLC26A3-IN-2 99.88% Unkown
HY-159706 S9-A13 Inhibitor / Unkown
HY-RS13137 SLC26A3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-105028S Tenidap-d3 Inhibitor / Unkown
HY-128361 SLC26A3-IN-3 Inhibitor / Unkown
HY-149802 SLC26A3-IN-1 / Unkown
HY-105028A Tenidap sodium Inhibitor / Unkown
HY-RS19842 Slc26a3 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS26340 Slc26a3 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc26a3 NCBI NCBI:1811