Slc26a6 - solute carrier family 26, member 6 Gene

Mus musculus

Also known as CFEX; Pat1; Pat-1; B930010B04Rik

Gene ID: 171429 | Gene type: protein coding

About Slc26a6

Summary

Enables PDZ domain binding activity and anion transmembrane transporter activity. Involved in several processes, including anion transport; cellular response to cAMP; and cellular response to fructose stimulus. Located in several cellular components, including apical plasma membrane; brush border membrane; and sperm midpiece. Is integral component of plasma membrane. Orthologous to human SLC26A6 (solute carrier family 26 member 6). [provided by Alliance of Genome Resources, Apr 2022]

Slc26a6 Products(2)

mRNA	Protein	Name
NM_001408387.1	NP_001395316.1	solute carrier family 26 member 6 isoform 2
NM_134420.5	NP_599252.2	solute carrier family 26 member 6 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables PDZ domain binding	IDA IDA: Inferred from direct assay	16141316	MGI
enables bicarbonate transmembrane transporter activity	IDA IDA: Inferred from direct assay	11842009	MGI
enables chloride transmembrane transporter activity	IDA IDA: Inferred from direct assay	11459928	MGI
enables chloride transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	16141316	MGI
enables chloride:bicarbonate antiporter activity	IDA IDA: Inferred from direct assay	11842009	MGI
enables chloride:bicarbonate antiporter activity	IMP IMP: Inferred from mutant phenotype	20150244	MGI
enables efflux transmembrane transporter activity	IDA IDA: Inferred from direct assay	12217875	MGI
enables formate transmembrane transporter activity	IDA IDA: Inferred from direct assay	11459928	MGI
enables oxalate transmembrane transporter activity	IDA IDA: Inferred from direct assay	12217875	MGI
enables oxalate transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	16141316	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16141316	MGI
enables solute:inorganic anion antiporter activity	IDA IDA: Inferred from direct assay	11459928	MGI
enables solute:inorganic anion antiporter activity	IMP IMP: Inferred from mutant phenotype	16532010	MGI
enables sulfate transmembrane transporter activity	IDA IDA: Inferred from direct assay	12217875	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within bicarbonate transport	IDA IDA: Inferred from direct assay	11842009	MGI
involved in bicarbonate transport	IDA IDA: Inferred from direct assay	12119287	MGI
acts upstream of or within bicarbonate transport	IMP IMP: Inferred from mutant phenotype	19033647	MGI
involved in bicarbonate transport	IMP IMP: Inferred from mutant phenotype	20150244	MGI
involved in cellular response to cAMP	IDA IDA: Inferred from direct assay	22895259	MGI
involved in cellular response to fructose stimulus	IDA IDA: Inferred from direct assay	18496516	MGI
acts upstream of or within chloride transport	IDA IDA: Inferred from direct assay	11459928	MGI
involved in chloride transport	IDA IDA: Inferred from direct assay	12119287	MGI
involved in chloride transport	IMP IMP: Inferred from mutant phenotype	16141316	MGI
involved in epithelial fluid transport	IMP IMP: Inferred from mutant phenotype	18496516	MGI
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	19033647	MGI
acts upstream of or within formate transport	IDA IDA: Inferred from direct assay	11459928	MGI
involved in formate transport	IDA IDA: Inferred from direct assay	12119287	MGI
involved in formate transport	IMP IMP: Inferred from mutant phenotype	22895259	MGI
involved in intestinal absorption	IMP IMP: Inferred from mutant phenotype	22021714	MGI
involved in intracellular pH elevation	IMP IMP: Inferred from mutant phenotype	21976599	MGI
involved in mannitol transmembrane transport	IMP IMP: Inferred from mutant phenotype	22021714	MGI
involved in oxalate transport	IDA IDA: Inferred from direct assay	12119287	MGI
involved in oxalate transport	IMP IMP: Inferred from mutant phenotype	16141316	MGI
involved in oxalic acid secretion	IMP IMP: Inferred from mutant phenotype	22021714	MGI
involved in positive regulation of dipeptide transmembrane transport	IMP IMP: Inferred from mutant phenotype	20150244	MGI
involved in regulation of intracellular pH	IMP IMP: Inferred from mutant phenotype	20150244	MGI
involved in sperm capacitation	IMP IMP: Inferred from mutant phenotype	21976599	MGI
involved in sulfate transmembrane transport	IDA IDA: Inferred from direct assay	12119287	MGI
involved in sulfate transmembrane transport	IMP IMP: Inferred from mutant phenotype	16532010	MGI
involved in transepithelial chloride transport	IDA IDA: Inferred from direct assay	11459928	MGI
involved in transepithelial chloride transport	IMP IMP: Inferred from mutant phenotype	22895259	MGI
involved in transepithelial transport	IMP IMP: Inferred from mutant phenotype	16141316	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	11459928	MGI
located in brush border membrane	IDA IDA: Inferred from direct assay	11459928	MGI
located in membrane	IDA IDA: Inferred from direct assay	11842009	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	11459928	MGI
located in sperm midpiece	IDA IDA: Inferred from direct assay	21976599	MGI
located in vesicle	IDA IDA: Inferred from direct assay	11842009	MGI
located in vesicle membrane	IDA IDA: Inferred from direct assay	16141316	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

solute carrier family 26 member 6

anion exchange transporter	chloride-formate exchanger
pendrin-L1	pendrin-like protein 1
putative anion transporter-1

Slc26a6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Slc26a6	Q8CIW6	Cftr	Mus musculus	P26361	Confocal	21976599
Intra	Slc26a6	Q8CIW6	Slc26a3	Mus musculus	Q9WVC8	Anti Bait CoIP	21976599

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-154912	PAT1inh-B01	Inhibitor	98.32%	Unkown
HY-159706	S9-A13	Inhibitor	/	Unkown
HY-154912A	PAT1inh-B01 hydrochloride	Inhibitor	≥98.0%	Unkown
HY-162033	PAT1inh-A0030	Inhibitor	/	Unkown
HY-RS13140	SLC26A6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS22038	Slc26a6 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc26a6	NCBI	NCBI:65010

Name
Email *

	Sorry, but the email address you supplied was invalid.