Cdc42 - cell division cycle 42 Gene

Mus musculus

Gene ID: 12540 | Gene type: protein coding

About Cdc42

Summary

Enables several functions, including GTP-dependent protein binding activity; GTPase activity; and Rho GDP-dissociation inhibitor binding activity. Involved in several processes, including dendritic spine morphogenesis; heart development; and positive regulation of cellular component organization. Acts upstream of or within several processes, including cellular response to interferon-gamma; filopodium assembly; and positive regulation of phosphatidylinositol 3-kinase activity. Located in several cellular components, including leading edge membrane; phagocytic vesicle; and storage vacuole. Is active in cell leading edge. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and immune system. Used to study microvillus inclusion disease. Human ortholog(s) of this gene implicated in fibrosarcoma. Orthologous to human CDC42 (cell division cycle 42). [provided by Alliance of Genome Resources, Apr 2022]

Cdc42 Products(2)

mRNA	Protein	Name
NM_001243769.1	NP_001230698.1	cell division control protein 42 homolog isoform 2
NM_009861.3	NP_033991.1	cell division control protein 42 homolog isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTP-dependent protein binding	IPI IPI: Inferred from physical interaction	10954424	MGI
enables GTPase activity	IDA IDA: Inferred from direct assay	10699171	MGI
enables GTPase activity	IGI IGI: Inferred from genetic interaction	18838382	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8464478	MGI
enables protein kinase binding	IPI IPI: Inferred from physical interaction	21048939	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within adherens junction organization	IMP IMP: Inferred from mutant phenotype	16892058	MGI
acts upstream of or within cardiac conduction system development	IGI IGI: Inferred from genetic interaction	21690310	MGI
involved in cardiac neural crest cell migration involved in outflow tract morphogenesis	IMP IMP: Inferred from mutant phenotype	31219639	MGI
acts upstream of or within cellular response to type II interferon	IDA IDA: Inferred from direct assay	19144319	MGI
acts upstream of or within dendritic cell migration	IGI IGI: Inferred from genetic interaction	22461490	MGI
involved in dendritic spine morphogenesis	IMP IMP: Inferred from mutant phenotype	25851601	MGI
involved in embryonic heart tube development	IMP IMP: Inferred from mutant phenotype	31219639	MGI
acts upstream of or within endocytosis	IMP IMP: Inferred from mutant phenotype	24792215	MGI
involved in endothelin receptor signaling pathway involved in heart process	IMP IMP: Inferred from mutant phenotype	31219639	MGI
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	24792215	MGI
acts upstream of or within establishment or maintenance of apical/basal cell polarity	IMP IMP: Inferred from mutant phenotype	16892058	MGI
acts upstream of or within filopodium assembly	IDA IDA: Inferred from direct assay	10699171	MGI
acts upstream of or within heart contraction	IGI IGI: Inferred from genetic interaction	21690310	MGI
involved in heart process	IMP IMP: Inferred from mutant phenotype	25197047	MGI
acts upstream of or within neuron fate determination	IMP IMP: Inferred from mutant phenotype	16892058	MGI
acts upstream of or within nuclear migration	IMP IMP: Inferred from mutant phenotype	15882626	MGI
acts upstream of or within nucleus localization	IMP IMP: Inferred from mutant phenotype	16892058	MGI
acts upstream of or within positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	19244314	MGI
involved in positive regulation of epithelial cell proliferation involved in lung morphogenesis	IMP IMP: Inferred from mutant phenotype	23219958	MGI
involved in positive regulation of filopodium assembly	IMP IMP: Inferred from mutant phenotype	22494997	MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	15728722	MGI
involved in positive regulation of pinocytosis	IMP IMP: Inferred from mutant phenotype	24792215	MGI
acts upstream of or within protein localization	IMP IMP: Inferred from mutant phenotype	16621792	MGI
involved in protein phosphorylation	IMP IMP: Inferred from mutant phenotype	31219639	MGI
acts upstream of or within regulation of mitotic nuclear division	IMP IMP: Inferred from mutant phenotype	16892058	MGI
involved in regulation of postsynapse organization	IDA IDA: Inferred from direct assay	25851601	MGI
involved in regulation of postsynapse organization	IMP IMP: Inferred from mutant phenotype	25851601	MGI
acts upstream of or within regulation of protein binding	IDA IDA: Inferred from direct assay	19244314	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical part of cell	IDA IDA: Inferred from direct assay	16892058	MGI
is active in cell leading edge	IDA IDA: Inferred from direct assay	31219639	MGI
located in cell periphery	IDA IDA: Inferred from direct assay	19796622	MGI
located in cell projection	IDA IDA: Inferred from direct assay	15728722	MGI
located in cell-cell junction	IDA IDA: Inferred from direct assay	23793062	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	15775979	MGI
located in cytosol	IDA IDA: Inferred from direct assay	21828338	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	25851601	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	25851601	MGI
located in leading edge membrane	IDA IDA: Inferred from direct assay	22461490	MGI
located in phagocytic vesicle	IDA IDA: Inferred from direct assay	19144319	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	21828338	MGI
is active in postsynapse	IDA IDA: Inferred from direct assay	33531495	MGI
is active in postsynapse	IMP IMP: Inferred from mutant phenotype	33531495	MGI
located in storage vacuole	IDA IDA: Inferred from direct assay	21828338	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cell division control protein 42 homolog

G25K GTP-binding protein

cell division cycle 42 homolog

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-I0400	N-Acetylneuraminic acid		99.90%	Phase 1
HY-112842	MBQ-167	Inhibitor	99.64%	Phase 1

Pre-clinical Phase

Bioactive Molecules (35)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12755	ML141		99.96%	Unkown
HY-12646	Rhosin hydrochloride		99.93%	Unkown
HY-12874	CASIN		99.89%	Unkown
HY-12810	EHop-016	Inhibitor	99.85%	Unkown
HY-111424	BDP9066	Inhibitor	98.18%	Unkown
HY-13963	ZCL278	Inhibitor	98.49%	Unkown
HY-N0710	alpha-Cyperone		99.68%	Unkown
HY-115376	Z62954982	Inhibitor	99.38%	Unkown
HY-136379	CID44216842	Inhibitor	99.84%	Unkown
HY-113849	MLS-573151	Inhibitor	99.70%	Unkown
HY-136383	AZA1		98.07%	Unkown
HY-10943	GNF-7	Inhibitor	99.70%	Unkown
HY-B0580B	(R)-Ketorolac	Inhibitor	99.65%	Unkown
HY-149464	ARN22089	Inhibitor	98.73%	Unkown
HY-15031	l-Naproxen	Inhibitor	99.63%	Unkown
HY-111424A	(R)-BDP9066	Inhibitor	98.49%	Unkown
HY-RS02300	CDC42 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-116269	AZA197		98.28%	Unkown
HY-152095	PPI-GIT1/β-Pix interaction-IN-1	Inhibitor	99.01%	Unkown
HY-12646A	Rhosin		95.08%	Unkown
HY-111423	BDP8900	Inhibitor	/	Unkown
HY-149921	Antiangiogenic agent 3	Inhibitor	/	Unkown
HY-161736	ARN25499	Inhibitor	/	Unkown
HY-170327	ZCL279	Inhibitor	/	Unkown
HY-172917	Rho GTPase inhibitor 1	Inhibitor	/	Unkown
HY-RS02301	CDC42BPA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS02302	CDC42BPB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS02303	CDC42EP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS02304	CDC42EP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS02305	CDC42EP4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-167828	ARN25062	Inhibitor	/	Unkown
HY-D2415	BODIPY-FL staurosporine		/	Unkown
HY-N15267	Ovalitenone	Inhibitor	/	Unkown
HY-RS16681	Cdc42 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23116	Cdc42 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cdc42	NCBI	NCBI:998

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