2. Gene
  3. C5ar1 - complement component 5a receptor 1 Gene

C5ar1 - complement component 5a receptor 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as C5aR; C5r1; Cd88; D7Msu1

Gene ID: 12273 | Gene type: protein coding

About C5ar1

Summary

Enables complement component C5a receptor activity. Involved in several processes, including astrocyte activation; positive regulation of vascular endothelial growth factor production; and regulation of granulocyte chemotaxis. Acts upstream of or within defense response to Gram-positive bacterium; neutrophil chemotaxis; and response to peptidoglycan. Predicted to be located in several cellular components, including apical part of cell; basolateral plasma membrane; and cell surface. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; liver; neural ectoderm; and sensory organ. Orthologous to several human genes including OPRPN (opiorphin prepropeptide). [provided by Alliance of Genome Resources, Apr 2022]

C5ar1 Products(2)

mRNA Protein Name
NM_001173550.1 NP_001167021.1 C5a anaphylatoxin chemotactic receptor 1
NM_007577.4 NP_031603.2 C5a anaphylatoxin chemotactic receptor 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables complement component C5a receptor activity IDA
IDA: Inferred from direct assay
1401897 MGI
Biological Process GO Annotation Evidence Reference Source
involved in amyloid-beta clearance IGI
IGI: Inferred from genetic interaction
19561098 MGI
involved in astrocyte activation IGI
IGI: Inferred from genetic interaction
19561098 MGI
involved in cognition IGI
IGI: Inferred from genetic interaction
19561098 MGI
acts upstream of or within defense response to Gram-positive bacterium IMP
IMP: Inferred from mutant phenotype
17114491 MGI
involved in microglial cell activation IGI
IGI: Inferred from genetic interaction
19561098 MGI
acts upstream of or within neutrophil chemotaxis IMP
IMP: Inferred from mutant phenotype
17114491 MGI
involved in positive regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
16452172 MGI
involved in positive regulation of macrophage chemotaxis IMP
IMP: Inferred from mutant phenotype
16452172 MGI
involved in positive regulation of neutrophil chemotaxis IMP
IMP: Inferred from mutant phenotype
16452172 MGI
involved in positive regulation of vascular endothelial growth factor production IMP
IMP: Inferred from mutant phenotype
16452172 MGI
involved in presynapse organization IGI
IGI: Inferred from genetic interaction
19561098 MGI
involved in regulation of tau-protein kinase activity IGI
IGI: Inferred from genetic interaction
19561098 MGI
acts upstream of or within response to peptidoglycan IMP
IMP: Inferred from mutant phenotype
17114491 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

C5a anaphylatoxin chemotactic receptor 1

C5a anaphylatoxin receptor

C5a ligand

C5a-R

complement component 5, receptor 1

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-106178 PMX-53 Antagonist 99.98% Phase 2
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99450 Avdoralimab Inhibitor 99.25% Phase 2
Pre-clinical Phase
Bioactive Molecules (11)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-110136A PMX 205 Trifluoroacetate Antagonist 99.50% Unkown
HY-148141 JPE-1375 Antagonist 99.96% Unkown
HY-145237 BM213 Agonist 99.81% Unkown
HY-P10639 C5aR2 agonist P32 Agonist 99.82% Unkown
HY-163378 C5aR1 antagonist 1 Antagonist / Unkown
HY-163379 C5aR1 antagonist 2 Antagonist / Unkown
HY-RS01750 C5AR1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-P10639A C5aR2 agonist P32 acetate Agonist / Unkown
HY-RS18377 C5ar1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24857 C5ar1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W130878 4-Octylphenol Activator / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990745 Izastobart Ligand / Unkown
HY-P991485 Anti-CD88/C5AR1 Antibody (G2_anti-C5aR) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens C5ar1 NCBI NCBI:728