Klf5 - Kruppel-like factor 5 Gene

Mus musculus

Also known as CKLF; IKLF; Bteb2; 4930520J07Rik

Gene ID: 12224 | Gene type: protein coding

About Klf5

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; MRF binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; regulation of transcription, DNA-templated; and skeletal muscle tissue regeneration. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including early conceptus; genitourinary system; gut; respiratory system; and sensory organ. Orthologous to human KLF5 (Kruppel like factor 5). [provided by Alliance of Genome Resources, Apr 2022]

Klf5 Products(1)

mRNA	Protein	Name
NM_009769.4	NP_033899.2	Krueppel-like factor 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	12101409	MGI
enables DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	12101409	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	27743478	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IGI IGI: Inferred from genetic interaction	27743478	MGI
enables MRF binding	IPI IPI: Inferred from physical interaction	27743478	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	27743478	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IGI IGI: Inferred from genetic interaction	27743478	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12101409	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within angiogenesis	IMP IMP: Inferred from mutant phenotype	12101409	MGI
acts upstream of or within cellular response to leukemia inhibitory factor	IEP IEP: Inferred from expression pattern	20439489	MGI
acts upstream of or within intestinal epithelial cell development	IMP IMP: Inferred from mutant phenotype	23266329	MGI
acts upstream of microvillus assembly	IMP IMP: Inferred from mutant phenotype	12101409	MGI
acts upstream of or within myotube differentiation involved in skeletal muscle regeneration	IDA IDA: Inferred from direct assay	27743478	MGI
acts upstream of or within myotube differentiation involved in skeletal muscle regeneration	IMP IMP: Inferred from mutant phenotype	27743478	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	23266329	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	12101409	MGI
acts upstream of or within positive regulation of fat cell differentiation	IMP IMP: Inferred from mutant phenotype	20719859	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	27743478	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	27743478	MGI
acts upstream of or within positive regulation of transcription by transcription factor localization	IDA IDA: Inferred from direct assay	27743478	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	27743478	MGI
acts upstream of regulation of microvillus assembly	IMP IMP: Inferred from mutant phenotype	23266329	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	23266329	MGI
acts upstream of or within satellite cell activation involved in skeletal muscle regeneration	IMP IMP: Inferred from mutant phenotype	27743478	MGI
acts upstream of or within skeletal muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	22147266	MGI
acts upstream of or within skeletal muscle satellite cell differentiation	IMP IMP: Inferred from mutant phenotype	27743478	MGI
acts upstream of or within skeletal muscle tissue regeneration	IMP IMP: Inferred from mutant phenotype	27743478	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	21503901	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	27743478	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

Krueppel-like factor 5

BTE-binding protein 2	basic transcription element-binding protein 2
intestinal-enriched krueppel-like factor	transcription factor BTEB2

Klf5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Klf5	Q9Z0Z7	FBXW7	Homo sapiens	Q969H0	Anti Tag CoIP	22307056

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19994	ML264	Inhibitor	98.32%	Unkown
HY-136530	SR18662	Inhibitor	99.61%	Unkown
HY-N1570	Pterosin B	Inhibitor	99.92%	Unkown
HY-W011044	CID 5951923	Inhibitor	99.00%	Unkown
HY-139691	SR15006	Inhibitor	99.95%	Unkown
HY-RS07342	KLF5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-162875	PROTAC BRD4 Degrader-27		/	Unkown
HY-169213	LN-439A	Inhibitor	/	Unkown
HY-RS16676	Klf5 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23111	Klf5 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Klf5	NCBI	NCBI:688

Name
Email *

	Sorry, but the email address you supplied was invalid.