Axin2 - axin 2 Gene

Mus musculus

Also known as Axi1; Axil; Conductin

Gene ID: 12006 | Gene type: protein coding

About Axin2

Summary

Enables I-SMAD binding activity and ubiquitin protein Ligase binding activity. Involved in regulation of centromeric sister chromatid cohesion. Acts upstream of or within several processes, including animal organ development; negative regulation of osteoblast differentiation; and regulation of chondrocyte development. Located in centrosome and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Used to study craniosynostosis. Human ortholog(s) of this gene implicated in colorectal Cancer and endometrial adenocarcinoma. Orthologous to human AXIN2 (axin 2). [provided by Alliance of Genome Resources, Apr 2022]

Axin2 Products(1)

mRNA	Protein	Name
NM_015732.4	NP_056547.3	axin-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables I-SMAD binding	IPI IPI: Inferred from physical interaction	16601693	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9554852	MGI
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	16601693	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in aortic valve morphogenesis	IMP IMP: Inferred from mutant phenotype	28069701	MGI
acts upstream of or within bone mineralization	IMP IMP: Inferred from mutant phenotype	19623616	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15790973	MGI
acts upstream of or within chondrocyte differentiation involved in endochondral bone morphogenesis	IMP IMP: Inferred from mutant phenotype	19623616	MGI
acts upstream of or within intramembranous ossification	IMP IMP: Inferred from mutant phenotype	15790973	MGI
involved in mitral valve morphogenesis	IMP IMP: Inferred from mutant phenotype	28069701	MGI
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	28069701	MGI
acts upstream of or within negative regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	15790973	MGI
acts upstream of or within negative regulation of osteoblast proliferation	IMP IMP: Inferred from mutant phenotype	15790973	MGI
acts upstream of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	15790973	MGI
acts upstream of osteoblast proliferation	IMP IMP: Inferred from mutant phenotype	15790973	MGI
acts upstream of or within regulation of Wnt signaling pathway	IDA IDA: Inferred from direct assay	9554852	MGI
involved in regulation of centromeric sister chromatid cohesion	IMP IMP: Inferred from mutant phenotype	20300119	MGI
acts upstream of or within regulation of chondrocyte development	IMP IMP: Inferred from mutant phenotype	19623616	MGI
involved in regulation of extracellular matrix organization	IMP IMP: Inferred from mutant phenotype	28069701	MGI
acts upstream of or within secondary heart field specification	IGI IGI: Inferred from genetic interaction	22711842	MGI
acts upstream of or within somitogenesis	IDA IDA: Inferred from direct assay	12636920	MGI
acts upstream of or within stem cell proliferation	IMP IMP: Inferred from mutant phenotype	20569694	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in centrosome	IDA IDA: Inferred from direct assay	20300119	MGI
located in nucleus	IDA IDA: Inferred from direct assay	21991325	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

axin-2

axin-like protein

axis inhibition protein 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-123851	MSC2504877	Inhibitor	98.50%	Unkown
HY-112799	DK419	Inhibitor	99.86%	Unkown
HY-163767	Antitumor agent-171	Inhibitor	98.48%	Unkown
HY-108516	TC-E 5001	Inhibitor	/	Unkown
HY-148918	E722-2648	Inhibitor	/	Unkown
HY-RS01292	AXIN2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20863	Axin2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27378	Axin2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991311	GSK3178022	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Axin2	NCBI	NCBI:8313

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