Tirap - toll-interleukin 1 receptor (TIR) domain-containing adaptor protein Gene

Mus musculus

Also known as Mal; Wyatt; Tlr4ap; C130027E04Rik

Gene ID: 117149 | Gene type: protein coding

About Tirap

Summary

Enables Toll-like Receptor 2 binding activity; identical protein binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including positive regulation of B cell proliferation; positive regulation of NF-kappaB transcription factor activity; and regulation of cytokine production. Acts upstream of or within several processes, including I-kappaB kinase/NF-kappaB signaling; myeloid cell differentiation; and response to bacterium. Located in endocytic vesicle and ruffle membrane. Is expressed in testis. Human ortholog(s) of this gene implicated in malaria and tuberculosis. Orthologous to human TIRAP (TIR domain containing adaptor protein). [provided by Alliance of Genome Resources, Apr 2022]

Tirap Products(4)

mRNA	Protein	Name
NM_001177845.1	NP_001171316.1	toll/interleukin-1 receptor domain-containing adapter protein
NM_001177846.1	NP_001171317.1	toll/interleukin-1 receptor domain-containing adapter protein
NM_001177847.1	NP_001171318.1	toll/interleukin-1 receptor domain-containing adapter protein
NM_054096.2	NP_473437.2	toll/interleukin-1 receptor domain-containing adapter protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables Toll-like receptor 2 binding	IPI IPI: Inferred from physical interaction	17322885	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	11544529	MGI
enables phosphatidylinositol-4,5-bisphosphate binding	IDA IDA: Inferred from direct assay	16751103	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11544529	MGI
enables signaling adaptor activity	IMP IMP: Inferred from mutant phenotype	11526399	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cell surface receptor signaling pathway	IPI IPI: Inferred from physical interaction	11526399	MGI
acts upstream of or within cellular response to bacterial lipopeptide	IMP IMP: Inferred from mutant phenotype	15690042	MGI
acts upstream of or within cellular response to lipoteichoic acid	IMP IMP: Inferred from mutant phenotype	15690042	MGI
acts upstream of or within defense response to Gram-positive bacterium	IMP IMP: Inferred from mutant phenotype	15690042	MGI
NOT involved in interleukin-1-mediated signaling pathway	IDA IDA: Inferred from direct assay	11544529	MGI
acts upstream of macrophage cytokine production	IMP IMP: Inferred from mutant phenotype	15690042	MGI
acts upstream of or within myeloid cell differentiation	IMP IMP: Inferred from mutant phenotype	11526399	MGI
involved in positive regulation of B cell proliferation	IMP IMP: Inferred from mutant phenotype	12447442	MGI
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	12447442	MGI
involved in positive regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	11526399	MGI
involved in positive regulation of chemokine (C-X-C motif) ligand 1 production	IMP IMP: Inferred from mutant phenotype	16301656	MGI
involved in positive regulation of chemokine (C-X-C motif) ligand 2 production	IMP IMP: Inferred from mutant phenotype	16301656	MGI
involved in positive regulation of innate immune response	IMP IMP: Inferred from mutant phenotype	16301656	MGI
involved in positive regulation of interleukin-12 production	IMP IMP: Inferred from mutant phenotype	12447442	MGI
involved in positive regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	12421970	MGI
involved in positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	12447442	MGI
involved in positive regulation of interleukin-8 production	IMP IMP: Inferred from mutant phenotype	16301656	MGI
acts upstream of or within positive regulation of macrophage cytokine production	IMP IMP: Inferred from mutant phenotype	15690042	MGI
involved in positive regulation of neutrophil chemotaxis	IMP IMP: Inferred from mutant phenotype	18039275	MGI
involved in positive regulation of toll-like receptor 3 signaling pathway	IDA IDA: Inferred from direct assay	17322885	MGI
acts upstream of or within positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	15690042	MGI
involved in positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	12447442	MGI
involved in regulation of interferon-beta production	IDA IDA: Inferred from direct assay	14630816	MGI
involved in regulation of interleukin-15 production	IMP IMP: Inferred from mutant phenotype	18583567	MGI
involved in toll-like receptor 4 signaling pathway	IMP IMP: Inferred from mutant phenotype	11526399	MGI
NOT involved in toll-like receptor 5 signaling pathway	IMP IMP: Inferred from mutant phenotype	12447442	MGI
acts upstream of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	15690042	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in endocytic vesicle	IDA IDA: Inferred from direct assay	16751103	MGI
NOT located in peroxisome	IDA IDA: Inferred from direct assay	20451243	MGI
located in ruffle membrane	IDA IDA: Inferred from direct assay	16751103	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

toll/interleukin-1 receptor domain-containing adapter protein

TIR domain-containing adapter protein	Toll-like receptor 4 adaptor protein
adaptor protein Wyatt	myD88 adapter-like protein

Tirap Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Tirap	Q99JY1	Pik3ap1	Mus musculus	Q9EQ32	Anti Tag CoIP	22187460

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14551	TIRAP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19486	Tirap Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25980	Tirap Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tirap	NCBI	NCBI:114609

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