Akap3 - A kinase (PRKA) anchor protein 3 Gene

Mus musculus

Also known as Prka3

Gene ID: 11642 | Gene type: protein coding

About Akap3

Summary

Enables protein kinase A binding activity. Acts upstream of or within blastocyst hatching; protein localization; and transmembrane receptor protein serine/threonine kinase signaling pathway. Located in acrosomal vesicle; sperm fibrous sheath; and sperm principal piece. Is expressed in early conceptus; secondary oocyte; and spermatocyte. Orthologous to human AKAP3 (A-kinase anchoring protein 3). [provided by Alliance of Genome Resources, Apr 2022]

Akap3 Products(1)

mRNA	Protein	Name
NM_009650.2	NP_033780.2	A-kinase anchor protein 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12606363	MGI
enables protein kinase A binding	IMP IMP: Inferred from mutant phenotype	10319321	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within blastocyst hatching	IMP IMP: Inferred from mutant phenotype	27869233	MGI
acts upstream of or within cell surface receptor protein serine/threonine kinase signaling pathway	IPI IPI: Inferred from physical interaction	10319321	MGI
involved in establishment of protein localization	IMP IMP: Inferred from mutant phenotype	31969357	MGI
involved in flagellated sperm motility	IMP IMP: Inferred from mutant phenotype	31969357	MGI
acts upstream of or within protein localization	IMP IMP: Inferred from mutant phenotype	10319321	MGI
acts upstream of or within sperm motility	IMP IMP: Inferred from mutant phenotype	10319321	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in acrosomal vesicle	IDA IDA: Inferred from direct assay	11278869	MGI
located in motile cilium	IDA IDA: Inferred from direct assay	12606363	MGI
is active in sperm fibrous sheath	IDA IDA: Inferred from direct assay	31969357	MGI
located in sperm fibrous sheath	IDA IDA: Inferred from direct assay	16687649	MGI
located in sperm principal piece	IDA IDA: Inferred from direct assay	11278869	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

A-kinase anchor protein 3

A-kinase anchor protein 110 kDa	AKAP 110
AKAP-3	Protein kinase A-anchoring protein 3

Akap3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Akap3	O88987	Brap	Mus musculus	Q99MP8	IF	25820252

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00518	AKAP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Akap3	NCBI	NCBI:10566

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