Ahr - aryl-hydrocarbon receptor Gene

Mus musculus

Also known as Ah; In; Ahh; Ahre; bHLHe76

Gene ID: 11622 | Gene type: protein coding

About Ahr

Summary

The protein encoded by this gene is a ligand-activated helix-loop-helix transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing Enzymes such as Cytochrome P450. Before ligand binding, the encoded protein is sequestered in the cytoplasm; upon ligand binding, this protein moves to the nucleus and stimulates transcription of target genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

Ahr Products(2)

mRNA	Protein	Name
NM_001314027.1	NP_001300956.1	aryl hydrocarbon receptor isoform 2
NM_013464.4	NP_038492.1	aryl hydrocarbon receptor isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	1313028	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	1313028	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	18223155	MGI
enables E-box binding	IDA IDA: Inferred from direct assay	20106950	MGI
enables aryl hydrocarbon receptor binding	IPI IPI: Inferred from physical interaction	24001774	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	24001774	MGI
enables nuclear receptor activity	IDA IDA: Inferred from direct assay	1314586	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8657146	MGI
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	24001774	MGI
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	11230806	MGI
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	24001774	MGI
enables protein-folding chaperone binding	IPI IPI: Inferred from physical interaction	15581363	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	1605850	MGI
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28396409	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in B cell homeostasis	IMP IMP: Inferred from mutant phenotype	7732381	MGI
involved in T cell homeostasis	IMP IMP: Inferred from mutant phenotype	7732381	MGI
involved in blood circulation	IMP IMP: Inferred from mutant phenotype	10973493	MGI
involved in blood vessel development	IMP IMP: Inferred from mutant phenotype	10973493	MGI
involved in blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	10973493	MGI
involved in blood vessel remodeling	IMP IMP: Inferred from mutant phenotype	10973493	MGI
involved in branching involved in blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	10973493	MGI
involved in camera-type eye development	IMP IMP: Inferred from mutant phenotype	10973493	MGI
involved in cardiac left ventricle morphogenesis	IMP IMP: Inferred from mutant phenotype	14644620	MGI
involved in cell morphogenesis	IMP IMP: Inferred from mutant phenotype	10973493	MGI
involved in cellular response to 2,3,7,8-tetrachlorodibenzodioxine	IDA IDA: Inferred from direct assay	33436590	MGI
involved in cellular response to 3-methylcholanthrene	IDA IDA: Inferred from direct assay	1314586	MGI
involved in circadian regulation of gene expression	IDA IDA: Inferred from direct assay	20106950	MGI
involved in circumferential growth involved in left ventricle morphogenesis	IMP IMP: Inferred from mutant phenotype	14644620	MGI
acts upstream of or within gland development	IMP IMP: Inferred from mutant phenotype	12151645	MGI
involved in glomerulus morphogenesis	IMP IMP: Inferred from mutant phenotype	14644620	MGI
involved in immune system process	IMP IMP: Inferred from mutant phenotype	7732381	MGI
involved in kidney morphogenesis	IMP IMP: Inferred from mutant phenotype	14644620	MGI
involved in liver development	IMP IMP: Inferred from mutant phenotype	7732381	MGI
involved in lymphocyte homeostasis	IMP IMP: Inferred from mutant phenotype	7732381	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	20106950	MGI
involved in negative regulation of systemic arterial blood pressure	IMP IMP: Inferred from mutant phenotype	14644620	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18223155	MGI
involved in negative regulation of vasoconstriction	IMP IMP: Inferred from mutant phenotype	14644620	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	1313028	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	20106950	MGI
acts upstream of or within positive regulation of RNA polymerase II transcription preinitiation complex assembly	IDA IDA: Inferred from direct assay	8215422	MGI
involved in positive regulation of cell size	IMP IMP: Inferred from mutant phenotype	10973493	MGI
involved in positive regulation of growth rate	IMP IMP: Inferred from mutant phenotype	7732381	MGI
involved in post-embryonic hemopoiesis	IMP IMP: Inferred from mutant phenotype	8692887	MGI
acts upstream of or within prostate gland development	IMP IMP: Inferred from mutant phenotype	12151645	MGI
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	1314586	MGI
acts upstream of or within reproductive structure development	IMP IMP: Inferred from mutant phenotype	12151645	MGI
involved in response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	7961644	MGI
involved in spleen development	IMP IMP: Inferred from mutant phenotype	7732381	MGI
involved in transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	1314586	MGI
involved in vasculature development	IMP IMP: Inferred from mutant phenotype	16443691	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12215427	MGI
located in cytosol	IDA IDA: Inferred from direct assay	17569696	MGI
is active in nucleus	IDA IDA: Inferred from direct assay	33436590	MGI
located in nucleus	IDA IDA: Inferred from direct assay	1314586	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

aryl hydrocarbon receptor

ah receptor

dioxin receptor

Related Agents

Approval

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-109044	Tapinarof	Agonist	99.95%	Unkown
HY-N0178	Diosmin	Agonist	99.51%	Yes
HY-A0083	Methacholine chloride	Agonist	≥98.0%	Yes
HY-B0311	Carbidopa	Modulator	≥98.0%	Yes
HY-B0678	Metaxalone		99.77%	Unkown
HY-17357	Nepafenac	Inhibitor	99.56%	Unkown
HY-W017113	2-Mercaptobenzothiazole	Activator	99.85%	Yes
HY-B0311A	Carbidopa monohydrate	Modulator	≥98.0%	Yes
HY-17479	Amfenac		/	Unkown
HY-A0083B	Methacholine bromide	Agonist	/	Unkown
HY-B0678R	Metaxalone (Standard)		/	Unkown

Clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Phase
HY-B2132	Tryptamine		99.77%	Phase 3
HY-15001	Stemregenin 1	Antagonist	99.95%	Phase 2
HY-N0170	Indole-3-carbinol		98.87%	Phase 2
HY-16031	AFP464 free base	Inhibitor	/	Phase 2
HY-111449	BAY-218	Antagonist	99.78%	Phase 1

Pre-clinical Phase

Bioactive Molecules (133)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12028	PD98059		99.94%	Unkown
HY-12684	CH-223191	Antagonist	99.96%	Unkown
HY-15484	Pifithrin-α hydrobromide		98.58%	Unkown
HY-12451	FICZ	Agonist	99.42%	Unkown
HY-W028393	Indole-3-pyruvic acid	Agonist	99.79%	Unkown
HY-135829	BAY 2416964	Antagonist	99.59%	Unkown
HY-19317	ITE	Agonist	99.27%	Unkown
HY-W007355	Skatole		99.98%	Unkown
HY-W015273A	trans-3-Indoleacrylic acid	Inhibitor	99.39%	Unkown
HY-102023	GNF351	Antagonist	99.87%	Unkown
HY-N1939	Icariside I		99.30%	Unkown
HY-114740	β-Naphthoflavone		99.94%	Unkown
HY-103220	6,2',4'-Trimethoxyflavone	Antagonist	98.02%	Unkown
HY-122208	SGA360	Inhibitor	99.93%	Unkown
HY-W011338	Benzyl butyl phthalate	Activator	≥97.0%	Unkown
HY-134217	KYN-101	Inhibitor	98.03%	Unkown
HY-135750	VAF347	Agonist	99.75%	Unkown
HY-W014502	D-Kynurenine	Agonist	99.67%	Unkown
HY-103221	MeBIO		≥98.0%	Unkown
HY-141609	IK-175	Inhibitor	99.78%	Unkown
HY-119019	ASB14780	Inhibitor	99.83%	Unkown
HY-144339	AhR agonist 2		99.89%	Unkown
HY-18619	YL-109	Modulator	99.26%	Unkown
HY-112628	CAY10464	Antagonist	99.77%	Unkown
HY-112629	PDM2	Antagonist	98.96%	Unkown
HY-B0845	Prochloraz		99.85%	Unkown
HY-W014075	1-Hydroxypyrene		99.84%	Unkown
HY-112627	CAY 10465	Agonist	98.30%	Unkown
HY-15001G	Stemregenin 1 (GMP)	Antagonist	/	Unkown
HY-12545	Brevetoxin-3	Activator	95.0%	Unkown
HY-117532	PenCB	Inducer	99.94%	Unkown
HY-N0914	Ajugol		99.13%	Unkown
HY-118438	10-Cl-BBQ	Agonist	99.48%	Unkown
HY-135831	AHR antagonist 2	Antagonist	99.30%	Unkown
HY-D0932	Sudan IV		≥98.0%	Unkown
HY-N4095	Brevifolincarboxylic acid	Inhibitor	99.90%	Unkown
HY-130256	β-NF-JQ1	Inhibitor	98.05%	Unkown
HY-124421	5F-203	Inducer	99.04%	Unkown
HY-77278	25-Hydroxytachysterol3	Agonist	98.89%	Unkown
HY-105791	Sulazepam		99.56%	Unkown
HY-111450	CB7993113	Antagonist	≥98.0%	Unkown
HY-117102	ANI-7	Activator	99.01%	Unkown
HY-N0586	Norisoboldine	Agonist	/	Unkown
HY-W011338S	Benzyl butyl phthalate-d4		98.38%	Unkown
HY-W014701	1,4-Dihydroxy-2-naphthoic acid	Activator	99.60%	Unkown
HY-111441	1,4-Chrysenequinone	Activator	98.42%	Unkown
HY-114682	Lenperone	Antagonist	98.11%	Unkown
HY-125019	iJak-381	Inhibitor	99.86%	Unkown
HY-17357S	Nepafenac-d5	Inhibitor	98.84%	Unkown
HY-N6264	26-Deoxyactein	Inhibitor	99.76%	Unkown
HY-W718300	Indole-3-pyruvic acid-d5		96.02%	Unkown
HY-100242	Mivotilate	Activator	99.58%	Unkown
HY-103223	Phortress	Inducer	99.25%	Unkown
HY-118780	CHD-5	Antagonist	≥98.0%	Unkown
HY-N0586A	Norisoboldine hydrochloride	Agonist	99.72%	Unkown
HY-N10123	Indolokine A5	Agonist	≥98.0%	Unkown
HY-RS00483	AHR Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W014075S	1-Hydroxypyrene-d9		99.95%	Unkown
HY-W764758	3-OH-Kynurenamine dihydroiodide	Activator	99.56%	Unkown
HY-136220	AHR antagonist 5	Antagonist	98.05%	Unkown
HY-104026CS	L-Kynurenine-13C10 sulfate hemihydrate	Agonist	99.90%	Unkown
HY-118474	GW 610	Activator	99.78%	Unkown
HY-16031B	AFP464 dihydrochloride	Inhibitor	99.67%	Unkown
HY-W046846	Corannulene	Agonist	≥97.0%	Unkown
HY-W338764	AHR agonist 3		99.79%	Unkown
HY-154825	20-Hydroxyvitamin D3		≥98.0%	Unkown
HY-B0973	Dibenzothiophene	Inhibitor	99.88%	Unkown
HY-N10295	Flavipin	Agonist	/	Unkown
HY-131340	LASSBio-1632	Inhibitor	/	Unkown
HY-136220A	AHR antagonist 5 hemimaleate	Antagonist	/	Unkown
HY-101802	Fluzinamide		/	Unkown
HY-103222	DiMNF	Modulator	98.01%	Unkown
HY-104026B	L-Kynurenine sulfate	Agonist	/	Unkown
HY-106487	Pridefine	Inhibitor	/	Unkown
HY-111157	Dezinamide		/	Unkown
HY-114682A	Lenperone hydrochloride	Antagonist	/	Unkown
HY-116148	AHR-11797		/	Unkown
HY-116638	AHR-5333	Inhibitor	/	Unkown
HY-116638A	AHR-5333 (mandelate)	Inhibitor	/	Unkown
HY-117774	AHR-2244 hydrochloride		/	Unkown
HY-118792	AHR activator 1		/	Unkown
HY-119018	AHR-6293	Inhibitor	/	Unkown
HY-119960	AHR-10037	Inhibitor	/	Unkown
HY-120377	CYP1A1 inhibitor 8a	Inhibitor	/	Unkown
HY-120677	AHR-15010	Inhibitor	/	Unkown
HY-123432	AHR-13268D	Inhibitor	/	Unkown
HY-123461	Sul-121 hydrochloride	Inhibitor	/	Unkown
HY-124021	Benzyl 2-naphthyl ether		/	Unkown
HY-125926S	2-Ketodoxapram-d5		/	Unkown
HY-129305	Tampramine fumarate	Inhibitor	/	Unkown
HY-130269	β-Naphthoflavone-CH2-OH		/	Unkown
HY-130270	AhR Ligand-Linker Conjugates 1		/	Unkown
HY-130842	β-Naphthoflavone-CH2-Br		/	Unkown
HY-135671	AhR modulator-1		/	Unkown
HY-135830	AHR antagonist 4	Antagonist	/	Unkown
HY-136891	AHR-16303B		/	Unkown
HY-139117	6,2′,4′-Trimethoxyflavone	Antagonist	/	Unkown
HY-155505	AHR agonist 4	Agonist	/	Unkown
HY-156908	3-OH-Kynurenamine	Activator	/	Unkown
HY-158167	AhR agonist 5	Agonist	/	Unkown
HY-158168	AhR agonist 6	Agonist	/	Unkown
HY-158169	AhR agonist 7	Agonist	/	Unkown
HY-161649	hCYP1B1-IN-2	Inhibitor	/	Unkown
HY-168033	AhR agonist 8	Agonist	/	Unkown
HY-169753	AHR-IN-1	Inhibitor	/	Unkown
HY-17479B	Amfenac sodium		/	Unkown
HY-19826	Isofistularin-3		/	Unkown
HY-A0083C	Methacholine iodide	Agonist	/	Unkown
HY-B0311AS	Carbidopa-d3 monohydrate	Modulator	≥98.0%	Unkown
HY-B0311D	Carbidopa hydrochloride	Modulator	/	Unkown
HY-B0311S1	Carbidopa-d3-1	Modulator	/	Unkown
HY-B0678S	Metaxalone-d3		≥98.0%	Unkown
HY-B0678S1	Metaxalone-d6		/	Unkown
HY-B0973S	Dibenzothiophene-d8	Inhibitor	/	Unkown
HY-N12537A	(2R,3S)-PD-1/PD-L1-IN-38		/	Unkown
HY-W014502R	D-Kynurenine (Standard)	Agonist	/	Unkown
HY-W517076	1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin	Agonist	/	Unkown
HY-W716464	Prochloraz-d7		/	Unkown
HY-101745	Rocastine	Antagonist	/	Unkown
HY-104026BS	L-Kynurenine-13C10 sulfate	Agonist	/	Unkown
HY-107063	AHR-1911	Activator	/	Unkown
HY-109044S	Tapinarof-d5	Agonist	/	Unkown
HY-118910	AHR-14310C	Antagonist	/	Unkown
HY-119991	AHR-9294	Inhibitor	/	Unkown
HY-125926S1	2-Ketodoxapram-d4		/	Unkown
HY-128229	AHR antagonist 6	Antagonist	/	Unkown
HY-130456	AHR 10718	Inhibitor	/	Unkown
HY-163665	AHR antagonist 8		/	Unkown
HY-170514	1,2,3,7,8,9-Hexachlorodibenzofuran	Ligand	/	Unkown
HY-D0932S	Sudan IV-d6		/	Unkown
HY-RS16533	Ahr Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22964	Ahr Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-U00010	Dazopride		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ahr	NCBI	NCBI:196

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