2. Gene
  3. Aga - aspartylglucosaminidase Gene

Aga - aspartylglucosaminidase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus
Gene ID: 11593 | Gene type: protein coding

About Aga

Summary

This gene encodes an amidase enzyme that participates in the breakdown of glycoproteins in the cell. The encoded protein undergoes proteolytic processing to generate a mature enzyme. Mice lacking the encoded protein exhibit accumulation of aspartylglucosamine along with lysosomal vacuolization, axonal swelling in the gracile nucleus and impaired neuromotor coordination. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Oct 2015]

Aga Products(2)

mRNA Protein Name
NM_001005847.2 NP_001005847.1 N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase isoform 1 preproprotein
NM_001205054.1 NP_001191983.1 N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase isoform 2 precursor
Protein Preferred Names Protein Names

N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase

N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase

glycosylasparaginase

Related Agents

Approval
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-132609 Patisiran sodium 99.09% Unkown
HY-108753 Eteplirsen 98.50% Unkown
Clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-143230 Custirsen 98.71% Phase 3
HY-132596 Tivanisiran Inhibitor 92.62% Phase 3
HY-147412 Ultevursen / Phase 3
HY-150724 ODN 1018 Agonist 96.23% Phase 2
HY-145726 ISIS 104838 Inhibitor / Phase 2
Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P1851A AGA-(C8R) HNG17, humanin derivative TFA 98.34% Unkown
HY-118528A TP0427736 hydrochloride Inhibitor 99.22% Unkown
HY-161618 MJ04 Inhibitor 98.08% Unkown
HY-170448 PROTAC AR Degrader-9 Degrader / Unkown
HY-170450 AR ligand-38 Ligand / Unkown
HY-P1851 AGA-(C8R) HNG17, humanin derivative / Unkown
HY-RS00436 AGA Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS17521 Aga Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23977 Aga Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aga NCBI NCBI:175
Rattus norvegicus Aga NCBI NCBI:290923