Asic1 - acid-sensing (proton-gated) ion channel 1 Gene

Mus musculus

Also known as ASIC; Accn2; BNaC2; ASIC1a; ASIC1b; B530003N02Rik

Gene ID: 11419 | Gene type: protein coding

About Asic1

Summary

Enables acid-sensing ion channel activity and ion gated channel activity. Acts upstream of or within several processes, including behavioral fear response; learning or memory; and response to amphetamine. Located in synapse. Is integral component of plasma membrane. Is expressed in several structures, including brain. Orthologous to human ASIC1 (acid sensing ion channel subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Asic1 Products(2)

mRNA	Protein	Name
NM_001289791.2	NP_001276720.1	acid-sensing ion channel 1 isoform 2
NM_009597.2	NP_033727.1	acid-sensing ion channel 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables monoatomic cation channel activity	IDA IDA: Inferred from direct assay	11854527	MGI
enables monoatomic cation channel activity	IMP IMP: Inferred from mutant phenotype	11854527	MGI
enables monoatomic ion-gated channel activity	IDA IDA: Inferred from direct assay	14960591	MGI
enables monoatomic ion-gated channel activity	IMP IMP: Inferred from mutant phenotype	14960591	MGI
enables pH-gated monoatomic ion channel activity	IDA IDA: Inferred from direct assay	21036899	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	18287010	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within associative learning	IMP IMP: Inferred from mutant phenotype	11988176	MGI
acts upstream of or within behavioral fear response	IMP IMP: Inferred from mutant phenotype	25828470	MGI
acts upstream of or within calcium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	19376200	MGI
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	14960591	MGI
acts upstream of or within memory	IMP IMP: Inferred from mutant phenotype	11988176	MGI
acts upstream of or within monoatomic cation transport	IDA IDA: Inferred from direct assay	11854527	MGI
acts upstream of or within monoatomic cation transport	IMP IMP: Inferred from mutant phenotype	11854527	MGI
acts upstream of or within monoatomic ion transmembrane transport	IDA IDA: Inferred from direct assay	14960591	MGI
acts upstream of or within monoatomic ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	14960591	MGI
acts upstream of or within negative regulation of neurotransmitter secretion	IMP IMP: Inferred from mutant phenotype	18094106	MGI
acts upstream of neurotransmitter secretion	IMP IMP: Inferred from mutant phenotype	18094106	MGI
acts upstream of or within regulation of membrane potential	IMP IMP: Inferred from mutant phenotype	19376200	MGI
involved in regulation of postsynapse assembly	IDA IDA: Inferred from direct assay	17060608	MGI
involved in regulation of postsynapse assembly	IMP IMP: Inferred from mutant phenotype	17060608	MGI
acts upstream of or within response to acidic pH	IDA IDA: Inferred from direct assay	11854527	MGI
acts upstream of or within response to acidic pH	IMP IMP: Inferred from mutant phenotype	11854527	MGI
acts upstream of or within response to amphetamine	IMP IMP: Inferred from mutant phenotype	25828470	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	17060608	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	17060608	MGI
is active in plasma membrane	IDA IDA: Inferred from direct assay	21036899	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	11854527	MGI
located in synapse	IDA IDA: Inferred from direct assay	11988176	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

acid-sensing ion channel 1

amiloride-sensitive cation channel 2, neuronal	brain sodium channel 2
degenerin 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1411	Psalmotoxin 1		99.02%	Unkown
HY-131879	NS383		99.83%	Unkown
HY-P5174	MitTx	Activator	≥98.0%	Unkown
HY-164284	LK-2	Antagonist	98.11%	Unkown
HY-P1441A	Mambalgin 1 TFA	Inhibitor	95.72%	Unkown
HY-P1411A	Psalmotoxin 1 TFA		99.37%	Unkown
HY-131261	Ibuprofen alcohol		/	Unkown
HY-155017	6-Iodoamiloride	Inhibitor	/	Unkown
HY-P5172	MitTx-alpha	Agonist	/	Unkown
HY-P5780	π-TRTX-Hm3a	Inhibitor	/	Unkown
HY-P5899	Mambalgin-3	Inhibitor	/	Unkown
HY-RS01089	ASIC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17600	Asic1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24060	Asic1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Asic1	NCBI	NCBI:41

Name
Email *

	Sorry, but the email address you supplied was invalid.