Gabra5 - gamma-aminobutyric acid (GABA) A receptor, subunit alpha 5 Gene

Mus musculus

Also known as A230018I05Rik

Gene ID: 110886 | Gene type: protein coding

About Gabra5

Summary

Predicted to enable GABA Receptor binding activity and extracellular ligand-gated ion channel activity. Predicted to contribute to GABA-A receptor activity; benzodiazepine receptor activity; and Chloride Channel activity. Involved in several processes, including inner ear development; innervation; and sensory perception of sound. Acts upstream of or within associative learning and behavioral fear response. Located in cell body and dendrite. Is expressed in brain. Human ortholog(s) of this gene implicated in bipolar disorder; developmental and epileptic encephalopathy 79; and mental depression. Orthologous to human GABRA5 (gamma-aminobutyric acid type A receptor subunit alpha5). [provided by Alliance of Genome Resources, Apr 2022]

Gabra5 Products(3)

mRNA	Protein	Name
NM_001362161.1	NP_001349090.1	gamma-aminobutyric acid receptor subunit alpha-5 precursor
NM_001362162.1	NP_001349091.1	gamma-aminobutyric acid receptor subunit alpha-5 precursor
NM_176942.4	NP_795916.1	gamma-aminobutyric acid receptor subunit alpha-5 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GABA-A receptor activity	IMP IMP: Inferred from mutant phenotype	14993607	MGI
enables GABA-gated chloride ion channel activity	IMP IMP: Inferred from mutant phenotype	14993607	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16467845	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within associative learning	IMP IMP: Inferred from mutant phenotype	12084936	MGI
acts upstream of or within behavioral fear response	IMP IMP: Inferred from mutant phenotype	12084936	MGI
involved in cochlea development	IMP IMP: Inferred from mutant phenotype	17021187	MGI
involved in inner ear receptor cell development	IMP IMP: Inferred from mutant phenotype	17021187	MGI
involved in innervation	IMP IMP: Inferred from mutant phenotype	17021187	MGI
involved in neuron development	IMP IMP: Inferred from mutant phenotype	17021187	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell body	IDA IDA: Inferred from direct assay	9682826	MGI
located in dendrite	IDA IDA: Inferred from direct assay	9682826	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

gamma-aminobutyric acid receptor subunit alpha-5

GABA(A) receptor subunit alpha-5

ligand-gated ion channel subunit

Gabra5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Gabra5	Q8BHJ7	Rdx	Rattus norvegicus	Q5WQV5	Pull Down	16467845
Cross	Gabra5	Q8BHJ7	Rdx	Rattus norvegicus	Q5WQV5	Y2H	16467845

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05213	GABRA5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21856	Gabra5 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gabra5	NCBI	NCBI:2558

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