OLFM1 - olfactomedin 1 Gene

Homo sapiens

Also known as AMY; NOE1; OlfA; NOELIN1

Gene ID: 10439 | Gene type: protein coding

About OLFM1

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:135,075,505-135,121,184 (from NCBI)

This gene has 12 transcripts (splice variants), 270 orthologues and 9 paralogues. Biased expression in brain (RPKM 118.4), adrenal (RPKM 7.6) and 1 other tissue.

Summary

This gene product shares extensive sequence similarity with the rat neuronal olfactomedin-related ER localized protein. While the exact function of the encoded protein is not known, its abundant expression in brain suggests that it may have an essential role in nerve tissue. Several alternatively spliced transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

OLFM1 Products(4)

mRNA	Protein	Name
NM_001282611.2	NP_001269540.1	noelin isoform 4 precursor
NM_001282612.1	NP_001269541.1	noelin isoform 5
NM_006334.4	NP_006325.1	noelin isoform 2 precursor
NM_014279.5	NP_055094.1	noelin isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17043677	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	16751333	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OLFM1 Protein Structure

Noelin-1

OLF

0
100
200
300
400
485 a.a.

Protein Preferred Names

Protein Names

noelin

neuroblastoma protein

OLFM1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	OLFM1	Q99784	DISC1	Homo sapiens	Q9NRI5-1	Y2H	17043677

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Sarcosinemia

Sarcosine Dehydrogenase Complex Deficiency	Sard Deficiency
Sardh Deficiency	SARCOS
Hypersarcosinemia	Sardhd
Demethylation Defect Of N-Methylglycine

Neuroblastoma

Nb	Neuroblastoma, Susceptibility To
Neuroblastomas	Central Neuroblastoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09770	OLFM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21677	Olfm1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	OLFM1	VGNC	VGNC:75416
Felis catus	OLFM1	VGNC	VGNC:63958
Rattus norvegicus	OLFM1	RGD	RGD:620320
Canis familiaris	OLFM1	VGNC	VGNC:55713
Bos taurus	OLFM1	VGNC	VGNC:32417
Mus musculus	OLFM1	MGD	MGI:1860437

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