2. NF-κB Protein Tyrosine Kinase/RTK JAK/STAT Signaling Epigenetics Stem Cell/Wnt
  3. IKK JAK STAT NF-κB
  4. EC-70124

EC-70124 is an orally active multikinase inhibitor targeting IKKβ and JAK2. EC-70124 blocks IkB phosphorylation and STAT3 (Tyr705) activation, suppressing NF-κB nuclear translocation and STAT3 transcriptional activity. EC-70124 reduces tumor growth and cancer stem cell (CSC) populations in prostate cancer cells and xenograft models. EC-70124 is promising for research of prostate cancer.

For research use only. We do not sell to patients.

EC-70124

EC-70124 Chemical Structure

CAS No. : 1185908-92-2

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EC-70124 Related Antibodies

Top Publications Citing Use of Products

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View All Isoforms
IKK-α IKK-β IKK IKKε TBK1

View All JAK Isoform Specific Products:

View All Isoforms
JAK1 JAK2 JAK3 Tyk2 JAK

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View All Isoforms
STAT3 STAT5 STAT6 STAT1

View All NF-κB Isoform Specific Products:

View All Isoforms
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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Description

EC-70124 is an orally active multikinase inhibitor targeting IKKβ and JAK2. EC-70124 blocks IkB phosphorylation and STAT3 (Tyr705) activation, suppressing NF-κB nuclear translocation and STAT3 transcriptional activity. EC-70124 reduces tumor growth and cancer stem cell (CSC) populations in prostate cancer cells and xenograft models. EC-70124 is promising for research of prostate cancer[1].

IC50 & Target

JAK2

 

NF-κB

 

IKKβ

 

STAT3

 

Molecular Weight

453.45

Formula

C26H19N3O5
CAS No.
SMILES

C[C@]12N3C4=C(C5=CC=CC=C53)C(C(NC6=O)=O)=C6C7=C4N([C@](C[C@@H]([C@H]2O)O)([H])O1)C8=CC=CC=C78
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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EC-70124 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EC-701241185908-92-2EC70124EC 70124IKKJAKSTATNF-κBIκB kinaseI kappa B kinase Janus kinaseNuclear factor-κBNuclear factor-kappaBIKKβJAK2STAT3prostate cancerInhibitorinhibitorinhibit

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