2. Disease Areas
  3. Cancer
  4. Melanoma
  5. Metastatic Melanoma

Metastatic Melanoma

Metastatic melanoma is a progressive form of skin cancer where malignant cells detach from the primary tumor, disseminate via blood or lymphatic systems, and establish secondary tumors at distant sites. Although the initial detachment of tumor cells from the primary lesion is highly efficient, the subsequent establishment of viable metastases is extremely rare, with only approximately one in 108 disseminated cells successfully seeding and forming new tumors, highlighting the inefficiency of metastasis initiation despite widespread cell dissemination.

Metastatic Melanoma (1):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-179271
    CA/HDAC-IN-1
    CA/HDAC-IN-1 (Compound 11) is a CA and HDAC inhibitor with Ki values of 7.4 nM, 31.0 nM, and 7.3 nM for hCA II, hCA IX, and hCA XII, respectively, and IC50 values of 0.21 μM and 3.60 μM for HDAC3 and HDAC8, respectively. CA/HDAC-IN-1 has anti-cancer activity against colon cancer, breast cancer, and melanoma.
    CA/HDAC-IN-1