2. Metabolic Enzyme/Protease Epigenetics Cell Cycle/DNA Damage
  3. Tyrosinase Sirtuin
  4. Decapeptide-12

Decapeptide-12, a small oligopeptide, is a tyrosinase inhibitor that interacts with C-terminal residue of tyrosinase (Kd: 61.1 μM). Decapeptide-12 is a competitive inhibitor of mushroom tyrosinase (IC50: 40 μM). Decapeptide-12 also increases transcription of SIRT. Decapeptide-12 reduces melanin content in melanocytes. Decapeptide-12 is used for the research of melanogenesis, senescence, inflammation .

For research use only. We do not sell to patients.

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Decapeptide-12 Chemical Structure

Decapeptide-12 Chemical Structure

CAS No. : 137665-91-9

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Based on 1 publication(s) in Google Scholar

Decapeptide-12 Related Antibodies

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Sirtuin SIRT1 SIRT2 SIRT3 SIRT6 SIRT5 SIRT7

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Description

Decapeptide-12, a small oligopeptide, is a tyrosinase inhibitor that interacts with C-terminal residue of tyrosinase (Kd: 61.1 μM). Decapeptide-12 is a competitive inhibitor of mushroom tyrosinase (IC50: 40 μM). Decapeptide-12 also increases transcription of SIRT. Decapeptide-12 reduces melanin content in melanocytes. Decapeptide-12 is used for the research of melanogenesis, senescence, inflammation [1][2][3].

IC50 & Target

IC50: 40 µM (Tyrosinase)[1], Kd: 61.1 μM (Tyrosinase)[2].
In Vitro

Decapeptide-12 (P4, 0.01-10 mΜ) dose-dependently inhibits mushroom tyrosinase with an IC50 value of 40 μM, and inhibits human tyrosinase by 25-35% at 100 μM[1].
Decapeptide-12 (100 μM, 7 days) leads to 43% reduction in melanin content in melanocytes with no effect on cell proliferation[1].
Decapeptide-12 (peptide P4, 0-400 μM) inhibits the monophenolase reaction with an IC50 value of 123 μM[2].
Decapeptide-12 interact with tyrosinase with a Kd value of 61.1 μM[2].
Decapeptide-12 (100 μM, 72 h) increases transcription of SIRT1, SIRT3, SIRT6, and SIRT7 with reduced cytotoxicity in human neonatal keratinocyte progenitors[3].
Decapeptide-12 (0-1 mM, 72 h) reduces Phytohemagglutinin (PHA)-stimulated PBMC cells proliferation[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Decapeptide-12 Related Antibodies

Cell Proliferation Assay[3]

Cell Line: Phytohemagglutinin (PHA)-stimulated PBMC cells
Concentration: 0, 0.025, 0.05, 0.1, 0.3, 1 mM
Incubation Time: 72 h
Result: Reduced cell proliferation by 28% at 0.05 mM and 54% at 0.1 mM.

RT-PCR[3]

Cell Line: Human neonatal keratinocyte progenitors
Concentration: 3, 10, 30, 50, 100, 300, 500, 1000 μM
Incubation Time: 72 h
Result: Increased transcription of SIRT1 by 141% relative to untreated cells, increased SIRT3, SIRT6 and SIRT7 by 121%, 147% and 95%, respectively.
Molecular Weight

1395.52

Formula

KS3WY3
CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

YRSRKYSSWY
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (71.66 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7166 mL 3.5829 mL 7.1658 mL
5 mM 0.1433 mL 0.7166 mL 1.4332 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.7166 mL 3.5829 mL 7.1658 mL 17.9145 mL
5 mM 0.1433 mL 0.7166 mL 1.4332 mL 3.5829 mL
10 mM 0.0717 mL 0.3583 mL 0.7166 mL 1.7914 mL
15 mM 0.0478 mL 0.2389 mL 0.4777 mL 1.1943 mL
20 mM 0.0358 mL 0.1791 mL 0.3583 mL 0.8957 mL
25 mM 0.0287 mL 0.1433 mL 0.2866 mL 0.7166 mL
30 mM 0.0239 mL 0.1194 mL 0.2389 mL 0.5971 mL
40 mM 0.0179 mL 0.0896 mL 0.1791 mL 0.4479 mL
50 mM 0.0143 mL 0.0717 mL 0.1433 mL 0.3583 mL
60 mM 0.0119 mL 0.0597 mL 0.1194 mL 0.2986 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Decapeptide-12 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Decapeptide-12137665-91-9Decapeptide12Decapeptide 12TyrosinaseSirtuinMelanocytesmelaninmelanogenesismushroom tyrosinasemonophenolaseoligopeptideanti-senescenceanti-aginganti-inflammationInhibitorinhibitorinhibit

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