2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease PI3K/Akt/mTOR MAPK/ERK Pathway
  3. HSP Akt CDK Raf
  4. DDO-6600

DDO-6600 is a covalent Hsp90 inhibitor. DDO-6600 disrupts the interaction between Hsp90 and its co-chaperone protein Cdc37, thereby inducing the degradation of kinase client proteins (such as AKT, CDK4, c-Raf). DDO-6600 has inhibitory activity against various cancer cells. DDO-6600 inhibits the migration and invasion of HCT-116 cells, and induces cell cycle arrest and apoptosis. DDO-6600 significantly inhibits tumor growth in the HCT-116 xenograft tumor model. DDO-6600 can be used for research on colorectal cancer.

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DDO-6600

DDO-6600 Chemical Structure

CAS No. : 2640292-37-9

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DDO-6600 Related Antibodies

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Akt Akt1 Akt2 Akt3

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

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B-Raf C-Raf Raf

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Description

DDO-6600 is a covalent Hsp90 inhibitor. DDO-6600 disrupts the interaction between Hsp90 and its co-chaperone protein Cdc37, thereby inducing the degradation of kinase client proteins (such as AKT, CDK4, c-Raf). DDO-6600 has inhibitory activity against various cancer cells. DDO-6600 inhibits the migration and invasion of HCT-116 cells, and induces cell cycle arrest and apoptosis. DDO-6600 significantly inhibits tumor growth in the HCT-116 xenograft tumor model. DDO-6600 can be used for research on colorectal cancer[1].

IC50 & Target[1]

HSP90

 

Akt

 

CDK4

 

C-Raf

 

Molecular Weight

428.53

Formula

C26H28N4O2
CAS No.
SMILES

O=C(N1C(CCCC1)C(N)=O)/C=C/C2=CN(C3=CC=CC=C3)N=C2C4=CC(C)=C(C=C4)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DDO-6600 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DDO-66002640292-37-9DDO6600DDO 6600HSPAktCDKRafHeat shock proteinsPKBProtein kinase BCyclin dependent kinaseRaf kinasesHsp90covalent inhibitorCys598Cdc37client protein degradationantitumor activityheat shock responseInhibitorinhibitorinhibit

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