Cathelicidin-PY 

Cathelicidin-PY is an antimicrobial peptide exhibiting strong antimicrobial property. Cathelicidin-PY inhibits the activation of TLR4 inflammatory response pathways induced by lipopolysaccharide (LPS) (HY-D1056). Cathelicidin-PY possesses strong antimicrobial and anti-inflammatory activities and low cytotoxic ability against RAW 264.7 cells. Cathelicidin-PY can be used for antimicrobial and anti-inflammatory research^[1].

Cathelicidin-PY exerts strong antimicrobial abilities against most of the tested microorganisms with MIC ranging from 4.69-37.5 μg/mL, and shows same antimicrobial activity against both clinically isolated drug-resistant and standard strains^[1].
Cathelicidin-PY (2.5-20 μg/mL, 24 h) exerts anti-inflammatory activitiy by inhibiting the production of nitric oxide (NO) and inflammatory cytokines such as TNF-α, IL-6, and monocyte chemoattractant protein-1 (MCP-1)^[1].
Cathelicidin-PY (5-20 μg/mL, 1 h) inhibits the LPS-induced TLR4 signaling pathway in RAW 264.7 murine macrophage cells by downregulating TLR4 expression, inhibiting JNK activation, and preventing NF-κB p65 nuclear translocation in a dose-dependent manner^[1].
Cathelicidin-PY (1xMIC, 30 min) induces perturbation of the E. coli cell membrane, as evidenced by membrane breaks, outflow of cellular inclusions, and a vague cell boundary^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

3425.13

C₁₅₁H₂₆₃N₄₇O₃₉S₂

1431866-92-0

Arg-Lys-Cys-Asn-Phe-Leu-Cys-Lys-Leu-Lys-Glu-Lys-Leu-Arg-Thr-Val-Ile-Thr-Ser-His-Ile-Asp-Lys-Val-Leu-Arg-Pro-Gln-Gly

RKCNFLCKLKEKLRTVITSHIDKVLRPQG

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. 1. Wei L, et al. Structure and function of a potent lipopolysaccharide-binding antimicrobial and anti-inflammatory peptide. J Med Chem. 2013 May 9;56(9):3546-56.