2. Cell Cycle/DNA Damage Cytoskeleton
  3. Kinesin
  4. ATX020

ATX020 is a potent, selective and orally active kinesin KIF18A inhibitor. ATX020 inhibits the ATPase activity of KIF18A in humans, rats and dogs, with IC50 values of 0.11 μM, 0.16 μM and 0.24 μM, respectively. ATX020 shows high selectivity for other motor proteins (CENP-E, Eg5, KIF15, etc.), with IC50 values >10 μM and only has a weak inhibitory effect on KIF19 (IC50 = 6.1 μM). ATX020 can inhibit cancer cells proliferation.

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ATX020

ATX020 Chemical Structure

CAS No. : 3030452-08-2

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ATX020 Related Antibodies

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Description

ATX020 is a potent, selective and orally active kinesin KIF18A inhibitor. ATX020 inhibits the ATPase activity of KIF18A in humans, rats and dogs, with IC50 values of 0.11 μM, 0.16 μM and 0.24 μM, respectively. ATX020 shows high selectivity for other motor proteins (CENP-E, Eg5, KIF15, etc.), with IC50 values >10 μM and only has a weak inhibitory effect on KIF19 (IC50 = 6.1 μM). ATX020 can inhibit cancer cells proliferation[1].

In Vitro

ATX020 (7 days) potently inhibits chromosomal instability-positive (CIN+) cancer cells (OVCAR-3, OVCAR-8, AU565) with IC50 values of 0.090 μM, 0.53 μM, and 0.21 μM, respectively and has low inhibitory activity against CIN- cancer cells (OVK18, A2780, CAL51) with IC50[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ATX020 Related Antibodies
In Vivo

ATX020 (30-100 mg/kg, p.o., once daily for 28 days) inhibits tumor growth in female Balb/C nude mice bearing OVCAR-3/OVK18 CDX tumors[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Balb/C nude mice bearing OVCAR-3 CDX tumors[1]
Dosage: 30 and 100 mg/kg
Administration: Orally administration, once daily for 28 days
Result: Ahieves 94% and 104% tumor growth inhibition of OVCAR-3.
Molecular Weight

581.75

Formula

C26H37F2N5O4SSi
CAS No.
SMILES

O=C(NC1=NC(C2CCC(F)(F)CC2)=NC(C)=C1)C3=CC=C(NS(=O)(CCO)=O)C=C3N4CC[Si](C)(C)CC4
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ATX020 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ATX0203030452-08-2ATX 020ATX-020KinesinOVCAR-3OVCAR-8AU565OVK18A2780CAL51chromosomal instabilityCINInhibitorinhibitorinhibit

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