2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies Recombinant Antibodies
  5. RbBP5 Antibody (YA102)

RbBP5 Antibody (YA102) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RbBP5.

For research use only. We do not sell to patients.

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50 μL In-stock
100 μL In-stock
250 μL   Get quote  
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Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

RbBP5 Antibody (YA102) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RbBP5.
Background

RbBP5 plays a crucial role in embryonic stem (ES) cells, particularly in neural lineage differentiation potential, by regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including those mediated by retinoic acid (By similarity). It does not affect ES cell self-renewal (By similarity). As a component or associated component of certain histone methyltransferase complexes, RbBP5 regulates transcription through recruitment of these complexes to gene promoters. As part of the MLL1/MLL complex, it is involved in mono-, di-, and trimethylation at 'Lys-4' of histone H3, which represents a specific tag for epigenetic transcriptional activation. In association with ASH2L and WDR5, RbBP5 stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A, and SETD1B.
Tag

Free
Gene ID
SwissProt ID
Molecular Weight

Predicted band size: 59 kDa; Observed band size: 59 kDa
Purity

Protein A affinity purified.
Subcellular Location

Nucleus.
Conjugation

Non-conjugated
Modification

Unmodified
RRID
Research Field

Epigenetics and Nuclear Signaling
Product Categories

Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality

Recombinant, Monoclonal
Host

Rabbit
Reactivity

Human, Mouse, Rat
Dilution Ratio

WB: 1:1000

  • Western blot analysis of extracts from HEK293(lane 2(20μg), NIH3T3 (lane 3(20μg) and C2C12(lane 4(20μg) using RbBP5 (HY-P80302) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Application

WB
Appearance

Liquid
Formulation

Supplied in 1*PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG
Sensitivity

Endogenous
Immunogen

Synthetic peptide corresponding to Human RbBP5.AA range:431-480.
Database

Entrez Gene: 5929 Human ; 213464 Mouse ; 304794 Rat

SwissProt: Q15291 Human ; Q8BX09 Mouse ;

OMIM: 600697 Human

Documentation
SDS (251 KB)

COA (191 KB)

User Guide for Antibodies (1077 KB)

RbBP5 Antibody (YA102) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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RbBP5 Antibody (YA102)
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HY-P80302
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