Anti-Mouse TCRβ Antibody (HB218)

Cat. No.: HY-P990159: Data Sheet
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Anti-Mouse TCRβ Antibody (HB218) is an anti-mouse TCRβ IgG2b monoclonal antibody. Anti-Mouse TCRβ Antibody (HB218) can deplete TCRβ⁺ T cells. Anti-Mouse TCRβ Antibody (HB218) can be used for research on inflammation conditions and cancer such as spontaneous dermatitis and squamous cell carcinoma (SCC).

For research use only. We do not sell to patients.

Anti-Mouse TCRβ Antibody (HB218) Chemical Structure

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Biological Activity
Purity & Documentation
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Description

Isotype

Armenian hamster IgG

Recommend Isotype Controls

Polyclonal Armenian hamster IgG, Isotype Control

Species Reactivity

Mouse

In Vivo

Anti-Mouse TCRβ Antibody (HB218) (100 µg, i.p., once daily for 4 days, then once every 4 days for 1 month) significantly delays the occurrence of diseases combined with CD4 mAb (HY-P990792) and CD8 mAb in CD18^-/- PL/J N6 mice with a spontaneous dermatitis model^[1].
Anti-Mouse TCRβ Antibody (HB218) (250 µg, i.p., on day 0, 3 and 12 for preventive experiment, on day 9 and 16 for extinction experiment) can exhaust all T cells in HPV38E6E7-FVB mice bearing SCC tumors^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	CD18^-/- PL/J N6 mice (5 weeks)^[1]
Dosage:	100 µg, combined with CD4 mAb and CD8 mAb
Administration:	Intraperitoneal injection (i.p.), once daily for 4 days, then once every 4 days for 1 month
Result:	Significantly delayed disease occurrence to 23.9 weeks (control group 10.2 weeks). Reduced the number of TCRβ⁺ T cells.

Animal Model:	1×10⁶ HPV38 SCC cells injected HPV38E6E7-FVB mice^[2]
Dosage:	250 µg
Administration:	Intraperitoneal injection (i.p.), on day 0, 3 and 12 for preventive experiment, on day 9 and 16 for extinction experiment
Result:	Caused rapid tumor growth. Shortened the survival period.

Accession

P01850

Application

ELISA, FACS, Functional assay, Research in vivo

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Molecular Weight

150 kDa

SMILES

[Anti-Mouse TCRβ Antibody (HB218)]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Inhibitory Antibodies User Guide (602 KB)

References

[1]. Barlow SC, et al. Development of dermatitis in CD18-deficient PL/J mice is not dependent on bacterial flora, and requires both CD4+ and CD8+ T lymphocytes. Int Immunol. 2004 Feb;16(2):345-51. [Content Brief]

[2]. Zeng Z, et al. IFN-γ Critically Enables the Intratumoural Infiltration of CXCR3+ CD8+ T Cells to Drive Squamous Cell Carcinoma Regression. Cancers (Basel). 2021 Apr 28;13(9):2131. [Content Brief]

Anti-Mouse TCRβ Antibody (HB218) Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse TCRβ Antibody (HB218)MHCMajor Histocompatibility ComplexTCRβT cellsspontaneous dermatitisSCCInhibitorinhibitorinhibit

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