2. Immunology/Inflammation
  3. Transmembrane Glycoprotein
  4. Anti-Mouse Podoplanin/glycoprotein 38 Antibody (8.1.1)

Anti-Mouse Podoplanin/glycoprotein 38 Antibody (8.1.1) 

Cat. No.: HY-P990168
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Anti-Mouse Podoplanin/glycoprotein 38 Antibody (8.1.1) is a Syrian hamster-derived IgG type antibody inhibitor, targeting to mouse Podoplanin/glycoprotein 38. Anti-Mouse Podoplanin/glycoprotein 38 Antibody (8.1.1) blocks podoplanin binding to C-type lectin receptor CLEC-2. Anti-Mouse Podoplanin/glycoprotein 38 Antibody (8.1.1) can be used for the research of cancer and inflammation, such as lung inflammation.

For research use only. We do not sell to patients.

Anti-Mouse Podoplanin/glycoprotein 38 Antibody (8.1.1)

Anti-Mouse Podoplanin/glycoprotein 38 Antibody (8.1.1) Chemical Structure

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Anti-Mouse Podoplanin/glycoprotein 38 Antibody (8.1.1) Related Antibodies

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Description

Anti-Mouse Podoplanin/glycoprotein 38 Antibody (8.1.1) is a Syrian hamster-derived IgG type antibody inhibitor, targeting to mouse Podoplanin/glycoprotein 38. Anti-Mouse Podoplanin/glycoprotein 38 Antibody (8.1.1) blocks podoplanin binding to C-type lectin receptor CLEC-2. Anti-Mouse Podoplanin/glycoprotein 38 Antibody (8.1.1) can be used for the research of cancer and inflammation, such as lung inflammation[1][2].

Isotype

Syrian hamster IgG
Species Reactivity

Mouse
IC50 & Target

Podoplanin/glycoprotein 38
In Vitro

Anti-Mouse Podoplanin/glycoprotein 38 Antibody (8.1.1) (10 μg/mL, 24 h) reducing covering area in fibroblastic reticular cells (FRCs)[1].
Anti-Mouse Podoplanin/glycoprotein 38 Antibody (8.1.1) (10 μg/mL, 24 h) reduces iNOS expression and IL-6, CXCL12 and TNF-α levels in LPS (HY-D1056)-treated alveolar macrophages[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse Podoplanin/glycoprotein 38 Antibody (8.1.1) Related Antibodies
In Vivo

Anti-Mouse Podoplanin/glycoprotein 38 Antibody (8.1.1) (100 μg, i.v., a single dose) reduces fibroblastic reticular cells (FRCs) contraction in mice[1].
Anti-Mouse Podoplanin/glycoprotein 38 Antibody (8.1.1) (100 μg/mouse, i.v., 6 h afte LPS) reduces neutrophil infiltration and ameliorates lung function decline in LPS (HY-D1056)-induced lung inflammation mice models[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wild type mice or Ccl19-Cre+Rosa26-eYFPfl/fl mice[1]
Dosage: 100 μg
Administration: Intravenously injection
Result: Showed no bleeding and inflammation, or major disorganization of lymphocytes.
Enlarged skin-draining LNs and reduced stiff.
Increased total FRC numbers and f BrdU+ FRCs numbers.
Expanded FRC network.
Increased OT-I T cell numbers 96 h after immunization with LPS (HY-D1056) and OVA and reduced T cells.
Animal Model: LPS (HY-D1056)-induced lung inflammation mice models[2]
Dosage: 100 μg/mouse
Administration: Intravenously injection, 6 h afte LPS
Result: Reduced arterial O2 saturation decline.
Showed increased activity and weight gain.
Reduced neutrophil infiltration and numbers.
Reduced total BAL protein and IL-6 levels.
Gene ID

14726  [NCBI]

Accession
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

SMILES

[Anti-Mouse Podoplanin/glycoprotein 38 Antibody (8.1.1)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-Mouse Podoplanin/glycoprotein 38 Antibody (8.1.1) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse Podoplanin/glycoprotein 38 Antibody (8.1.1)Transmembrane GlycoproteinPodoplaninGlycoprotein 38CLEC-2,Lung inflammationIl-6LPSFRCsInhibitorinhibitorinhibit

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Anti-Mouse Podoplanin/glycoprotein 38 Antibody (8.1.1)
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