2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. Anti-Mouse PD-1 Antibody (J43)

Anti-Mouse PD-1 Antibody (J43) 

Cat. No.: HY-P990824 Purity: 95.00%
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Anti-Mouse PD-1 Antibody (J43) is a kind of armenian hamster IgG antibody inhibitor, targeting to PD-1. Anti-Mouse PD-1 Antibody (J43) inhibits the interaction of PD-1 with PD-L1. Anti-Mouse PD-1 Antibody (J43) can be used for the researches of cancer and immunology, such as breast cancer and colon cancer.

For research use only. We do not sell to patients.

Anti-Mouse PD-1 Antibody (J43)

Anti-Mouse PD-1 Antibody (J43) Chemical Structure

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Description

Anti-Mouse PD-1 Antibody (J43) is a kind of armenian hamster IgG antibody inhibitor, targeting to PD-1. Anti-Mouse PD-1 Antibody (J43) inhibits the interaction of PD-1 with PD-L1. Anti-Mouse PD-1 Antibody (J43) can be used for the researches of cancer and immunology, such as breast cancer and colon cancer[1][2][3][4].

Isotype

Armenian Hamster IgG
Recommend Isotype Controls
Species Reactivity

Mouse
IC50 & Target

PD-1
In Vivo

Anti-Mouse PD-1 Antibody (J43) (10 μg, intratumorally injection, at day 0 and 3) inhibits tumor growth and prolongs survival in MCA 205 tumor mice models[1].
Anti-Mouse PD-1 Antibody (J43) (200 μg, i.p., at days 4, 8, 14, 18) suppresses tumor growth companied with anti-CD4 (HY-P990792) in B16F10 or Colon 26 tumor mice models[2].
Anti-Mouse PD-1 Antibody (J43) (500 μg/mouse at day 14 and 250 μg/mouse every other day from day 16 to 32, i.p.) induces fatal hypersensitivity in the inflammatory 4T1 breast cancer model[3].
Anti-Mouse PD-1 Antibody (J43) (200 μg, i.p., twice per week for 2 weeks) increases survival rate combined with R428 or SGI-7079 in ID8 tumor-bearing mice models[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MCA 205 tumor mice models[1]
Dosage: 10 μg
Administration: Intratumorally injection
Result: Inhibited tumor growth and prolonged survival.
Animal Model: B16F10 or Colon 26 tumor mice models[2]
Dosage: 200 μg
Administration: Intraperitoneal injection, at days 4, 8, 14, 18, companied with anti-CD4 (HY-P990792)
Result: Suppressed tumor growth and prolonged survival.
Increased the number of PD-1+ tumor-reactive CD8+ T cells in the circulation.
Gene ID

18566  [NCBI]

Accession
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse PD-1 Antibody (J43)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-Mouse PD-1 Antibody (J43) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse PD-1 Antibody (J43)PD-1/PD-L1PD-1/Programmed death-ligand 1PD-1PD-L1CancerB16F10MACColon 264T1Inhibitorinhibitorinhibit

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