Anti-Mouse CD132 (common γ chain) Antibody (3E12) 

Anti-Mouse CD132 (common γ chain) Antibody (3E12) is a rat-derived IgG2b type antibody inhibitor, targeting to mouse CD132. Anti-Mouse CD132 (common γ chain) Antibody (3E12) can block IL-2, IL-4 and IL-7. Anti-Mouse CD132 (common γ chain) Antibody (3E12) can inhibit T cells and B cells. Anti-Mouse CD132 (common γ chain) Antibody (3E12) can be used for the researches of cancer, immunology, inflammation and metabolic disease, such as tumor, skin transfer and diabetes^[1][2][3][4].

Rat IgG2b kappa

Rat IgG2b kappa, Isotype Control

Mouse

CD132 (common γ chain)

Anti-Mouse CD132 (common γ chain) Antibody (3E12) (25 μg/mL) inhibits 95% of T-cell proliferation stimulated by IL-2^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse CD132 (common γ chain) Antibody (3E12) (500 μg, i.p., every other day for 5-6 weeks) inhibits thymic T cell and conventional B cell development companied with 4G3 antibody in CD45^b congenic T cell-depleted bone marrow transplanted C57BL/6 mice^[1].
Anti-Mouse CD132 (common γ chain) Antibody (3E12) (1 mg, every other day) results in severe block in both B cell and thymic T cell development companied with 4G3 antibody in XSCID mice models^[1].
Anti-Mouse CD132 (common γ chain) Antibody (3E12) (10 mg/kg, i.p., at days 0, 2, 4, 6, 8, 10, 12, and 14) prevents the onset and development of type 1diabetes in cyclophosphamide (HY-17420)-induced non-obese diabetic mice^[2].
Anti-Mouse CD132 (common γ chain) Antibody (3E12) (0.5 mg, i.p., at days 2 and 4 after transfusion) prolongs graft survival companied with 4G3 and TUGm2 antibody in H-Y skin transferred mice^[3].
Anti-Mouse CD132 (common γ chain) Antibody (3E12) (300 μg/mouse, i.p., at days 6 and 7 after transplantation) abrogates the expansion advantage of OT-I tumor-infiltrating T lymphocytes companied with anti-CD122 (HY-P990808) in Ptgs1/Ptgs2^−/−BRAF^V600E melanoma mice models^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

16186  [NCBI]

Q3UPA9

ELISA, FACS, Functional assay, Research in vivo

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

150 kDa

[Anti-Mouse CD132 (common γ chain) Antibody (3E12)]

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Malek TR, et al. Monoclonal antibodies to the common gamma-chain as cytokine receptor antagonists in vivo: effect on intrathymic and intestinal intraepithelial T lymphocyte development. J Leukoc Biol. 1998 Jun;63(6):643-9.  [Content Brief]

  [2]. Li, Jingyue and Liang, et al. Monocyte-Derived Interleukin-15 Mediates the Pro-Inflammatory Phenotype of Cd226+ B Cells in Type 1 Diabetes.

  [3]. Chang S, et al. Anti-gamma chain and anti-IL-2Rbeta mAbs in combination with donor splenocyte transfusion induce H-Y skin graft acceptance in murine model. Transplant Proc. 2009 Nov;41(9):3913-5.  [Content Brief]

  [4]. Lacher SB, et al. PGE2 limits effector expansion of tumour-infiltrating stem-like CD8+ T cells. Nature. 2024 May;629(8011):417-425.  [Content Brief]