Anti-Mouse CD122/IL-2Rβ Antibody (TM-Beta 1)

Cat. No.: HY-P990808: Data Sheet
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Anti-Mouse CD122/IL-2Rβ Antibody (TM-Beta 1) is a rat-derived IgG2b κ type antibody inhibito, targeting to mouse CD122/IL-2Rβ. Anti-Mouse CD122/IL-2Rβ Antibody (TM-Beta 1) can block IL-2 and IL-15. Anti-Mouse CD122/IL-2Rβ Antibody (TM-Beta 1) can deplete natural killer (NK) cells and NKT cells. Anti-Mouse CD122/IL-2Rβ Antibody (TM-Beta 1) can be used for the researches of cancer, infection, inflammation, immunology and metabolic disease, such as melanoma, experimental autoimmune encephalomyelitis (EAE) and diabetes.

For research use only. We do not sell to patients.

Anti-Mouse CD122/IL-2Rβ Antibody (TM-Beta 1) Chemical Structure

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Anti-Mouse CD122/IL-2Rβ Antibody (TM-Beta 1) Featured Recommendations:

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

Biological Activity
Purity & Documentation
References
Customer Review

Description

Isotype

Rat IgG2b kappa

Recommend Isotype Controls

Rat IgG2b kappa, Isotype Control

Species Reactivity

Mouse

IC₅₀ & Target

CD122/IL-2Rβ

In Vivo

Anti-Mouse CD122/IL-2Rβ Antibody (TM-Beta 1) (50 μg, i.p., 1 day before induction) blocks IL-15 and aggravates EAE severity in MOG-induced experimental autoimmune encephalomyelitis (EAE) mice models^[1].
Anti-Mouse CD122/IL-2Rβ Antibody (TM-Beta 1) (200 μg, i.p., weekly from 5-15 weeks of age) decreases the frequency of mice that developed diabetes and delays the disease onset in not obese diabetic mice models^[2].
Anti-Mouse CD122/IL-2Rβ Antibody (TM-Beta 1) (500 μg, i.p., before and 4 days after infection) depletes natural killer (NK) cells and NKT cells in Neospora caninum infection mice models^[3].
Anti-Mouse CD122/IL-2Rβ Antibody (TM-Beta 1) (300 μg/mouse, i.p., at days 6 and 7 after transplantation) abrogates the expansion advantage of OT-I tumor-infiltrating T lymphocytes companied with anti-CD132 (HY-P990292) in Ptgs1/Ptgs2^−/−BRAF^V600E melanoma mice models^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	MOG-induced experimental autoimmune encephalomyelitis (EAE) mice models^[1]
Dosage:	50 μg
Administration:	Intraperitoneally injection, 1 day before induction
Result:	Showed earlier initiation of EAE symptoms with high clinical scores from day 9 until day 40. Reduced numbers of NK and CD8⁺CD122⁺ T cells.

Animal Model:	Not obese diabetic mice models^[2]
Dosage:	200 μg
Administration:	Intraperitoneally injection, weekly from 5-15 weeks of age
Result:	Reduced NK cells from the spleen, pancreas and PLN. Reduced CD8⁺ T cells in the pancreas. Reduced CD8⁺CD122⁺ T cells in the spleen. Abolished NK cell function but not T cell.

Gene ID

16185 [NCBI]

Accession

P16297

Application

ELISA, FACS, Functional assay, Research in vivo

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Molecular Weight

150 kDa

SMILES

[Anti-Mouse CD122/IL-2Rb Antibody (TM-Beta 1)]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Inhibitory Antibodies User Guide (602 KB)

References

[1]. Yu P, et al. IL-15-dependent CD8+ CD122+ T cells ameliorate experimental autoimmune encephalomyelitis by modulating IL-17 production by CD4+ T cells. Eur J Immunol. 2014 Nov;44(11):3330-41. [Content Brief]

[2]. Brauner H, et al. Depletion of IL-2 receptor β-positive cells protects from diabetes in non-obese diabetic mice. Immunol Cell Biol. 2016 Feb;94(2):177-84. [Content Brief]

[3]. Nishikawa Y, et al. Roles of CD122+ cells in resistance against Neospora caninum infection in a murine model. J Vet Med Sci. 2010 Oct;72(10):1275-82. [Content Brief]

[4]. Lacher SB, et al. PGE2 limits effector expansion of tumour-infiltrating stem-like CD8+ T cells. Nature. 2024 May;629(8011):417-425. [Content Brief]

Anti-Mouse CD122/IL-2Rβ Antibody (TM-Beta 1) Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CD122/IL-2Rβ Antibody (TM-Beta 1)Interleukin RelatedILCD122IL-2IL15Natural killer cellsNKTMelanomaExperimental autoimmune encephalomyelitisDiabetesInhibitorinhibitorinhibit

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