Anti-Mouse CD11a/LFA-1α Antibody (M17/4)

Cat. No.: HY-P990801 Purity: 95.00%: Data Sheet
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Anti-Mouse CD11a/LFA-1α Antibody (M17/4) is an anti-mouse CD11a/LFA-1α IgG2a monoclonal antibody. Anti-Mouse CD11a/LFA-1α Antibody (M17/4) can reduce the recruitment of effector memory CD8 T cells. Anti-Mouse CD11a/LFA-1α Antibody (M17/4) promotes the formation of xenograft tumors by reducing immune rejection reactions. Anti-Mouse CD11a/LFA-1α Antibody (M17/4) can be used for researches on cancer, infection conditions and immunology such as glioblastoma, parasitic and bacterial infections. The recommend isotype control of Anti-Mouse CD11a/LFA-1α Antibody (M17/4): Rat IgG2a kappa, Isotype Control (HY-P990679).

For research use only. We do not sell to patients.

Anti-Mouse CD11a/LFA-1α Antibody (M17/4) Chemical Structure

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Anti-Mouse CD11a/LFA-1α Antibody (M17/4) Featured Recommendations:

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Isotype

Rat IgG2a kappa

Recommend Isotype Controls

Rat IgG2a kappa, Isotype Control

Species Reactivity

Mouse

IC₅₀ & Target

CD11a/LFA-1α

In Vivo

Anti-Mouse CD11a/LFA-1α Antibody (M17/4) (300 μg, i.v., single dose, 3 hours before infection) significantly reduces effector memory CD8 T cells (Tem) recruitment and weakens the ability to eliminate parasites or bacteria in CB6F1 mice with a Plasmodium berghei ANKA sporozoites infection model or C57BL/6 mice with a Listeria monocytogenes strains infection model^[1].
Anti-Mouse CD11a/LFA-1α Antibody (M17/4) (20 mg/kg, i.p., on day 0, 2, 4 and 6) promotes the tumorigenicity of human glioblastoma (GBM) cells combined with CD40L mAb (HY-P990134) and CTLA4-Ig in the CD1 mice brain^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Plasmodium berghei ANKA sporozoites infected CB6F1 mice (6-12 weeks) or Listeria monocytogenes strains infected C57BL/6 mice (6-12 weeks)^[1]
Dosage:	300 μg
Administration:	Intravenous injection (i.v.), single dose, 3 hours before infection
Result:	Significantly reduced Tem recruitment. Decreased the ability to clear liver parasites. Weakened the ability of liver bacteria clearance.

Animal Model:	CD1 mice with an intracranial transplantation of GBM cells model^[2]
Dosage:	20 mg/kg
Administration:	Intraperitoneal injection (i.p.), on day 0, 2, 4 and 6
Result:	Promoted successful transplantation of human GBM cells into mouse brain and establish a patient derived xenograft (PDX) model.

Gene ID

16408 [NCBI]

Accession

P24063

Application

ELISA, FACS, Functional assay, Research in vivo

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse CD11a/LFA-1a Antibody (M17/4)]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Purity: 95.00%

Select Batch:

Data Sheet (262 KB) SDS (251 KB)

COA (233 KB)

Inhibitory Antibodies User Guide (602 KB)

References

[1]. Lefebvre MN, et al. Expeditious recruitment of circulating memory CD8 T cells to the liver facilitates control of malaria. Cell Rep. 2021 Nov 2;37(5):109956. [Content Brief]

[2]. Bhaduri A, et al. Outer Radial Glia-like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma. Cell Stem Cell. 2020 Jan 2;26(1):48-63.e6. [Content Brief]

Anti-Mouse CD11a/LFA-1α Antibody (M17/4) Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CD11a/LFA-1α Antibody (M17/4)IntegrinParasiteBacterialCD11a/LFA-1αCD8T cellsglioblastomaparasiticbacterialInhibitorinhibitorinhibit

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