2. Signaling Pathways
  3. Anti-infection
  4. Virus Protease

Virus Protease

Virus Protease

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Viral proteases are enzymes encoded by the genetic material (DNA or RNA) of viral pathogens. Viral proteases catalyze the cleavage of specific peptide bonds in viral polyprotein precursors or in cellular proteins. Viral proteases may use different catalytic mechanisms involving either serine, cysteine or aspartic acid residues to attack the scissile peptide bond. Selective recognition of these sequence patterns by a complementary substrate binding site of the enzyme ensures a high degree of specific recognition and cleavage.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the cause of the respiratory illness coronavirus disease 2019 (COVID-19). Initial spike protein priming by transmembrane protease, serine 2 (TMPRSS2) is essential for entry of SARS-CoV-2. After a SARS-CoV-2 virion attaches to a target cell, the cell's protease TMPRSS2 cuts open the spike protein of the virus, exposing a fusion peptide.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-148957
    5-Bromo-2′-deoxy-2′-fluorouridine
    		Inhibitor
    5-Bromo-2′-deoxy-2′-fluorouridine (Example 1), a 5-halo analog, is potential as an antiviral agent.
    5-Bromo-2′-deoxy-2′-fluorouridine
  • HY-N0560R
    Oroxylin A (Standard)
    		Inhibitor
    Oroxylin A (Standard) is the analytical standard of Oroxylin A. This product is intended for research and analytical applications. Oroxylin A is an active flavonoid compound with strong anti-cancer effects. Oroxylin A inhibits the IL-6/STAT3 pathway and NF-κB signaling, inhibits cell proliferation and induces apoptosis. Oroxylin A inhibits colitis-related carcinogenesis.
    Oroxylin A (Standard)
  • HY-150600
    NS2B/NS3-IN-7
    		Inhibitor
    NS2B/NS3-IN-7 (compound 26) is a highly potent Zika virus NS2B-NS3 protease inhibitor with a Ki value of 2.33 nM. NS2B/NS3-IN-7 can reduce amounts of ZIKV-infected cells.
    NS2B/NS3-IN-7
  • HY-N0469S
    L-Lysine-d3 hydrochloride
    		Inhibitor
    L-Lysine-d3 (hydrochloride) is the deuterium labeled L-Lysine. L-lysine is an essential amino acid with important roles in connective tissues and carnitine synthesis, energy production, growth in children, and maintenance of immune functions.
    L-Lysine-d<sub>3</sub> hydrochloride
  • HY-120757
    LP-130
    		Inhibitor
    LP-130 is a statin-based inhibitor that is a universal inhibitor with nanomolar inhibitory activity against all tested retroviral proteases. Crystal structure studies of its binding to different retroviral proteases have shown that it can adapt to different active site regions to achieve inhibition.
    LP-130
  • HY-155379
    β-Herpesvirus protease-IN-1
    		Inhibitor
    β-Herpesvirus protease-IN-1 (compound 19) is a β-herpesvirus protease inhibitor with IC50s of 2.5 μM and 0.33 μM for HCMVPro and HHV6Pro, respectively.
    β-Herpesvirus protease-IN-1
  • HY-B0923R
    Danthron (Standard)
    		Inhibitor
    Danthron (Standard) is the analytical standard of Danthron. This product is intended for research and analytical applications. Danthron is a natural product extracted from the traditional Chinese medicine Salvia miltiorrhiza Bunge. Danthron functions in regulating glucose and lipid metabolism by activating AMPK.
    Danthron (Standard)
  • HY-N0763R
    Angelicin (Standard)
    		Inhibitor
    Angelicin (Standard) is the analytical standard of Angelicin. This product is intended for research and analytical applications. Angelicin is a natural tricyclic aromatic hydrocarbon compound that is structurally related to psoralen and has anti-cancer, anti-inflammatory, anti-viral and other activities. Cytotoxic, IC50: 49.56 μM; inhibits MHV-68, IC50: 5.39 μg/ml (28.95 μM).
    Angelicin (Standard)
  • HY-155654
    SARS-CoV-2 Mpro-IN-10
    		Inhibitor
    SARS-CoV-2 Mpro-IN-10 (27h) is a potent Mpro inhibitor with IC50 value and EC50 values of 10.9 nM and 43.6 nM, respectively. SARS-CoV-2 Mpro-IN-10 can be used for the research of SARS-CoV-2 virus.
    SARS-CoV-2 Mpro-IN-10
  • HY-151448
    ZIKV-IN-5
    		Inhibitor
    ZIKV-IN-5 (compound 5c) is a low-cytotoxicity and acid-stable anti-ZIKV agent (EC50=0.71 μM). ZIKV-IN-5 effectively inhibits the activity of ZIKV NS5 MTase.
    ZIKV-IN-5
  • HY-151588
    Anticancer agent 90
    		Inhibitor
    Anticancer agent 90 is a benzothiazole-2-thiophene S-glycoside derivative with antitumor activity. Anticancer agent 90 has high inhibition against the two cell line from ovarian cancer (OVCAR-4), renal cancer (A498).
    Anticancer agent 90
  • HY-126715
    Pimelautide
    		Inhibitor
    Pimelautide (RP 44102), a desmuramyl peptidolipid, is an adjuvant. Pimelautide shows a LD50 of 410 mg/kg (i.v, mouse).
    Pimelautide
  • HY-151253
    CYP2C1/CYP2C19-IN-2
    		Inhibitor
    CYP2C1/CYP2C19-IN-2 (compound 21d) is a potent CYP2C9/CYP2C19 inhibitor, possessing no hepatotoxicity and ames toxicity. CYP2C1/CYP2C19-IN-2 can be used in study of anti-ZIKV.
    CYP2C1/CYP2C19-IN-2
  • HY-144647
    SP inhibitor 1
    		Inhibitor
    SP inhibitor 1 (compound 34) is a selective SARS-CoV-2 spike protein (SP) inhibitor with an IC50 of 3.26 μM, >25 μM, >25 μM for SP, Mpro and PLpro protein, respectively. SP inhibitor 1 is a vitro SARS-CoV-2 replication inhibitor at non-toxic concentrations (0.3250<5.98 μM). SP inhibitor 1 shows cellular antiviral activity.
    SP inhibitor 1
  • HY-176264
    DNDI-6510
    		Inhibitor
    DNDI-6510 (Compound (S)-x38) is a non-covalent SARS-CoV-2 MPro inhibitor with a IC50 of 0.04 μM. DNDI-6510 has a potent antiviral activity across SARS-CoV-2 and its variants as well as a weak efficacy to SARS-CoV-1. DNDI-6510 significantly improves drug exposure in metabolically humanized mice model (8HUM).
    DNDI-6510
  • HY-N0470S2
    L-Lysine-13C dihydrochloride
    		Inhibitor 99.90%
    L-Lysine-13C (dihydrochloride) is the 13C-labeled L-Lysine dihydrochloride. L-lysine dihydrochloride is an essential amino acid for humans with various benefits including treating herpes, increasing calcium absorption, reducing diabetes-related illnesses and improving gut health.
    L-Lysine-<sup>13</sup>C dihydrochloride
  • HY-152083
    DENV-IN-9
    		Inhibitor
    DENV-IN-9 (Compound 5f) is a DENV2 inhibitor with an EC50 of 0.88 μM.
    DENV-IN-9
  • HY-G0021S
    N-Desmethylclozapine-d8
    		Inhibitor
    N-Desmethylclozapine-d8 is the deuterium labeled N-Desmethylclozapine. N-Desmethylclozapine is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine is also a δ-opioid agonist.
    N-Desmethylclozapine-d<sub>8</sub>
  • HY-170598
    HP211206
    		Inhibitor
    HP211206 is a SARS-CoV-2 main protease (Mpro) PROTAC degrader. HP211206 effectively degrades SARS-CoV-2 Mpro and its drug-resistant mutants. HP211206 has an IC50 of 181.9 nM and a DC50 of 621 nM for Mpro. HP211206 has antiviral activity. (Pink: H117 (HY-170599); Black: linker (HY-B0236); Blue: E3 ligase ligand (HY-41547)).
    HP211206
  • HY-161245
    FGA146
    		Inhibitor
    FGA146 is a dual, selective inhibitor for Mpro and human Cathepsin L, with Kis of 2.19 μM, 0.96 μM and 0.87 μM, for Mal-Mpro, pET21-Mpro and Cathepsin L, respectively. FGA146 reveals an antiviral activity against SARS-CoV-2.
    FGA146
Cat. No. Product Name / Synonyms Application Reactivity