1. Signaling Pathways
  2. Anti-infection
  3. Virus Protease

Virus Protease

Viral proteases are enzymes encoded by the genetic material (DNA or RNA) of viral pathogens. Viral proteases catalyze the cleavage of specific peptide bonds in viral polyprotein precursors or in cellular proteins. Viral proteases may use different catalytic mechanisms involving either serine, cysteine or aspartic acid residues to attack the scissile peptide bond. Selective recognition of these sequence patterns by a complementary substrate binding site of the enzyme ensures a high degree of specific recognition and cleavage.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the cause of the respiratory illness coronavirus disease 2019 (COVID-19). Initial spike protein priming by transmembrane protease, serine 2 (TMPRSS2) is essential for entry of SARS-CoV-2. After a SARS-CoV-2 virion attaches to a target cell, the cell's protease TMPRSS2 cuts open the spike protein of the virus, exposing a fusion peptide.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-156008
    SARS-CoV-2-IN-58
    Inhibitor
    SARS-CoV-2-IN-58 (Compound 21H) is an antiviral agent against SARS-CoV-2 (EC50: 18 μM). SARS-CoV-2-IN-58 inhibits SARS-CoV-2 Mpro with an IC50 of 0.35 μM.
    SARS-CoV-2-IN-58
  • HY-151251
    CYP2C9/CYP2C19-IN-1
    Inhibitor
    CYP2C9/CYP2C19-IN-1 (compound 22d) is a potent CYP2C9/CYP2C19 inhibitor, possessing no hepatotoxicity and ames toxicity. CYP2C9/CYP2C19-IN-1 can be used in study of anti-ZIKV.
    CYP2C9/CYP2C19-IN-1
  • HY-151447
    ZIKV-IN-4
    Inhibitor
    ZIKV-IN-4 (compound 5b) is a low-cytotoxicity and acid-stable anti-ZIKV agent (EC50=3.49 μM). ZIKV-IN-4 effectively inhibits the activity of ZIKV NS5 MTase.
    ZIKV-IN-4
  • HY-N0470R
    L-Lysine (hydrochloride) (Standard)
    Inhibitor
    L-Lysine hydrochloride (Standard) is the analytical standard of L-Lysine hydrochloride. This product is intended for research and analytical applications. L-lysine hydrochloride is an essential amino acid for humans with various benefits including treating herpes, increasing calcium absorption, reducing diabetes-related illnesses and improving gut health.
    L-Lysine (hydrochloride) (Standard)
  • HY-169974
    SARS-CoV-2-IN-107
    Inhibitor
    SARS-CoV-2-IN-107 (Compound A7) is the inhibitor for SARS-CoV-2 3CLpro with an IC50 of 261.3 nM. SARS-CoV-2-IN-107 inhibits the SARS-CoV-2 replication with an EC50 of 11.7 μM. SARS-CoV-2-IN-107 exhibits anti-inflammatory activity with a NO inhibition rate of 68.6% in LPS (HY-D1056)-stimulated RAW264.7 macrophages.
    SARS-CoV-2-IN-107
  • HY-168047
    EBOV-IN-10
    Inhibitor
    EBOV-IN-10 is an orally active Ebola virus (EBOV) inhibitor with an EC50 value of 0.19 μM.
    EBOV-IN-10
  • HY-162022
    BTA-188
    Inhibitor
    BTA-188, a pyridazinyl oxime ether, is an orally active, potent inhibitor of rhinoviruses (HRV) and enterovirus (EV) 71 in vitro. BTA-188 inhibits HRV-2 replication with an IC50 of 0.8 nM and an IC90 of 11 nM. BTA-188 inhibits enterovirus with an IC50 of 82 and an IC90 of 109 nM. BTA-188 is a potential chemotherapeutic agent for infections caused by the viruses in the Picornaviridae.
    BTA-188
  • HY-N0184R
    Glycyrrhizic acid (Standard)
    Inhibitor
    Glycyrrhizic acid (Standard) is the analytical standard of Glycyrrhizic acid. This product is intended for research and analytical applications. Glycyrrhizic acid is a triterpenoid saponinl, acting as a direct HMGB1 antagonist, with anti-tumor, anti-diabetic activities.
    Glycyrrhizic acid (Standard)
  • HY-23120
    1-Hydroxyguanidine sulfate
    1-Hydroxyguanidine sulfate is an antitumor agent that inhibits mast cell P815, leukaemia P388, leukaemia L1210 and carcinosarcoma Walker 256 cells growth. 1-Hydroxyguanidine sulfate also has antiviral activity.
    1-Hydroxyguanidine sulfate
  • HY-159911
    SARS-CoV-2 Mpro-IN-29
    Inhibitor
    SARS-CoV-2 Mpro-IN-29 (Compound 7) is an inhibitor of the SARS-CoV-2 main protease (Mpro) with an IC50 of 310 nM and an EC50 of 0.5 μM in Vero cells. SARS-CoV-2 Mpro-IN-29 binds to the active site of Mpro, blocking the cleavage of viral polyproteins, showing significant antiviral activity and enhanced metabolic function. SARS-CoV-2 Mpro-IN-29 holds potential for research on SARS-CoV-2 antiviral agents.
    SARS-CoV-2 Mpro-IN-29
  • HY-169815
    HCV NS5B polymerase-IN-2
    Inhibitor
    HCV NS5B polymerase-IN-2 (Compound 298) is a Ns5b polymerase inhibitor. HCV NS5B polymerase-IN-2 is promising for research of hepatitis C virus (HCV) infections.
    HCV NS5B polymerase-IN-2
  • HY-N7108R
    7-Hydroxyflavone (Standard)
    Inhibitor
    7-Hydroxyflavone (Standard) is the analytical standard of 7-Hydroxyflavone. This product is intended for research and analytical applications. 7-Hydroxyflavone is a flavonoid isolated from Clerodendrum phlomidis, with anti-inflammatory activity. 7-Hydroxyflavone protects renal cells from nicotine (NIC)-associated cytotoxicity via the ERK/Nrf2/HO-1 pathway. 7-Hydroxyflavone inhibits PKM2 with an IC50 of 2.12 μM. 7-Hydroxyflavone inhibits COX-2 and 5-LOX with IC50 of 27 µg/mL and 33 µg/mL. 7-Hydroxyflavone is orally active.
    7-Hydroxyflavone (Standard)
  • HY-173285
    SARS-CoV-2 Mpro-IN-38
    Inhibitor
    SARS-CoV-2 Mpro-IN-38 (2-5a) is a SARS-CoV‑2 Mpro inhibitor, with an IC50 of 0.0435 μM.
    SARS-CoV-2 Mpro-IN-38
  • HY-B0448R
    Phenytoin (Standard)
    Inhibitor
    Phenytoin (Standard) is the analytical standard of Phenytoin. This product is intended for research and analytical applications. Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice.
    Phenytoin (Standard)
  • HY-159961
    SARS-CoV-2 Mpro-IN-34
    Inhibitor
    SARS-CoV-2 Mpro-IN-34 (Compound 26) is an inhibitor for SARS-CoV-2 Mpro with an IC50 of 6 nM. SARS-CoV-2 Mpro-IN-34 exhibits inhibitory efficacy against OC43 Mpro with an IC50 of 33 nM. SARS-CoV-2 Mpro-IN-34 exhibits antiviral activity in SARS-CoV-2 infected Vero E6 cell with an EC50 of 0.103 μM.
    SARS-CoV-2 Mpro-IN-34
  • HY-173362
    SARS-CoV-2 Mpro-IN-39
    Inhibitor
    SARS-CoV-2 Mpro-IN-39 (Compound 9d) is an inhibitor of the main protease (Mpro) of SARS-CoV-2, with an IC50 value of 5.94 µM, an EC50 value of 9.33 µM for inhibiting the replication of SARS-CoV-2 in Vero cells, and a cytotoxicity CC50 value of 289.63 µM. SARS-CoV-2 Mpro-IN-39 can be used in the research of the anti-COVID-19 field.
    SARS-CoV-2 Mpro-IN-39
  • HY-106161S1
    Rupintrivir-d7
    Inhibitor
    Rupintrivir-d7 is a deuterated labeled Rupintrivir. Rupintrivirvr (AG7088), an antiviral agent, is a potent, selective and irreversible inhibitor of human rhinovirus (HRV) 3C protease. Rupintrivirvr inhibits replication of a panel of 48 different HRV serotypes in H1-HeLA and MRC-5 cell protection assays, with a mean EC50 of 0.023 μM. Rupintrivirvr shows immune-modulatory effect.
    Rupintrivir-d<sub>7</sub>
  • HY-169012
    PSB-21110
    Inhibitor
    PSB-21110 is an irreversible SARS-CoV-2 Mpro inhibitor with EC50 value of 2.68 nM. PSB-21110 has antiviral activity.
    PSB-21110
  • HY-B1290S3
    2-Phenylethanol-13C2
    Inhibitor
    2-Phenylethanol-13C2 is 13C labeled β-Caryophyllene (HY-B1290). β-Caryophyllene is a CB2 receptor agonist.
    2-Phenylethanol-<sup>13</sup>C<sub>2</sub>
  • HY-N0731R
    Genkwanin (Standard)
    Inhibitor
    Genkwanin (Standard) is the analytical standard of Genkwanin. This product is intended for research and analytical applications. Genkwanin is a major non-glycosylated flavonoid with anti-flammatory activities.
    Genkwanin (Standard)
Cat. No. Product Name / Synonyms Application Reactivity