2. Signaling Pathways
  3. Immunology/Inflammation
  4. TREM receptor
  5. TREM receptor Agonist

TREM receptor Agonist

TREM receptor Isoform Comparison

TREM receptor Agonists (4):

Cat. No. Product Name Effect Purity
  • HY-P990043
    Iluzanebart
    		Agonist 98.63%
    Iluzanebart is a human monoclonal IgG1 antibody and is the agonist antibody for human TREM2 (hTREM2). Iluzanebart improves the survival and function of microglia by activating the TREM2 signaling pathway to compensate for the loss of CSF1R function. Iluzanebart can be used for research of adult-onset leukoencephalopathy associated with CSF1R (colony stimulating factor 1 receptor) (CSF1R-ALSP).
  • HY-P991441
    VGL101
    		Agonist
    VGL101 is a human IgG1 monoclonal antibody (mAb) targeting TREM-2. VGL101 is a pSYK agonist (EC50: 0.77 nM). VGL101 restores the survival ability of microglia and monocyte-derived macrophages under ALSP pathological conditions, inhibits apoptosis, and promotes the restoration of cell morphology to a state similar to that of normal activated CSF1R. VGL101 can be used in Leukoencephalopathies research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).
  • HY-P991442
    DNL-919
    		Agonist
    DNL-919 (TAK-920) is a human IgG1 monoclonal antibody (mAb) targeting TREM-2. DNL-919 can be used in Alzheimer's disease research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).
  • HY-P991220
    AL002
    		Agonist
    AL002 is a humanized monoclonal immunoglobulin G1 (IgG1) antibody and a TREM2 agonist antibody for use in neurological disease research.