Transmembrane Glycoprotein

Transmembrane glycoproteins are important components of cell membranes and are characterized by oligosaccharide chains covalently linked to polypeptide chains. Glycosylation sites are mainly located in their extracellular regions, achieved by N-linked glycosylation (linked to asparagine residues) or O-linked glycosylation (linked to serine or threonine residues). Sugar chains not only provide structural stability to proteins but also confer functional specificity. Many transmembrane glycoproteins are receptors, such as G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs). Most （clusters of differentiation）CD molecules are also transmembrane glycoproteins expressed on the surface of antigen-presenting cells^[1]^[2].

References:

[1]. L Franco, et al. The transmembrane glycoprotein CD38 is a catalytically active transporter responsible for generation and influx of the second messenger cyclic ADP-ribose across membranes. FASEB J. 1998 Nov;12(14):1507-20. [Content Brief]

[2]. Kumi Oshima, et al. SHPS-1, a multifunctional transmembrane glycoprotein. FEBS Lett. 2002 May 22;519(1-3):1-7. [Content Brief]

Transmembrane Glycoprotein Related Products (252):

By Effects:	Inhibitors (175) Ligands (6) Agonists (3) Antagonists (5) Activators (8) Modulators (3)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-P990275

Anti-Mouse CD326/EpCAM Antibody (G8.8)	Inhibitor
Anti-Mouse CD326/EpCAM Antibody (G8.8) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD326/EpCAM. Anti-Mouse CD326/EpCAM Antibody (G8.8) reacts with CD326 also known as EpCAM (Epithelial Cell Adhesion Molecule). Anti-Mouse CD326/EpCAM Antibody (G8.8) can be used for cancer research, such as lung carcinoma and colorectal carcinoma. Anti-Mouse CD326/EpCAM Antibody (G8.8) can be used for detections of western blot, immunohistochemistry, immunofluorescence and flow cytometry.

HY-P990293

Anti-Mouse CD122/IL-2Rβ Antibody (5H4)	Inhibitor
Anti-Mouse CD122/IL-2Rβ Antibody (5H4) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD122/IL-2Rβ. Anti-Mouse CD122/IL-2Rβ Antibody (5H4) can inhibit IL-2. Anti-Mouse CD122/IL-2Rβ Antibody (5H4) can be used for the researches of cancer and immunology, such as hepatocellular carcinoma.

HY-P990852

Anti-CEACAM7 Antibody (P3-7B)	Inhibitor
Anti-CEACAM7 Antibody (P3-7B) is a kind of mouse IgG1 κ chimeric antibody, targeting to human CEACAM7. Anti-CEACAM7 Antibody (P3-7B) reacts with human carcinoembryonic antigen-related cell adhesion molecule 7 (CEACAM7). Anti-CEACAM7 Antibody (P3-7B) can be used for detecting CEACAM7 in cancer.

HY-P991308

TRX385	Antagonist
TRX385 is a human monoclonal antibody (mAb) targeting LILRB4/ILT3/CD85k. TRX385 can be used in anticancer and antiviral research.

HY-P990746

Lancastotug	Inhibitor
Lancastotug is an anti-TIGIT human IgG1 κ monoclonal antibody. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-170955

HA-CD44 interaction inhibitor 3	Inhibitor
HA-CD44 interaction inhibitor 3 (compound 5d) is a Hyaluronic acid (HY-B0633A) (HA)-CD44 interaction inhibitor with antiproliferative activities. HA-CD44 interaction inhibitor 3 inhibits MDA-MB-231 (CD44++) cells and MCF-7 cells (CD44--) with EC₅₀s of 4.24 μM and 14.74 μM, respectively. HA-CD44 interaction inhibitor 3 shows the potential for cancer research.

HY-P991665

MEN1112	Inhibitor
MEN1112 (OBT357NF) is a selective humanized monoclonal antibody targeting the Bst1/CD157 antigen (EC₅₀=1 nM). MEN1112 exerts potent antitumor activity against acute myeloid leukemia (AML) cells. MEN1112 is promising for research of hematological malignancies such as AML.

HY-P990664

Anti-Melanotransferrin/CD228 Antibody
Anti-Melanotransferrin/CD228 Antibody (SC-005 antibody) is a humanized antibody expressed in CHO cells, targeting Melanotransferrin/CD228. Anti-Melanotransferrin/CD228 Antibody carries a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145.16 kDa. The isotype control for Anti-Melanotransferrin/CD228 Antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P991181

VTX-1218	Inhibitor
VTX-1218 is a humanized IgG1 monoclonal antibody targeting VSIG4.

HY-P990751

Nelmastobart	Inhibitor
Nelmastobart is an anti-BTN1A1 human IgG4 κ monoclonal antibody. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

HY-P991307

BND-35	Antagonist
BND-35 is a human monoclonal antibody (mAb) targeting LILRB4/ILT3/CD85k. BND-35 blocks the interaction of ILT3 with APOE and fibronectin, enhances the pro-inflammatory activity of various myeloid cells, and reverses ILT3-mediated immunosuppression of T cells by various suppressive myeloid cells. BND-35 has anti-tumor activity in the hILT3 transgenic mouse tumor model.

HY-P991306

ATG-032	Inhibitor
ATG-032 is a human monoclonal antibody (mAb) targeting LILRB2/ILT4. ATG-032 can be used in haematological malignancies research.

HY-P10184

CD36 Peptide P (93-110), Cys conjugated	Inhibitor
CD36 Peptide P (93-110), Cys conjugated is a Cys labelled CD36 Peptide, and can block binding of CD36 to immobilized thrombospondin and partially inhibited collagen-induced platelet aggregation.

HY-P990611

KRN-330
KRN-330 is a humanized antibody expressed in CHO cells, targeting GPA33. KRN-330 has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for KRN-330 can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990234

Anti-Mouse ICOSL/CD275 (LALA-PG) Antibody (HK5.3)	Inhibitor
Anti-Mouse ICOSL/CD275 (LALA-PG) Antibody (HK5.3) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse ICOSL/CD275. Anti-Mouse ICOSL/CD275 (LALA-PG) Antibody (HK5.3) is a chimeric antibody of the original HK5.3 antibody (HY-P990123). Anti-Mouse ICOSL/CD275 (LALA-PG) Antibody (HK5.3) contains the LALA-PG mutation region. Anti-Mouse ICOSL/CD275 (LALA-PG) Antibody (HK5.3) can neutralize ICOSL. Anti-Mouse ICOSL/CD275 (LALA-PG) Antibody (HK5.3) can be used for researches of inflammation and infection.

HY-P991671

Anafiltamig	Inhibitor
Anafiltamig is a trivalent monoclonal antibody inhibitor targeting CD79B, CD3E and MS4A1. Anafiltamig consists of a humanized IgG1κ anti-CD79B arm and a bispecific scFv-based arm targeting CD3E and MS4A1. Anafiltamig simultaneously bridges T and B cells, activating T cells and specifically killing B cell tumors. Anafiltamig can be used for B cell malignancies such as non-Hodgkin lymphoma research.

HY-P991458

hu3S193	Inhibitor
hu3S193 is a human IgG monoclonal antibody (mAb) targeting Lewis Y. hu3S193 has excellent immune effector function (complement-dependent cytotoxicity) (IC₅₀: 1.0 μg/ml) and antibody-dependent cellular cytotoxicity (IC₅₀: 5.0 μg/ml). hu3S193 can be used in small cell lung cancer (SCLC) research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P3967

Thymopoietin i/ii (29-41) (bovine)
Thymopoietin i/ii (29-41) (bovine) is a peptide corresponding to positions 29-41 of bovine thymopoietin II. Thymopoietin i/ii (29-41) (bovine) is a neuromuscular blocker.

HY-P991093

NGM-707	Inhibitor
NGM-707 is a humanized monoclonal antibody that blocks ILT2 and ILT4 receptors. NGM-707 has the potential for the study of advanced and metastatic solid tumors.

HY-P991378

MORAb-066	Inhibitor
MORAb-066 is a human monoclonal antibody (mAb) targeting CD142/F3/TF. MORAb-066 can be used in Breast cancer, Colorectal cancer, Non-small cell lung cancer and Pancreatic cancer research.

Name
Email *

	Sorry, but the email address you supplied was invalid.