2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Succinate Dehydrogenase

Succinate Dehydrogenase

Succinate Dehydrogenase (SDH), also known as electron transport chain complex II, is a vital enzyme involved in both the citric acid cycle and oxidative phosphorylation. It catalyzes the oxidation of succinate to fumarate, transferring electrons to ubiquinone in the electron transport chain, which is essential for ATP generation and mitochondrial function. In eukaryotes, SDH is composed of four subunits (SDHA-D), localized to the inner mitochondrial membrane, while in prokaryotes, it is found in the cytoplasmic membrane. SDH deficiency can lead to an abnormal accumulation of succinate, contributing to age-related organ degeneration in tissues expressing SUCNR1. Elevated succinate levels have been linked to skeletal diseases such as osteoporosis, rheumatoid arthritis, and osteoarthritis. This highlights the importance of SDH in maintaining cellular homeostasis and preventing metabolic disorders[1][2][3].

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-159481
    SDH-IN-17
    		Inhibitor
    SDH-IN-17 (compound C32), a hydrazide-containing flavonol derivative, is a potent succinate dehydrogenase (SDH) inhibitor with an IC50 of 8.42 μM. SDH-IN-17 can occupy the active site and form strong interactions with the key residues of SDH. SDH-IN-17 exhibits antifungal activity against Rhizoctonia solani (EC50=0.170 μg/mL). SDH-IN-17 disrupts the normal growth of hyphae by affecting the structural integrity of the cell membrane and cellular respiration. SDH-IN-17 has the potential for plant disease control research.
    SDH-IN-17
  • HY-W516735
    Sedaxane
    Sedaxane is a new broad-spectrum seed treatment fungicide. Sedaxane inhibits fungal respiration by binding to the succinate dehydrogenase complex in fungal mitochondria. Sedaxane has broad-spectrum activity against a variety of seed-borne and soil-borne fungi. Sedaxane can be used in the study of barley loose smut and barley stripe disease.
    Sedaxane
  • HY-B2011R
    Flutolanil (Standard)
    		Inhibitor
    Flutolanil (Standard) is the analytical standard of Flutolanil. This product is intended for research and analytical applications. Flutolanil is a broad-spectrum fungicide. Flutolanil inhibits mycelial oxygen consumption and succinate dehydrogenase in mitochondria Complex II. Flutolanil causes endocrine disruption and reproductive disorders in zebrafish after long-term exposure. Flutolanil can be used to control the fungal pathogens induced plant disease.
    Flutolanil (Standard)
  • HY-174831
    SDH-IN-28
    		Inhibitor
    SDH-IN-28 is a succinate dehydrogenase inhibitor with an IC50 value of 2.65 mg/L. SDH-IN-28 demonstrates broad-spectrum fungicidal efficacy, with EC50 values of 0.21 (Valsa mali), 0.95 (Botrytis cinerea), 0.64 (Rhizoctonia solani), 1.33 (Fusarium graminearum), and 0.66 mg/L (Gaeumannomyces graminis). SDH-IN-28 effectively preventes V. mali infection in apples.
    SDH-IN-28
  • HY-174456
    Succinate dehydrogenase-IN-10
    		Inhibitor
    Succinate dehydrogenase-IN-10 (Compound B5) is a RsSDH (Succinate dehydrogenase of R. solani) inhibitor with an IC50 of 0.12 μM. Succinate dehydrogenase-IN-10 exhibits antifungal activity against R. solani (EC50 of 0.002 μg/mL) and P. pachyrhizi.
    Succinate dehydrogenase-IN-10
  • HY-173021
    Succinate dehydrogenase-IN-7
    		Inhibitor
    Succinate dehydrogenase-IN-7 (Compound 2f) is a Succinate dehydrogenase inhibitor (IC50 = 2.51 μM). Succinate dehydrogenase-IN-7 has fungicidal activity.
    Succinate dehydrogenase-IN-7
  • HY-119459R
    Fluopyram (Standard)
    		Inhibitor
    Fluopyram (Standard) is the analytical standard of Fluopyram (HY-119459). This product is intended for research and analytical applications. Fluopyram is an orally active succinate dehydrogenase inhibitor, antifungal and nematicide. Fluopyram inhibits succinate dehydrogenase activity, activates CAR/PXR nuclear receptors, and increases caspase-3, TNF-α and NF-κB. Fluopyram inhibits the growth of F. virguliforme, Botrytis cinerea and Alternaria solani with EC50 values of 3.35, 5.389 and 0.244 µg/mL, respectively. Fluopyram induces liver and thyroid tumor formation. Fluopyram is nephrotoxic and embryotoxic.
    Fluopyram (Standard)
  • HY-169972
    Succinate dehydrogenase-IN-5
    		Inhibitor
    Succinate dehydrogenase-IN-5 (Compound M8) is the inhibitor for succinate dehydrogenase. Succinate dehydrogenase-IN-5 interfers with the energy metabolism and growth of fungi, inhibits Rhizoctonia solani, Sclerotinia sclerotiorum, Botrytis cinerea and Fusarium graminearum with EC50 < 0.3 μg/mL.
    Succinate dehydrogenase-IN-5
  • HY-174390
    SDH-IN-29
    		Inhibitor
    SDH-IN-29 (Compound A33) is a SDH inhibitor with an IC50 of 0.0709 μM. SDH-IN-29 has a broad spectrum of antifungal activities (EC50s of 0.356, 0.798 and 0.146 μg/mL for Fusarium graminearum, Sclerotinia sclerotiorum, and Rhizoctonia solani, respectively). SDH-IN-29 has moderate to significant protective effects against rice blast, wheat scab and cucumber powdery mildew.
    SDH-IN-29
  • HY-135549R
    Fluxapyroxad (Standard)
    		Inhibitor
    Fluxapyroxad (Standard) is the analytical standard of Fluxapyroxad. This product is intended for research and analytical applications. Fluxapyroxad is a synthetic broad-spectrum fungicide for the control of fungal diseases. It works by inhibiting succinate dehydrogenase in complex II of the mitochondrial respiratory chain, resulting in inhibition of spore germination, germ tubes and mycelia growth within the fungus target species.
    Fluxapyroxad (Standard)
  • HY-W753375R
    Fluindapyr (Standard)
    		Inhibitor
    Clenbuterol (hydrochloride) (Standard) is the analytical standard of Clenbuterol (hydrochloride). This product is intended for research and analytical applications. Clenbuterol (NAB-365) hydrochloride, a selective β2-adrenergic agonist, enhances skeletal muscle strength and hypertrophy. Clenbuterol hydrochloride induces growth factor mRNA, activates astrocytes, and protects rat brain tissue against ischemic damage.
    Fluindapyr (Standard)
Cat. No. Product Name / Synonyms Application Reactivity