2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. STK33
  5. STK33 Inhibitor

STK33 Inhibitor

STK33 Inhibitors (8):

Cat. No. Product Name Effect Purity
  • HY-13495
    ML281
    		Inhibitor 99.91%
    ML281 is a potent and selective STK33 inhibitor with IC50 of 14 nM.
  • HY-114331
    DLK-IN-1
    		Inhibitor 99.18%
    DLK-IN-1 (Compound 14) is an orally active, blood-brain barrier-penetrable and selective inhibitor of dual leucine zipper kinase (DLK, MAP3K12) with a Ki value of 3 nM. DLK-IN-1 inhibits Flt3, PAK4, STK33 and TrkA. DLK-IN-1 reduces p-c-Jun. DLK-IN-1 can be used in Alzheimer's disease research.
  • HY-162565
    CDD-2807
    		Inhibitor 99.52%
    CDD-2807 is an inhibitor for serine/threonine kinase 33 (STK33) with IC50 of 9.2 nM. CDD-2807 exhibits no significant toxicity in mice and can cross the blood-testis barrier without accumulating in the brain. CDD-2807 induces a reversible contraceptive effect and has potential for the development of the male contraceptive.
  • HY-176885
    CDD-2211
    		Inhibitor
    CDD-2211 is a STK33 inhibitor, with a Kd of 0.018 nM and an IC50 of 5 nM. CDD-2211 has relatively weak inhibitory effects on off-target kinases, with IC50 values of 115 nM for CLK1, 48 nM for CLK2, 187 nM for CLK4, and 78 nM for RET. CDD-2211 can be used for the study of contraception.
  • HY-13498
    BRD-8899
    		Inhibitor
    BRD-8899 is a STK33 inhibitor, with an IC50 of 11 nM.
  • HY-176884
    CDD-2110
    		Inhibitor
    CDD-2210 is a STK33 inhibitor, with a Kd of 0.1 nM and an IC50 of 38 nM. CDD-2210 has relatively weak inhibitory effects on off-target kinases, with IC50 values of 1209 nM for CLK1, 917 nM for CLK2, 544 nM for CLK4, and 746 nM for RET. CDD-2210 can be used for the study of contraception.
  • HY-176885A
    CDD-2212
    		Inhibitor
    CDD-2212 is a STK33 inhibitor, with a Kd of 1.9 nM and an IC50 of 999 nM. CDD-2212 has relatively weak inhibitory effects on off-target kinases, with IC50 values of 3223 nM for CLK1, 1555 nM for CLK2, 5884 nM for CLK4, and 1093 nM for RET. CDD-2212 can be used for the study of contraception.
  • HY-13497
    STK33-IN-1
    		Inhibitor
    STK33-IN-1 (compound 1) is a STK33 inhibitor, with an IC50 of 7 nM.