Quinone Reductase

Quinones, a class of organic compounds, are formally derived from aromatic compounds and are a subset of the quinoid family which also contains the quinone imines and the quinone methides. NQO1 (QR1, EC 1.6.99.2), also referred to as DT-diaphorase (formerly), nicotinamide quinone oxidoreductase 1, quinone reductase type 1, or menadione reductase, is a cytosolic flavoenzyme. Another member of the quinone oxidoreductases family is NQO2 (QR2, EC 1.10.99.2) which is also a FAD bound protein (25 kDa) and closely related to NQO1. In addition to NQO1 and NQO2 found in humans, an ancient NQO3 subfamily exists in eubacteria, NQO4 subfamily in fungi, and NQO5 subfamily in archaebacteria^[1]^[2].

References:

[1]. Rashid MH, et al. Interactions of the antioxidant enzymes NAD(P)H: Quinone oxidoreductase 1 (NQO1) and NRH: Quinone oxidoreductase 2 (NQO2) with pharmacological agents, endogenous biochemicals and environmental contaminants. Chem Biol Interact. 2021 Aug 25;345:109574.

[2]. Cuendet M, et al. Quinone reductase induction as a biomarker for cancer chemoprevention. J Nat Prod. 2006 Mar;69(3):460-3.

Quinone Reductase Related Products (44):

By Effects:	Inhibitors (20) Substrates (5) Activators (13) Modulator (1) Inducers (4)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-N14947

Pterulinic acid	Inhibitor
Pterulinic acid is a coenzyme I: Coenzyme Q oxidoreductase inhibitor. he IC₅₀ (μg/mL) L1210 and HL60 of Pterulinic acid to mammalian cell lines are 50 and 20 respectively. HeLaS3 25; BHK is 100.

HY-N7093R

Furaneol (Standard)	Activator
Furaneol (Standard) is the analytical standard of Furaneol. This product is intended for research and analytical applications. Furaneol is mainly isolated from American grape (Vitis labrusca) and its hybrid grape. Furaneol is an important aroma compound in fruits and contribute to the strawberry-like note in some wines.

HY-N14897

Pterulone	Inhibitor
Pterulone is a coenzyme I: Coenzyme Q oxidoreductase inhibitor found in fungus Pterula SP.82168.

HY-147548

Keap1-Nrf2-IN-10	Inhibitor
Keap1-Nrf2-IN-10 (compound 15) is a potent NQO1 inducer. Keap1-Nrf2-IN-10 inhibits oxidative stress by decreasing the levels of MDA, ROS, NQO1 in the liver for gamma-irradiated mice. Keap1-Nrf2-IN-10 improves the survival of gamma-irradiated mice.

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