2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. NADPH Oxidase

NADPH Oxidase

NOX

NADPH Oxidase

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NADPH-oxidase (NOX) is a highly regulated dynamic complex comprising membrane and cytosolic proteins and is the major source of nonmitochondrial cellular reactive oxygen species (ROS). The ROS generated by NADPH oxidases have crucial roles in various physiological processes, including innate immunity, modulation of redox-dependent signalling cascades, and as cofactors in the production of hormones.

NOX enzymes are a family of transmembrane proteins comprising seven members (NOX1-NOX5 and DUOX1 and DUOX2), each with a specific tissue distribution and activation mechanism. They catalyze the reduction of molecular oxygen to superoxide anion, which in turn reacts quickly to generate other ROS, such as hydrogen peroxide. Although basic NOX activity is crucial for normal physiology, overshooting activity of NOX enzymes leads to disease. NADPH oxidases are increasingly recognized as interesting drug targets.

NADPH Oxidase Isoform Specific Products:

NADPH Oxidase Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-156694
    Hydroxy-PP-Me
    		Activator 99.92%
    Hydroxy-PP-Me is a selective CBR1 inhibitor with an IC50 of 759 nM. Hydroxy-PP-Me can inhibit serum starvation-induced apoptosis. Hydroxy-PP-Me can enhance the cytotoxic effects of Daunorubicin (HY-13062A) and As2O3 on tumor cells. Hydroxy-PP-Me can be used in the research of cancer such as leukemia.
    Hydroxy-PP-Me
  • HY-129997
    Luteolinidin chloride
    		Inhibitor 99.73%
    Luteolinidin chloride is a deoxyanthocyanidin isolated from the plant Sorghum bicolor with antioxidant activity. Luteolinidin chloride is a potent CD38 inhibitor (Ki=11.4 μM) and protects the heart from ischemia/reperfusion injury by preserving endothelial nitric oxide synthase (eNOS) function and preventing endothelial dysfunction. Luteolinidin chloride is also a competitive inhibitor of tyrosinase (IC50=3.7 μM) and blocks the production of melanin.
    Luteolinidin chloride
  • HY-119576
    Phox-I2
    		Inhibitor 99.52%
    Phox-I2 is a selective inhibitor of p67phox-Rac1 interaction, binds to p67phox with high affinity with a Kd of ~150 nM. Phox-I2 is a NADPH oxidase 2 (NOX2) inhibitor and inhibits reactive oxygen species (ROS) production.
    Phox-I2
  • HY-120801A
    APX-115 free base
    		Inhibitor 99.54%
    APX-115 free base (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 free base effectively prevents kidney injury.
    APX-115 free base
  • HY-P1435
    NoxA1ds
    		Inhibitor
    NoxA1ds is a potent and highly selective NADPH oxidase 1 (NOX1) inhibitor (IC50=20 nM). NoxA1ds inhibits NOX1-derived O2- production in HT-29 human colon cancer cells. NoxA1ds attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro. NoxA1ds can be used in the study of hypertension, atherosclerosis and tumors.
    NoxA1ds
  • HY-152026
    NADPH oxidase-IN-1
    		Inhibitor 99.69%
    NADPH oxidase-IN-1 is an orally active NADPH oxidase (Nox) inhibitor, related with neuronal inflammation. NADPH oxidase-IN-1 can cross the blood-brain barrier (BBB), inhibits Nox2 and Nox4 with IC50s of 1.9 μM and 2.47 μM, respectively. NADPH oxidase-IN-1 suppresses pro-inflammatory cytokines production and LPS-mediated microglial migration, also has in vivo efficacy.
    NADPH oxidase-IN-1
  • HY-N0449
    Nordihydrocapsaicin
    		Modulator 99.82%
    Nordihydrocapsaicin, an analog of Capsaicin (HY-10448), is an orally active compound with pungent properties and anti-cancer activities, which is found in fresh and processed peppers. Nordihydrocapsaicin can cause a burning sensation when consumed.
    Nordihydrocapsaicin
  • HY-N3239
    Mulberrofuran G
    		Inhibitor 99.84%
    Mulberrofuran G is a NOX inhibitor (IC50: 6.9 μM) and tyrosinase inhibitor. Mulberrofuran G exhibits anti-inflammatory, antioxidant, antiviral, antitumor, and neuroprotective effects. Mulberrofuran G can be used in the research of tumors, nervous system diseases, and other conditions.
    Mulberrofuran G
  • HY-21509
    8-Hydroxycoumarin
    		99.63%
    8-Hydroxycoumarin is an intermediate in the microbial transformation of quinolone.
    8-Hydroxycoumarin
  • HY-153977
    GLX481304
    		Inhibitor 99.90%
    GLX481304 is a specific inhibitor of Nox-2 and -4, with IC50s of 1.25 μM. GLX481304 suppresses ROS production in isolated mouse cardiomyocytes and improves cardiomyocyte contractility. GLX481304 can be used for research of ischemic injury to the heart.
    GLX481304
  • HY-126195
    Fluoflavine
    		Inhibitor 99.41%
    Fluoflavine (ML-090) is a selective NOX1 inhibitor with an IC50 of 90 nM. Fluoflavine has >100 selectivity for NOX1 over NOX2, NOX3, NOX4 (all IC50>10 μM). ML-090 has an IC50 of 360 nM in HEK293 cells.
    Fluoflavine
  • HY-W614507
    Dihydronicotinamide riboside
    		Activator ≥98.0%
    Dihydronicotinamide riboside is a potent NAD+ concentration enhancer. Dihydronicotinamide riboside can be metabolized into NMNH by ATP-dependent kinase[1]< sup>.
    Dihydronicotinamide riboside
  • HY-P5328
    Noxa A BH3
    		99.61%
    Noxa A BH3 is a biological active peptide. (BH3 domain of Noxa protein)
    Noxa A BH3
  • HY-125938
    Cycloartenyl ferulate
    		98.98%
    Cycloartenyl ferulate (Cycloartenol ferulate) is one of the typical triterpene alcohols and possesses several biological activities including anti-oxidative activity, antiallergic activity, anti-inflammatory and anticancer activities.
    Cycloartenyl ferulate
  • HY-156425A
    NOX2-IN-2 diTFA
    		Inhibitor 98.15%
    NOX2-IN-2 diTFA (compound 33) is a potent NOX2 inhibitor targeting the p47phox-p22phox protein-protein interaction with a Ki of 0.24 μM. NOX2-IN-2 diTFA inhibits ROS production derived from NOX2 in cells.
    NOX2-IN-2 diTFA
  • HY-W549903
    p67phox-IN-1
    		Inhibitor 99.80%
    p67phox-IN-1 (Formula IIIa Compound) is an inhibitor targeting the interaction between Rac GTPase and p67phox protein.
    p67phox-IN-1
  • HY-105946
    Hidrosmin
    		Inhibitor
    Hidrosmin, a flavonoid, is derived from Diosmin (HY-N0178). hidrosmin exerts a beneficial effect against diabetic nephropathy (DN) by reducing inflammation, oxidative stress, and senescence pathways. Hidrosmin can be used for the research of venous insufficiency and diabetes mellitus.
    Hidrosmin
  • HY-111447
    VAS 3947
    		Inhibitor 99.59%
    VAS 3947, a specific NADPH oxidase (NOX) inhibitor, exerts a potent antiplatelet effect. VAS3947 induces apoptosis independently of anti-NOX activity, via UPR activation, mainly due to aggregation and misfolding of proteins.
    VAS 3947
  • HY-B0203B
    (Rac)-Nebivolol
    		Inhibitor
    (Rac)-Nebivolol ((Rac)-R 065824) is a racemic isomer of Nebivolol. Nebivolol is a selective β1-adrenergic receptor antagonist with an IC50 value of 0.8 nM. Nebivolol can prevent up-regulation of Nox2/NADPH oxidase and lipoperoxidation in the early stages of ethanol-induced cardiac toxicity. Vasodilatory activity.
    (Rac)-Nebivolol
  • HY-RS09461
    NOX4 Human Pre-designed siRNA Set A
    		Inhibitor

    NOX4 Human Pre-designed siRNA Set A contains three designed siRNAs for NOX4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    NOX4 Human Pre-designed siRNA Set A
    NOX4 Human Pre-designed siRNA Set A
Cat. No. Product Name / Synonyms Application Reactivity
NADPH Oxidase Isoform Comparison

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