NADPH Oxidase

NADPH Oxidase Related Products (51):

By Effects:	Inhibitors (38) Activators (3) Modulator (1)

Cat. No.	Product Name	Effect	Purity

HY-100965

Diphenyleneiodonium chloride	Inhibitor	99.91%
Diphenyleneiodonium chloride is a NADPH oxidase (NOX) inhibitor and also functions as a TRPA1 activator with an EC₅₀ of 1 to 3 μM. Diphenyleneiodonium chloride selectively inhibits intracellular reactive oxygen species.

HY-W010342

6-Aminonicotinamide		99.95%
6-Aminonicotinamide, a potent antimetabolite of nicotinamide, is competitive NADP⁺-dependent enzyme glucose-6-phosphate dehydrogenase (G6PD) inhibitor (K_i=0.46 μM). 6-Aminonicotinamide resultis ATP depletion and synergizes with DNA-crosslinking chemotherapy agents, such as Cisplatin (HY-17394), in killing cancer cells.

HY-N0088

Apocynin	Inhibitor	99.94%
Apocynin is a selective NADPH-oxidase inhibitor with an IC₅₀ of 10 μM. Apocynin improves acute lung inflammation in Carrageenan (HY-125474)-induced pleurisy mice model. Apocynin can also be used for cancer research. Apocynin reverses the aging process in mesenchymal stem cells to promote osteogenesis and increases bone mass.

HY-123962

G6PD activator AG1		99.54%
G6PD activator AG1 is a potent and selective glucose-6-phosphate dehydrogenase (G6PD) agonist with an EC50 of 3 μM. G6PD is an oxidoreductase that catalyzes the oxidation of glucose-6-phosphate to 6-phosphogluconolactone and the simultaneous reduction of NAD phosphate (NADP) to reduced NADP (NADPH). G6PD activator AG1 can reduce hemolysis of human erythrocytes.

HY-12804

VAS2870	Inhibitor	98.79%
VAS2870 is a NADPH oxidase (NOX) inhibitor.

HY-176757

N-Benzyl-N-demethylpronqodine A	Inhibitor
N-Benzyl-N-demethylpronqodine A (Compound 16) is an inhibitor of NAD(P)H:quinine acceptor oxidoreductase 1 (NQO1) with an IC₅₀ of 83.3 nM.

HY-W750654

Adonixanthin	Inhibitor
Adonixanthin ( (3S,3'R)-Adonixanthin), a carotenoid, is an orally active anti-oxidative and anti-carcinogenic agent. Adonixanthin shows an ability to suppress cell proliferation and migration in three types of glioblastoma cells Adonixanthin exerts cytoprotective effects against various types of damage and inhibits the increased production of ROS. Adonixanthin protects against light-induced cell damage through not only an anti-oxidative response but also through Nrf2 activation. Adonixanthin suppresses glioblastoma progression and adonixanthin improves blood-brain barrier hyper-permeability in an autologous blood ICH model. Adonixanthin can be used for the study of glioblastoma (GBM) and intracerebral hemorrhage (ICH).

HY-P5381

gp91 ds-tat	Inhibitor	98.27%
gp91 ds-tat, a biological active peptide, is a NADPH oxidase 2 (Nox2) inhibitor. gp91 ds-tat blocks NADPH oxidase-dependent superoxide production. gp91 ds-tat ameliorates high glucose-induced increase in total ROS, LPOs and iron levels. gp91 ds-tat inhibits homocysteine (Hcy)-induced activation of NLRP3 inflammasomes and restores Hcy-inhibited lysosomal TRPML1 channel activity. gp91 ds-tat improves cerebrovascular and cognitive function in APP/PS1 mice. gp91 ds-tat can be used for the study of Alzheimer’s disease (AD), glomerular inflammation and cardiovascular disease.

HY-B0807A

Prochlorperazine dimaleate	Inhibitor	≥98.0%
Prochlorperazine dimaleate is a first-generation antipsychotic. Prochlorperazine dimaleate can be used in the research of chemotherapy-induced nausea and vomiting (CINV). Prochlorperazine dimaleate also possesses anticancer activity. Prochlorperazine dimaleate exhibits IC₅₀ values of 6.4 μM, 4.5 μM and 2.3 μM for NOX1, NOX2 and NOX5, respectively.

HY-126213

1-Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium		99.0%
Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium (18:1 Lyso-PS) is a modified PS product generated following activation of the NADPH oxidase and lyso-PS signaling. Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium through the macrophage G2A functions to enhance existing receptor/ligand systems for resolution of neutrophilic inflammation.

HY-101499A

GKT136901 hydrochloride	Inhibitor	99.90%
GKT136901 hydrochloride is a potent, selective and orally active inhibitor of NADPH oxidase (NOX1/4), with K_is of 160 and 165 nM, respectively. GKT136901 hydrochloride is also a selective and direct scavenger of peroxynitrite. GKT136901 hydrochloride can be used for the research of diabetic nephropathy, stroke, and neurodegeneration. GKT136901 hydrochloride also has anti-inflammatory activity.

HY-156694

Hydroxy-PP-Me	Activator	99.92%
Hydroxy-PP-Me is a selective CBR1 inhibitor with an IC₅₀ of 759 nM. Hydroxy-PP-Me can inhibit serum starvation-induced apoptosis. Hydroxy-PP-Me can enhance the cytotoxic effects of Daunorubicin (HY-13062A) and As₂O₃ on tumor cells. Hydroxy-PP-Me can be used in the research of cancer such as leukemia.

HY-W614507

Dihydronicotinamide riboside	Activator	98.0%
Dihydronicotinamide riboside is a potent NAD⁺ concentration enhancer. Dihydronicotinamide riboside can be metabolized into NMNH by ATP-dependent kinase^{[1]< sup>.}

HY-Y1117

Melamine	Activator	99.17%
Melamine is an orally active inducer of Apoptosis. Melamine induces animal disease models. Melamine affects the activity of Sertoli cell and can be used for research on male reproductive function. Melamine also has neurotoxicity and nephrotoxicity. Melamine induces cognitive impairment and acute kidney injury models. Melamine can also be used to induce bladder cancer and urinary stone models.

HY-129997

Luteolinidin chloride	Inhibitor	99.73%
Luteolinidin chloride is a deoxyanthocyanidin isolated from the plant Sorghum bicolor with antioxidant activity. Luteolinidin chloride is a potent CD38 inhibitor (K_i=11.4 μM) and protects the heart from ischemia/reperfusion injury by preserving endothelial nitric oxide synthase (eNOS) function and preventing endothelial dysfunction. Luteolinidin chloride is also a competitive inhibitor of tyrosinase (IC₅₀=3.7 μM) and blocks the production of melanin.

HY-119576

Phox-I2	Inhibitor	99.44%
Phox-I2 is a selective inhibitor of p67^phox-Rac1 interaction, binds to p67^phox with high affinity with a K_d of ~150 nM. Phox-I2 is a NADPH oxidase 2 (NOX2) inhibitor and inhibits reactive oxygen species (ROS) production.

HY-N0449

Nordihydrocapsaicin	Modulator	99.82%
Nordihydrocapsaicin, an analog of Capsaicin (HY-10448), is an orally active compound with pungent properties and anti-cancer activities, which is found in fresh and processed peppers. Nordihydrocapsaicin can cause a burning sensation when consumed.

HY-153977

GLX481304	Inhibitor	99.90%
GLX481304 is a specific inhibitor of Nox-2 and -4, with IC₅₀s of 1.25 μM. GLX481304 suppresses ROS production in isolated mouse cardiomyocytes and improves cardiomyocyte contractility. GLX481304 can be used for research of ischemic injury to the heart.

HY-P5328

Noxa A BH3		99.61%
Noxa A BH3 is a biological active peptide. (BH3 domain of Noxa protein)

HY-21509

8-Hydroxycoumarin		99.63%
8-Hydroxycoumarin is an intermediate in the microbial transformation of quinolone.

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