2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
    Neuronal Signaling
  4. nAChR

nAChR

Nicotinic acetylcholine receptors

nAChR

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nAChRs (nicotinic acetylcholine receptors) are neuron receptor proteins that signal for muscular contraction upon a chemical stimulus. They are cholinergic receptors that form ligand-gated ion channels in the plasma membranes of certain neurons and on the presynaptic and postsynaptic sides of theneuromuscular junction. Nicotinic acetylcholine receptors are the best-studied of the ionotropic receptors. Like the other type of acetylcholine receptor-the muscarinic acetylcholine receptor (mAChR)-the nAChR is triggered by the binding of the neurotransmitter acetylcholine (ACh). Just as muscarinic receptors are named such because they are also activated by muscarine, nicotinic receptors can be opened not only by acetylcholine but also by nicotine —hence the name "nicotinic".

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-107679
    SR 16584
    		Antagonist
    SR 16584 is a selective antagonist of α3β4 nAChR with an IC50 of 10.2 μM.
    SR 16584
  • HY-118325
    Epibatidine dihydrochloride
    		Agonist
    Epibatidine dihydrochloride serves as a powerful agonist for nicotinic receptors.
    Epibatidine dihydrochloride
  • HY-107676A
    SIB-1553A free base
    		Agonist
    SIB-1553A free base is an orally bioavailable nicotinic acetylcholine receptors (nAChRs) agonist, with selectivity for β4 subunit-containing nAChRs. SIB-1553A free base is also a selective neuronal nAChR ligand. SIB-1553A free base is a cognitive enhancer, and has therapeutic potential for the symptomatic treatment of Alzheimer’s disease and other cognitive disorders.
    SIB-1553A free base
  • HY-116507
    AZD0328
    		Agonist
    AZD0328 is a selective α7 nAChR partial agonist. AZD0328 selectively enhances midbrain dopaminergic neuronal activity and enhances cortical dopamine levels in rats. AZD0328 improves cognitive performance.
    AZD0328
  • HY-B0979R
    Lobeline hydrochloride (Standard)
    		Agonist
    Lobeline (hydrochloride) (Standard) is the analytical standard of Lobeline (hydrochloride). This product is intended for research and analytical applications. Lobeline (α-Lobeline) hydrochloride is a brain-penetrant nicotinic receptor agonist. Lobeline hydrochloride increases dopamine (DA) release by inhibiting DA uptake into synaptic vesicles, and altering presynaptic DA storage. Lobeline hydrochloride is effective in smoking cessation.
    Lobeline hydrochloride (Standard)
  • HY-W062702
    BMS-933043
    		Agonist
    BMS-933043 is a potent and selective α7 nACh receptor partial agonist. BMS-933043 attenuates the cognitive impairment in mice and can be utilized in research related to cognitive dysfunction in schizophrenia.
    BMS-933043
  • HY-N3359A
    Lupanine perchlorate
    		Inhibitor
    Lupanine (D-Lupanine) perchlorate is a natural ketonic derivative of Sparteine ((+)-Sparteine (HY-W008350)) with a ganglioplegic activity. Lupanine perchlorate shows binding affinity for nicotinic receptor (nAChR.html" class="link-product" target="_blank">nAChR) with a Ki value of 500 nM.
    Lupanine perchlorate
  • HY-10814
    CP-810123
    		Agonist
    CP-810123 is a brain-permeable agonist of α7 nAChR for the research of cognitive impairment associated with psychiatric or neurological disorders such as schizophrenia and Alzheimer's disease.
    CP-810123
  • HY-10021R
    Varenicline Tartrate (Standard)
    		Agonist
    Varenicline (Tartrate) (Standard) is the analytical standard of Varenicline (Tartrate). This product is intended for research and analytical applications. Varenicline (CP 526555) is an orally active partial agonist of α4β2 nicotinic acetylcholine receptor (α4β2 nAChR, IC50 = 250 nM), which is the principal mediator of nicotine dependence. Varenicline is also a partial agonist of α6β2 nAChR and a full agonist of α6β2 nAChR. Varenicline blocks the direct agonist effects of nicotine on nAChR while stimulates nAChR in a more moderate way, being widely used as an aid of smoking cessation.
    Varenicline Tartrate (Standard)
  • HY-N0175R
    Cytisinicline (Standard)
    		Agonist
    Cytisinicline (Standard) is the analytical standard of Cytisinicline. This product is intended for research and analytical applications. Cytisinicline (Cytisine) is an alkaloid. Cytisinicline (Cytisine) is a partial agonist of α4β2 nAChRs, and partial to full agonist at β4 containing receptors and α7 receptors. Has been used medically to help with smoking cessation.
    Cytisinicline (Standard)
  • HY-136947
    RJR-2429
    		Agonist
    RJR-2429 is a nAChR agonist (EC50: 59 nM). RJR-2429 binds with high affinity to α4β2 receptor subtype (Ki = 1 nM). RJR-2429 induces ileum contraction.
    RJR-2429
  • HY-100906
    1,1-Dimethyl-4-acetylpiperazinium iodide
    		Agonist
    1,1-Dimethyl-4-acetylpiperazinium iodide is an agonist for nicotinic acetylcholine receptor (nAChR) that open ion channels and causes cell membrane depolarization.
    1,1-Dimethyl-4-acetylpiperazinium iodide
  • HY-175339
    Insecticidal agent 25
    		Inhibitor
    Insecticidal agent 25 (Compound WZ18) is an insecticide targeting the nicotinic acetylcholine receptors (nAChRs) in insect nervous systems. Insecticidal agent 25 disrupts neurotransmission by competitively binding to nAChRs, leading to insect paralysis and death.
    Insecticidal agent 25
  • HY-100145
    Prifuroline
    Prifuroline is an antiarrhythmic agent.
    Prifuroline
  • HY-13225
    Rivanicline oxalate
    		Agonist
    Rivanicline (RJR-2403) oxalate is a neuronal nicotinic receptor agonist. Rivanicline oxalate is highly selective for the rat brain cortex nAChRs (Ki = 26 nM, EC50 of 732 nM) and α4β2 subtype (Ki = 26 nM, EC50 = 16 μM). Rivanicline oxalate can significantly restore the learning impairment and cognitive dysfunction. Rivanicline oxalate can be used for the study of neurodegenerative diseases (such as schizophrenia or Alzheimer's disease).
    Rivanicline oxalate
  • HY-B0379AR
    Adiphenine hydrochloride (Standard)
    		Inhibitor
    Adiphenine (hydrochloride) (Standard) is the analytical standard of Adiphenine (hydrochloride). This product is intended for research and analytical applications. Adiphenine hydrochloride is a non-competitive inhibitor of nicotinic acetylcholine receptor (nAChR), with an IC50s of 1.9, 1.8, 3.7, and 6.3 μM for α1, α3β4, α4β2, and α4β4, respectively. Adiphenine hydrochloride has anticonvulsant effects.
    Adiphenine hydrochloride (Standard)
  • HY-12641R
    Pyrantel tartrate (Standard)
    		Agonist
    Pyrantel (tartrate) (Standard) is the analytical standard of Pyrantel (tartrate). This product is intended for research and analytical applications. Pyrantel tartrate is an orally active anthelmintic and an agonist of the nicotinic acetylcholine receptor (nAChR). Pyrantel tartrate can cause spasmodic muscle paralysis in parasites. Pyrantel tartrate can be used in the study of parasitic infections such as ascariasis, hookworm infections, intestinal worms (pinworm infections), trichinosis and trichinosis.
    Pyrantel tartrate (Standard)
  • HY-17033
    Rocuronium
    		Inhibitor
    Rocuronium (Org-9426) is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia.
    Rocuronium
  • HY-103172
    8-Aminoadenine
    		98.34%
    8-Aminoadenine is an adenine receptor ligand, with a Ki of 6.51 μM at the human binding site.
    8-Aminoadenine
  • HY-167896
    Hepzidine
    Hepzidine (compound 40) is a novel nicotinic acetylcholine receptor (nAChR) ligand. Hepzidine can bind to AChBP. Hepzidine can be used in neuro-related research.
    Hepzidine
Cat. No. Product Name / Synonyms Application Reactivity