2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. SIB 1663

SIB 1663 is a conformationally restricted analog of nicotine. SIB-1663 selectively activatedα2β4 and α4β4 human recombinant neuronal nAChRs. SIB 1663 can increase DA and NE release. SIB 1663 can be used for the research of neurological disease.

For research use only. We do not sell to patients.

SIB 1663

SIB 1663 Chemical Structure

CAS No. : 179064-11-0

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SIB 1663 Related Antibodies

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Description

SIB 1663 is a conformationally restricted analog of nicotine. SIB-1663 selectively activatedα2β4 and α4β4 human recombinant neuronal nAChRs. SIB 1663 can increase DA and NE release. SIB 1663 can be used for the research of neurological disease[1].

IC50 & Target[1]

α2β4

 

α4β4

 

In Vivo

SIB 1663 (3-30 mg/kg, s.c.) increases ipsilateral turning in rats with unilateral and increases withdrawal latencies in 6-OHDA (HY-B1081) nigrostriatal lesion rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

204.27

Formula

C12H16N2O
CAS No.
SMILES

COC1=NC=C2C(CCC3CCNC23)=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SIB 1663 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SIB 1663179064-11-0SIB1663SIB-1663nAChRNicotinic acetylcholine receptorsNicotineneurological diseasenAChRsDANEInhibitorinhibitorinhibit

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