2. Signaling Pathways
  3. Immunology/Inflammation
  4. Mucin

Mucin

Mucin is a class of high molecular weight glycoproteins that play crucial roles in protecting and lubricating mucosal surfaces. Mucin is characterized by a large number of O-glycosylated serine and threonine residues. Mucin can be classified into secreted mucins and membrane bounded mucins. For example, MUC1 is often overexpressed in many cancers and can interact with cell surface receptors and extracellular matrix components, affecting cell adhesion, migration and signal transduction. MUC2 is the main component of intestinal mucus, forming a physical barrier to protect the intestinal epithelium from pathogens and toxins. Different mucin subtypes have distinct expression patterns and functions in various tissues and organs. Mucin can also interact with microorganisms, participating in the regulation of the host-microbe interaction[1][2].

Mucin Isoform Specific Products:

Mucin Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-160062
    S2.2 aptamer sodium
    		Chemical
    S2.2 aptamer sodium is a nucleic acid aptamer targeting the mucin MUC1 and can be used for targeted imaging of MCF-7 cancer cells. S2.2 aptamer sodium was labeled with Cy5, and when fluorescent silicon nanodots (SiND) were present, the fluorescence was quenched; when MUC1 was also present, the fluorescence was restored. S2.2 aptamer sodium detects MUC1 with a linear range of 3.33-250 nM.
    S2.2 aptamer sodium
  • HY-P991608
    CTM01
    		Inhibitor
    CTM01 is a murine IgG1 (or humanized IgG4) monoclonal antibody inhibitor targeting MUC1. CTM01 has a broad spectrum anticancer activity against solid tumors of epithelial origin, such as breast, lung and ovarian cancer.
    CTM01
  • HY-P991166
    Ubletamig
    		Inhibitor
    Ubletamig is an anti-MUC16 human IgG4 κ monoclonal antibody. Recommend Isotype Controls: Human IgG4 kappa, Isotype Control (HY-P99003).
    Ubletamig
  • HY-P991318
    AR20.5
    		Inhibitor
    AR20.5 is a human monoclonal antibody (mAb) targeting MUC1. AR20.5 increases the number of activated CD8 T cells, CD3+CD4−CD8−(DN) T cells, and mature dendritic cells in pancreatic tumor-bearing mice. AR20.5 can be used in anti-pancreatic cancer immunity research.
    AR20.5
  • HY-P991319
    TAB-004
    		Inhibitor
    TAB-004 is a human monoclonal antibody (mAb) targeting MUC1. TAB-004 specifically recognizes tMUC1 in all major subtypes of breast cancer without affecting normal breast epithelial cells. TAB-004 can be used in triple-negative breast cancer (TNBC) research.
    TAB-004
Cat. No. Product Name / Synonyms Application Reactivity
Mucin Isoform Comparison

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