Anti-MUC1/CD227 Antibody (C595 (NCRC48))

Cat. No.: HY-P990831 Purity: 95.00%: Data Sheet
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Anti-MUC1/CD227 Antibody (C595 (NCRC48)) is a kind of mouse IgG3 κ chimeric antibody inhibitor, targeting to human MUC1/CD227. Anti-MUC1/CD227 Antibody (C595 (NCRC48)) reacts with human MUC1, also known as carbohydrate antigen 15-3 (CA15-3). Anti-MUC1/CD227 Antibody (C595 (NCRC48)) can be used for the researches of cancer, such as ovarian cancer.

For research use only. We do not sell to patients.

Anti-MUC1/CD227 Antibody (C595 (NCRC48)) Chemical Structure

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Anti-MUC1/CD227 Antibody (C595 (NCRC48)) Featured Recommendations:

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MUC1

Biological Activity
Purity & Documentation
References
Customer Review

Description

Isotype

Mouse IgG3 kappa

Recommend Isotype Controls

Mouse IgG3 kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

MUC1/CD227

In Vivo

Anti-MUC1/CD227 Antibody (C595 (NCRC48)) (5 or 15 mg/kg, i.p., once a week for 3 weeks) inhibits tumor growth and ascites production in OVCAR-3 EOC xenograft mice (nude athymic BALB/c)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	OVCAR-3 EOC xenograft mice models (6-8 weeks, female, nude athymic BALB/c)^[1]
Dosage:	5 or 15 mg/kg
Administration:	Intraperitoneally injection, once a week for 3 weeks
Result:	Produced less ascites. Inhibited tumor growth. Reduced CA125 levels at 15 mg/kg. Reduced targeted lesions.

Gene ID

4582 [NCBI]

Accession

P15941

Application

ELISA, FACS, Functional assay, Research in vivo

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-MUC1/CD227 Antibody (C595 (NCRC48))]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Purity: 95.00%

Select Batch:

Data Sheet (259 KB) SDS (251 KB)

COA (232 KB)

Inhibitory Antibodies User Guide (602 KB)

References

[1]. Wang L, et al. Anti-MUC1 monoclonal antibody (C595) and docetaxel markedly reduce tumor burden and ascites, and prolong survival in an in vivo ovarian cancer model. PLoS One. 2011;6(9):e24405. [Content Brief]

Anti-MUC1/CD227 Antibody (C595 (NCRC48)) Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-MUC1/CD227 Antibody (C595 (NCRC48))MucinMUC1CD227CA15-3Ovarian cancerOVCAR-3Inhibitorinhibitorinhibit

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