2. Signaling Pathways
  3. PROTAC
  4. Molecular Glues

Molecular Glues

Molecular Glues

Related Products

PDF 0.26 MB

Protein degradation agents based on the ubiquitin-proteasome pathway include a part of molecular glues. Molecular glues are a class of small molecule compounds that can induce or stabilize the interaction between proteins. If one of the protein is ubiquitin ligase, molecular glue can cause another protein to undergo ubiquitin modification and degradation through the proteasome pathway, which is similar to PROTAC. However, these molecules are classified as ligand for E3 ligase as functional molecules in subsequent classification. Older drugs, thalidomide, lenalidomide, and pomalidomide, together with CC-90009 and CC-92480 reported later all belong to this category.

Molecular Glues Related Products (194):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-169077
    IKZF3 degrader 1
    IKZF3 degrader 1 (compound 19a) is a molecular glue degrader of IKZF3 (EC50=0.012 μM). IKZF3 degrader 1 promotes the binding of IKZF3 to Cereblon (CRBN), leading to the ubiquitination and degradation of IKZF3.
    IKZF3 degrader 1
  • HY-176255
    TBK1 degrader-4
    TBK1 degrader-4 (Compound 30) is a molecular glue degrader targeting TBK1. TBK1 degrader-4 effectively inhibits cyst growth, alleviates inflammation, and reduces the levels of pro-inflammatory factors such as Ccl2, IFNβ, and IL-6. TBK1 degrader-4 is promising for research of autosomal dominant polycystic kidney disease (ADPKD).
    TBK1 degrader-4
  • HY-155552
    GSPT1 degrader-1
    GSPT1 degrader-1 (compound 9q) is a potent degrader of G1 to S phase transition 1 (GSPT1) via ubiquitin-proteasome system, serves as one of Molecular Glues. GSPT1 degrader-1 also induces cell G0/G1 phase arrest and apoptosis.
    GSPT1 degrader-1
  • HY-161883
    JP-2-249 3036530-41-0
    JP-2-249 is a molecular glue that acts as a potent degrader of SMARCA2. JP-2-249 shows decreasing protein level of SMARCA2 in MV-4-11 cells at 1-10 μM.
    JP-2-249
  • HY-156747
    GSPT1 degrader-2 2803879-60-7
    GSPT1 degrader-2 (Compound 210) is a potent and orally active GSPT1 molecular glue degrader (DC50: < 30 nM). GSPT1 degrader-2 is an antitumor agent.
    GSPT1 degrader-2
  • HY-175283
    ABT-002 2438239-83-7
    ABT-002 is a molecular glue degrader targeting GSPT1 and NEK7. ABT-002 is promising for research of hepatocellular carcinoma (HCC).
    ABT-002
  • HY-173366
    dGEM3
    dGEM3 is a molecular glue degrader targeting GEMIN3 (a member of the survival of motor neuron complex). dGEM3 can be used in the research of diseases related to abnormal protein regulation, such as cancer and neurodegenerative diseases.
    dGEM3
  • HY-176444
    CDK2 degrader 6 3036606-92-2 99.81%
    CDK2 degrader 6 (compound 6) is an orally active and potent CDK2 molecular glue degrader with a DC50 of 46.5 nM. CDK2 degrader 6 can be used in the study of breast cancer.
    CDK2 degrader 6
  • HY-175040
    PROTAC FLT3/GSPT1/IKZF1/3 degrader-1
    PROTAC FLT3/GSPT1/IKZF1/3 degrader-1 is a FLT3 PROTAC degrader (DC50 = 1.2 nM). PROTAC FLT3/GSPT1/IKZF1/3 degrader-1 functions as a molecular glue to degrade cereblon substrates GSPT1 and IKZF1/3. PROTAC FLT3/GSPT1/IKZF1/3 degrader-1 exhibits antiproliferative activity against drug-resistant acute myeloid leukemia (AML) cells and is potentially useful in AML research. (Pink: FLT3/GSPT1/IKZF1/3 ligand: (HY-169374); Blue: Thalidomide ligand: (HY-14658); Black: Kinker; Thalidomide ligand + linker: (HY-W1123823)).
    PROTAC FLT3/GSPT1/IKZF1/3 degrader-1
  • HY-162331
    STING Degrader-1
    STING Degrader-1 (compound 2), a molecular glue, is a potent STING degrader that covalently binds to STING and E3 ligase. STING Degrader-1 exhibits a "hook effect", that degrades 75% STING protein at 10 μM, and degrades ca. 30% STING protein at 30 μM.
    STING Degrader-1
  • HY-174329
    mrt-5702D
    mrt-5702D is a molecular glue degrader targeting cereblon (CRBN). mrt-5702D forms a CRBN-MRT-5702D-G3BP2 ternary complex to activate the ubiquitin-proteasome system for G3BP2 degradation. mrt-5702D is promising for research of G3BP2-related cancers (e.g., breast cancer, lung cancer) and neurodegenerative diseases.
    mrt-5702D
  • HY-170574
    CQ627
    CQ627 is a molecular glue targeting the degradation of RIOK2. It effectively induces the degradation of RIOK2 in the MOLT4 leukemia cell line via the ubiquitin-proteasome system (UPS) by recruiting the E3 ubiquitin ligase RNF126, with a DC50 value of 410 nM. CQ627 dose-dependently induces apoptosis in MOLT4 leukemia cells, blocks their cell cycle in the G2/M phase, and exhibits antiproliferative activities in various cancer cell lines. CQ627 also demonstrates in vivo anticancer activity in a MOLT4 xenograft mouse model.
    CQ627
  • HY-153805
    Z-NCTS 1373391-77-5
    Z-NCTS is an RNA mismatch binding molecule that recognizes the 5’-r(XGG)-3’/5’-r(XGG)-3’ sequence (X=U or A) and acts as a molecular glue for RNA.
    Z-NCTS
  • HY-160533
    IKZF1-degrader-2 2915330-86-6
    IKZF1-degrader-2 (Compound 3) is an IKZF1 molecular glues degrader. IKZF1-degrader-2 has anticancer activity and low toxicity.
    IKZF1-degrader-2
  • HY-161796
    UNC8732 2929304-05-0
    UNC8732 is an NSD2 inhibitor and degrader.
    UNC8732
  • HY-163810
    BRD9 Degrader-3 3033018-77-5
    BRD9 Degrader-3 (compound B20) is a BRD9 molecular glue, with a DC50 of <1.25 nM.
    BRD9 Degrader-3
  • HY-173274
    CB039 3056259-55-0
    CB039 is a selective a molecular glue degrader that targets RBM39 (RNA-binding protein 39). CB039 promotes the formation of a ternary complex between RBM39 and the E3 ubiquitin ligase CUL4-DCAF15, leading to proteasomal degradation of RBM39. CB039 is promising for research of cancers with RBM39 dependency, such as acute myeloid leukemia (AML) and ovarian cancer.
    CB039
  • HY-175334
    DHC-286 2920443-08-7
    DHC-286 is a molecular glue degrader targeting GSPT1. DHC-286 recruits GSPT1 to the CRL4CRBN ubiquitin ligase complex, promoting GSPT1 ubiquitination and proteasomal degradation, inducing cytotoxicity. DHC-286 is promising for research of cancers such as acute myeloid leukemia.
    DHC-286
  • HY-170820
    XYD049 3006788-11-7
    XYD049 (compound 7d) is a CRBN-type molecular glue targeting GSPT1 (DC50=19 nM), which can be used for the research of MYC-driven castration-resistant prostate cancer (CRPC). XYD049 can effectively inhibit the growth of 22Rv1 cells (IC50=7 nM) and has in vivo antitumor efficacy. XYD049 downregulates the CRPC-related oncogenes in 22Rv1 cells, including AR, AR-v7, PSA, and c-Myc. XYD049 is composed of a molecular glue linker (black part) NH2-C5-NH-Boc (HY-W004710), a CRBN-type E3 ligase ligand (blue part) Thalidomide 4-fluoride (HY-41547), and a target protein ligand (red part) GSPT1 ligand-1 (HY-170821), in which the E3 ligase ligand + liner form a conjugate E3 Ligase Ligand-linker Conjugate 158 (HY-170822).
    XYD049
  • HY-175437
    MRT-7612
    MRT-7612 (Compound 4) is a cereblon-based tyrosine kinases molecular glue degrader. MRT-7612 significantly induces HCK and LYN degradation, with week efficacy on LCK. MRT-7612 can be used for cancers like chronic myeloid leukemia, autoimmune and chronic inflammatory diseases research.
    MRT-7612