2. Signaling Pathways
  3. PROTAC
  4. Molecular Glues
  5. Molecular Glues Degrader

Molecular Glues Degrader

Molecular Glues Degraders (18):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-132199
    SJ6986 2765625-93-0 98.00%
    SJ6986 is a potent, selective and orally active GSPT1/2 Molecular Glue degrader, with a DC50 of 2.1 nM (Dmax 99%) for GSPT1.
    SJ6986
  • HY-157334
    DEG-77 3032265-06-5 99.03%
    DEG-77, is a IKZF2 and CK1α targeted molecular glue, with DC50s of 15.3 nM and 10 nM, respectively. DEG-77 possesses suitable pharmacokinetic properties, solubility, and selectivity for in vivo studies (t1/2=8h). DEG-77 can be used for acute myeloid leukemia (AML) study.
    DEG-77
  • HY-159099
    HbF inducer 2 2654011-51-3 99.15%
    HbF inducer 3 (Compound dWIZ-2) is an orally active molecular glue, which degrades the WIZ transcription factor (DC50=13 nM in primary human erythroid precursor cell) and induces the expression of fetal hemoglobin (HbF) (EC50=100 nM). HbF inducer 3 exhibits good pharmacokinetic characteristics in cynomolgus monkeys.
    HbF inducer 2
  • HY-156828
    MMH2 98.95%
    MMH2 is a novel BRD4 molecular glue degrader that functions by recruiting the CUL4 and DCAF16 ligases to the second bromodomain of BRD4 (BRD4BD2).
    MMH2
  • HY-156827
    MMH1 98.08%
    MMH1 is a novel BRD4 molecular glue degrader that functions by recruiting the CUL4 and DCAF16 ligases to the second bromodomain of BRD4 (BRD4BD2).
    MMH1
  • HY-160525
    NVS-VHL720 98.63%
    NVS-VHL720 is a molecular glue degrader that targets cysteine dioxygenase (CDO1).
    NVS-VHL720
  • HY-159098
    dWIZ-1
    dWIZ-1 is a potent WIZ molecular glue degrader. dWIZ-1 recruitments WIZ(ZF7) to cereblon (CRBN) induces WIZ degradation. dWIZ-1 has the potential for the research of sickle cell disease (SCD).
    dWIZ-1
  • HY-170952
    LYG-409 3053857-55-6 98.11%
    LYG-409 is an orally active degrader of GSPT1. LYG-409 shows excellent anti-acute myeloid leukemia and prostate cancer in vivo with TGI of 94.34% and 104.49%, respectively. LYG-409 inhibits KG-1 cells mediated by the degradation of GSPT1 with an IC50 of 9.50 nM, with a DC50 of 7.87 nM in vitro.
    LYG-409
  • HY-139972
    PROTAC(H-PGDS)-7 2761281-50-7 99.42%
    PROTAC(H-PGDS)-7 is a Hematopoietic prostaglandin D synthase (H-PGDS) molecular glue degrader, with a DC50 of 17.3 pM.
    PROTAC(H-PGDS)-7
  • HY-148523
    HQ005 2750644-31-4 99.51%
    HQ005 is a potent CCNK degrader with an DC50 value of 0.041 µM. HQ005 is a molecular-glue degrader that mediates interactions between target proteins and components of the ubiquitin-proteasome system to cause selective protein degradation.
    HQ005
  • HY-162533
    GSPT1 degrader-4 3034764-32-1
    GSPT1 degrader-4 (3) is a GSPT1 molecule glue (DC50 of 25.4 nM), with an IC50 of 39 nM for CAL51 proliferation.
    GSPT1 degrader-4
  • HY-170953
    QXG-6442
    QXG-6442 is a CK1α Molecular Glue Degrader. QXG-6442 exhibits CK1α degradation potency with a DC50 of 5.7 nM and a Dmax of 90%. QXG-6442 induces antiproliferative effects in MOLM-14 cell line.
    QXG-6442
  • HY-172930
    PVTX-405 2991021-08-8
    PVTX-405 is a selective and oral active IKZF2 molecular glue degrader with a DC50  of  0.7 nM and a Dmax of 91%. PVTX-405 enhances degradation efficiency, significantly reduces off-target degradation, and alleviates hERG inhibition with IC50 of 48 µM. PVTX-405 significantly inhibits the growth of MC38 tumors, with greater synergistic anti-cancer efficacy in combination with immune checkpoint therapies (ICTs) (anti-PD1 or anti-LAG3) in the MC38 mouse tumor xenograft model using Crbn391V C57BL/6 mice.
    PVTX-405
  • HY-176128
    BWA-6047
    BWA-6047 is a dual AR/AR-V7 and GSPT1 PROTAC degrader (AR: DC50 = 3.7 nM; AR-V7: DC50 = 3.0 nM; GSPT1: DC50 = 1.2 nM). BWA-6047 promotes ubiquitination and degradation of AR/AR-V7 and, through its molecular glue properties, induces the formation of a PPI between GSPT1 and CRBN, leading to GSPT1 degradation. BWA-6047 can be used in prostate cancer research (Pink: AR/AR-V7 ligand (HY-176129); Blue: E3 CRBN ligand (HY-W069604); Black: linker (HY-W069604)).
    BWA-6047
  • HY-156747
    GSPT1 degrader-2 2803879-60-7
    GSPT1 degrader-2 (Compound 210) is a potent and orally active GSPT1 molecular glue degrader (DC50: < 30 nM). GSPT1 degrader-2 is an antitumor agent.
    GSPT1 degrader-2
  • HY-163810
    BRD9 Degrader-3 3033018-77-5
    BRD9 Degrader-3 (compound B20) is a BRD9 molecular glue, with a DC50 of <1.25 nM.
    BRD9 Degrader-3
  • HY-174371
    INNO-220 3032576-92-1
    INNO-220 is an orally active, CRBN-dependent molecular glue degrader targeting CK1α. INNO-220 induces cell cycle arrest at G0/G1 phase and triggers apoptosis by degrading CK1α. INNO-220 disrupts the assembly and function of the CARD11/BCL10/MALT1 complex, thereby inhibiting NF-κB signaling in stimulated T cells and lymphoma cells that harbor an activating mutation in CARD11. INNO-220 provides a new direction for lymphoma research.
    INNO-220
  • HY-162534
    GSPT1 degrader-5 3034764-38-7
    GSPT1 degrader-5 (4) is a GSPT1 molecule glue (DC50 of 144 nM).
    GSPT1 degrader-5