2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. mAChR

mAChR

Muscarinic acetylcholine receptor

mAChR

Related Products

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mAChRs (muscarinic acetylcholine receptors) are acetylcholine receptors that form G protein-receptor complexes in the cell membranes of certainneurons and other cells. They play several roles, including acting as the main end-receptor stimulated by acetylcholine released from postganglionic fibersin the parasympathetic nervous system. mAChRs are named as such because they are more sensitive to muscarine than to nicotine. Their counterparts are nicotinic acetylcholine receptors (nAChRs), receptor ion channels that are also important in the autonomic nervous system. Many drugs and other substances (for example pilocarpineand scopolamine) manipulate these two distinct receptors by acting as selective agonists or antagonists. Acetylcholine (ACh) is a neurotransmitter found extensively in the brain and the autonomic ganglia.

mAChR Isoform Specific Products:

mAChR Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-137388A
    p-F-HHSiD hydrochloride
    		Antagonist 99.0%
    p-F-HHSiD (p-Fluorohexahydrosiladifenidol) hydrochloride is a selective M3 mAChR antagonist. p-F-HHSiD hydrochloride blocks Acetylcholine-mediated vasodilatation in human umbilical vein endothelial cells (HUVECs).
    p-F-HHSiD hydrochloride
  • HY-115871
    PDE4-IN-4
    		Antagonist
    PDE4-IN-4 is a dual M3 (pIC50 = 10.2) antagonist-PDE4 (pIC50 = 8.8) inhibitor for the inhaled research of pulmonary diseases.
    PDE4-IN-4
  • HY-17366R
    Clozapine N-oxide (Standard)
    		Agonist
    Clozapine N-oxide (Standard) is the analytical standard of Clozapine N-oxide. This product is intended for research and analytical applications. Clozapine N-oxide is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide cannot cross the blood-brain barrier[1][2][3][4]. Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC50=11 nM) agonist[5][6].
    Clozapine N-oxide (Standard)
  • HY-100152
    Beperidium iodide
    		Antagonist 99.97%
    Beperidium iodide shows a competitive antagonistic effect against acetylcholine receptor with a pA2 of 7.93.
    Beperidium iodide
  • HY-B1188A
    Propantheline
    		Antagonist
    Propantheline is an orally active mAChR antagonist. Propantheline can be used in the research of smooth muscle dysfunction, excessive sweating, cramps or spasms of the stomach, intestines or bladder, and involuntary urination.
    Propantheline
  • HY-B0954
    Oxyphencyclimine hydrochloride
    		Antagonist 99.61%
    A new tertiary amine, Oxyphencyclimine hydrochloride，has been investigated for its effects on the peripheral parasympathetic system.
    Oxyphencyclimine hydrochloride
  • HY-W654210
    Glycopyrrolate-d3 bromide
    		Antagonist ≥99.0%
    Glycopyrrolate-d3 (bromide) is deuterium labeled Glycopyrrolate. Glycopyrrolate (Glycopyrronium bromide), a quaternary ammonium derivative, is a muscarinic receptor antagonist. Glycopyrrolate has bronchoprotective effect and produces a beneficial effect on blood pressure. Glycopyrrolate can be used for the research of bronchial diseases.
    Glycopyrrolate-d<sub>3</sub> bromide
  • HY-123337
    Zamifenacin
    		Antagonist 99.81%
    Zamifenacin (UK-76654) is a potent gut-selective muscarinic M3 receptor antagonist. Zamifenacin significantly reduces colonic motility in irritable bowel syndrome.
    Zamifenacin
  • HY-101036R
    Choline bitartrate (Standard)
    Choline (bitartrate) (Standard) is the analytical standard of Choline (bitartrate). This product is intended for research and analytical applications. Choline bitartrate is a vitamin-like essential nutrient, can affect diseases such as liver disease, atherosclerosis and neurological disorders. Choline bitartrate is a precursor for the neurotransmitter acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.
    Choline bitartrate (Standard)
  • HY-142119S
    5-Hydroxy tryptophol β-D-glucuronide-d4
    		98.0%
    5-Hydroxy tryptophol β-D-glucuronide-d4 is the deuterium labeled 5-Hydroxy tryptophol β-D-glucuronide.
    5-Hydroxy tryptophol β-D-glucuronide-d<sub>4</sub>
  • HY-B0321S
    Tropicamide-d3
    		99.10%
    Tropicamide-d3 is the deuterium labeled Tropicamide. Tropicamide (Ro 1-7683) is a selective M4 muscarinic acetylcholine receptor antagonist. Tropicamide produces short acting mydriasis (dilation of the pupil) and cycloplegia when applied as eye drops.
    Tropicamide-d<sub>3</sub>
  • HY-B1188S
    Propantheline-d3 bromide
    		Inhibitor 99.00%
    Propantheline-d3 (bromide) is the deuterium labeled Propantheline bromide. Propantheline bromide is an antimuscarinic agent, used for the treatment of hyperhidrosis, cramps or spasms of the stomach, intestines or bladder, and enuresis.
    Propantheline-d<sub>3</sub> bromide
  • HY-B0461R
    Trospium chloride (Standard)
    		Antagonist
    Trospium (chloride) (Standard) is the analytical standard of Trospium (chloride). This product is intended for research and analytical applications. Trospium chloride is an orally active, specific and competitive antagonist of muscarinic cholinergic receptors (mAChRs), with antimuscarinic activity. Trospium chloride binds to muscarinic receptors M1, M2 and M3 with high affinity, but not nicotinic, cholinergic receptors.
    Trospium chloride (Standard)
  • HY-110239
    Perlapine
    		Agonist 99.6%
    Perlapine is a potent muscarinic DREADD (Designer Receptors Exclusively Activated by Designer agents) agonist Perlapine exhibits >10000-fold selectivity for hM3Dq over hM3 receptors.
    Perlapine
  • HY-P4156
    VLVNTFCDSCIPKTYWNLGY TFA
    VLVNTFCDSCIPKTYWNLGY TFA is an antigenic peptide of M3 muscarinic receptor (M3R). VLVNTFCDSCIPKTYWNLGY TFA can be used in ELISA.
    VLVNTFCDSCIPKTYWNLGY TFA
  • HY-B1230
    Camylofine
    		Inhibitor
    Camylofin is an antimuscarinic, is a smooth muscle relaxant .
    Camylofine
  • HY-U00082
    Tigloidin
    		Antagonist 99.91%
    Tigloidin is an analogue of atropine, with anticholinergic activity.
    Tigloidin
  • HY-119226
    VU0152099
    		Agonist 98.25%
    VU0152099 is a potent, selective and brain-penetrant mAChR M4 positive allosteric modulator with an EC50 of 0.4 µM for rat M4 receptor. VU0152099 is inactive for other mAChR subtypes or other GPCRs. VU0152099 has no agonist activity but potentiated responses of M4 to acetylcholine.
    VU0152099
  • HY-122520
    Fentonium bromide
    		Inhibitor 98.75%
    Fentonium bromide is an anti-ulcerogenic, anticholinergic and antispasmodic agent. Fentonium bromide can be used in the research of neurological conditions, such as unstable bladder.
    Fentonium bromide
  • HY-N0110A
    Palmatine
    Palmatine is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC50s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC50 of 96 μM. Palmatine shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities.
    Palmatine
Cat. No. Product Name / Synonyms Application Reactivity
mAChR Isoform Comparison

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