Liposome

Liposomes (NPs typically 100–500 nm in diameter) are fabricated from the self-assembly of phospholipids, which consist of a polar phosphate head group and hydrophobic lipid tails. In aqueous environments, the hydrophobic tails self-orient, resulting in a spherical structure comprised of an aqueous core surrounded by a lipophilic bilayer membrane. Liposomes are both biocompatible and biodegradable (e.g., at certain pH and temperature), which can be controlled by modifying the lipid composition. Furthermore, liposomes are amenable to various modifications that improve their efficacy as drug delivery carriers.

References:

[1]. Almeida B, Nag OK, Rogers KE, Delehanty JB. Recent Progress in Bioconjugation Strategies for Liposome-Mediated Drug Delivery. Molecules. 2020;25(23):5672. Published 2020 Dec 1. [Content Brief]

Liposome Related Products (839):

By Effects:	Controls (2) Inhibitor (1) Substrate (1) Modulator (1) Chemicals (8)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-W339838

1-Myristoyl-2-hydroxy-sn-glycero-3-PG sodium		99.0%
1-Myristoyl-2-hydroxy-sn-glycero-3-PG sodium is a lysophospholipid containing myristic acid (14:0) at the sn-1 position. It has been used in the generation of micelles, liposomes, and other types of artificial membranes, including lipid-based drug carrier systems.

HY-W441016

DSPE-PEG-NHS, MW 5000
DSPE-PEG-NHS, MW 5000 is a PEG-modified phospholipid derivative that can be used to prepare liposomes. DSPE-PEG-NHS, MW 5000 is commonly employed as a linker molecule for the surface modification of liposomes to confer targeting capabilities. DSPE-PEG-NHS, MW 5000 can be used in the study of drug delivery.

HY-145505

1-Oleoyl-2-hydroxy-sn-glycero-3-PG sodium		99.0%
1-Oleoyl-2-hydroxy-sn-glycero-3-PG (18:1 Lyso PE) sodium is a lysophospholipid containing oleic acid (18:1) at the sn-1 position. It can be used in the generation of micelles, liposomes, and other types of artificial membranes, including lipid-based drug carrier systems.

HY-145799A

5A2-SC8 TFA	Chemical	98.56%
5A2-SC8 TFA is an ionizable amino lipid in lipid nanoparticles (LNPs) that shows high delivery potential and low in vivo toxicity, enabling efficient delivery of small RNAs such as siRNA and miRNA into tumor cells. 5A2-SC8 TFA LNPs can confer a unique delivery fate of RNA within the liver, thereby changing the therapeutic outcomes in cancer models.

HY-115435

1,2-Dimyristoyl-sn-glycero-3-phospho-L-serine sodium		98.0%
1,2-Dimyristoyl-sn-glycero-3-phospho-L-serine sodium is an anionic phospholipid with myristic acid tails (14:0) and contains a carboxylic acid (COOH) and amine (NH2) in their head group. It has been used in the preparation of liposome.

HY-120991

1-Palmitoyl-2-linoleoyl-sn-glycero-3-PE		≥98.0%
1-Palmitoyl-2-linoleoyl-sn-glycero-3-PE (1-Palmitoyl-2-linoleoyl PE) is a lipid, which promotes nucleic acid such as sRNA to absorb and enter the target cell.

HY-W440916

DSPE-PEG-FITC (MW 3400)
DSPE-PEG-FITC, MW 3400 is a fluorescein attached PEG lipid. It can be used to prepare liposomes as drug carrier in targeted drug delivery. The polymer is modified with fluorescein (green) dye which can be used for staining cells, tissues, biomarkers, or nanoparticles.

HY-W405064

11-Mercaptoundecanoate-NHS		≥98.0%
11-Mercaptoundecanoate-NHS is a lipid that can be used for the synthesis of Linker.

HY-W590681

113-O12B		99.63%
113-O12B is a disulfide bond-containing ionizable cationic lipidoid. 113-O12B can be used in that generation of lipid nanoparticles (LNPs) for the delivery of mRNA.

HY-145539

12-Dipalmitoyl-sn-glycero-3-PS sodium salt		99.00%
12-Dipalmitoyl-sn-glycero-3-PS sodium salt is an anionic diacyl phospholipid, a lipid component in cell membrane. 12-Dipalmitoyl-sn-glycero-3-PS sodium salt can be use in the preparation of catanionic vesicles and liposome.

HY-141615

1,2-Dipalmitoyl-sn-glycero-3-phospho-N,N-dimethylethanolamine		99.0%
1,2-Dipalmitoyl-sn-glycero-3-phospho-N,N-dimethylethanolamine has been used in the generation of liposomes and monolayers for use in the study of membrane permeability and monolayer viscosity, respectively.

HY-150242A

Cbz-Ala-Ala-Asn TFA		99.54%
Cbz-Ala-Ala-Asn TFA is a peptide that designed based on the sequence of the substrate of legumain. Legumain is a cysteine protease. Cbz-Ala-Ala-Asn TFA can be applied as a scaffold for drug delivery.

HY-144005

C16 PEG2000 Ceramide		99.37%
C16 PEG2000 Ceramide is a polyethylene glycolylated ceramide. C16 PEG2000 Ceramide can be used for lipid carrier to delivery. C16 PEG2000 Ceramide induces autophagy. C16 PEG2000 Ceramide can be used for cancer research.

HY-143210

Transfectam		98.0%
Transfectam is a cationic lipid able to interact with DNA to form complexes that mediate efficient gene transfer into various eukaryotic cells.

HY-W040193S

DSPC-d₇₀		99.0%
DSPC-d₇₀ (1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d₇₀) is the deuterium labeled DSPC (HY-W040193). DSPC is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system.

HY-W590683

9A1P9		99.40%
9A1P9 is a multi-tail ionizable cationic phospholipid. 9A1P9 induces membrane destabilization. 9A1P9 can be used for mRNA delivery t.

HY-W800793

16:0 Succinyl PE		99.34%
16:0 Succinyl PE is a carboxylic acid-functionalized lipid with a two carbon linker to a phosphoethanolamine bound to two palmitic acid tails.

HY-W440981

SPPC		99.96%
SPPC is a phospholipid with different length of fatty acid. The sn-1 position contains a stearic acid (18:0) while the sn-2 position is occupied by a palmitic acid (16:0).

HY-145739

ATX-0114		98.00%
ATX-0114 is an ionizable cationic lipid.

HY-153373

4A3-Cit		98.04%
4A3-Cit is an ionizable lipid used for the generation of lipid nanoparticles (LNPs).

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