Isotope-Labeled Compounds

Isotope-labeled compounds are chemical substances in which some atoms in their molecules are replaced by isotope atoms. The range of stable isotope products can cover from gases to complex molecules. Isotope-labeled compounds could provide a site-specific investigation of structures, making molecules easily detectable by mass spectrometry and NMR, and maintaining the physico-chemical properties of the target molecule at the same time. MCE isotope-labeled compounds are all stable isotope-labeled compounds and are non-radioactive labeled substances. MCE isotope-labeled compounds are unique tools for identifying and understanding biological and chemical processes. Stable isotope-labeled products are now getting more and more popular among scientists. The scope of application is gradually penetrating into various scientific fields, such as life sciences, food and medicine, agriculture, environment, geology, etc. Stable isotope-labeled compounds have a wide range of applications in the Life Science areas, such as Metabolomics, Proteomics, Clinical studies, Deuterium drugs, etc.

Isotope-Labeled Compounds Inhibitors (4)

Isotope-Labeled Compounds Related Products (9980):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-113486S

(S)-Lathosterol-d₄		99.70%
(S)-Lathosterol-d₄ is the deuterium labeled (S)-Lathosterol. Lathosterol is a cholesterol-like molecule. Serum Lathosterol concentration is an indicator of whole-body cholesterol synthesis.

HY-167587S

1-Heptadecanoyl-2-eicosatrienoyl-sn-glycero(-d₅)-3-phosphocholine
1-Heptadecanoyl-2-eicosatrienoyl-sn-glycero(d₅)-3-phosphocholine is deuterium labeled 1-Heptadecanoyl-2-eicosatrienoyl-sn-glycero-3-phosphocholine.

HY-W779193

2-Amino-3-methyl-3H-imidazo[4,5-f]quinoline-2-¹³C
2-Amino-3-methyl-3H-imidazo[4,5-f]quinoline-2-¹³C is ¹³C labeled 2-Ammo-3-memyl-imidazo-[4,5-f]-quinoIine. 2-Ammo-3-memyl-imidazo-[4,5-f]-quinoIine is a mutagenic compound.

HY-W654156

Diclazuril-¹³C₃,¹⁵N₂
Diclazuril-¹³C₃,¹⁵N² is ¹³C and ¹⁵N labeled Diclazuril. Diclazuril (R-64433), a benzeneacetonitrile derivative, is a potent and orally active anticoccidial agent. Diclazuril can be used for the research of certain infectious and parasitic diseases, including coccidiosis, acute toxoplasmosis, equine protozoal pyoencephalitis (EPM) et.al.

HY-105182S1

Xanomeline-d₃
Xanomeline-d₃ (LY-246708-d₃) is deuterium labeled Xanomeline. Xanomeline, as an effective and selective muscarinic type 1 and type 4 (M1/M4) receptor agonist, increases neuronal excitability. Xanomeline can be used for the research of neurological disorders, such as schizophrenia.

HY-118759S

DSP Crosslinker-d₈
DSP Crosslinker-d₈ is the deuterium labeled DSP Crosslinker. Radioactive isotopes labeled compounds can be used in metabolic analysis, allowing the movement of individual atoms to be precisely tracked and quantified.

HY-165698S

Flupyrsulfuron-methyl-d₆ sodium
Flupyrsulfuron-methyl-d₆ (sodium) is deuterium labeled Flupyrsulfuron-methyl (sodium).

HY-15448S1

Tezacaftor-d₆
Tezacaftor-d₆ (VX-661-d₆) is deuterium labeled Tezacaftor. Tezacaftor (VX-661) is a F508del CFTR corrector. It helps CFTR protein reach the cell surface. However, Ivacaftor (VX-770, HY-13017), a CFTR potentiator, helps to prolong the opening time of cell surface CFTR protein channels. Tezacaftor combining with Ivacaftor, shows potent efficacy against cystic fibrosis and diseases with homozygous for the CFTR Phe508del mutation. Moreover, Elexacaftor (VX-445, HY-111772) is also a CFTR corrector. Elexacaftor-Tezacaftor-Ivacaftor aims at with cystic fibrosis (CF) with at least one Phe508del mutation, often avoids the indication for lung transplantation.

HY-B0368S1

Captopril-¹³C₅,¹⁵N
Captopril-¹³C₅,¹⁵N (SQ 14225-¹³C₅,¹⁵N) is ¹³C and ¹⁵N labeled Captopril. Captopril (SQ 14225), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC₅₀=0.025 μM) and has been widely used for research of hypertension and congestive heart failure. Captopril is also a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC₅₀ of 7.9 μM.

HY-Y1630S

NSC 10281-d₄		98.85%
NSC 10281-d₄ is the deuterium labeled NSC 10281.

HY-W142647S

2,2'-Dihydroxy-4,4'-dimethoxybenzophenone-d₆
2,2'-Dihydroxy-4,4'-dimethoxybenzophenone-d₆ (Bis(2-hydroxy-4-methoxyphenyl)methanone-d₆) is deuterium labeled 2,2'-Dihydroxy-4,4'-dimethoxybenzophenone.

HY-100977S

Dimethoxycurcumin-d₆
Dimethoxycurcumin-d₆ is the deuterium labeled Dimethoxycurcumin (HY-100977). Dimethoxycurcumin is a derivative of Curcumin that has anti-inflammatory and antioxidant activities.

HY-103252S1

Monomethyl fumarate-d₅
Monomethyl fumarate-d₅ is deuterium labeled Monomethyl fumarate (HY-103252). Monomethyl fumarate, an active metabolite of Dimethyl fumarate (DMF) (HY-17363), is a potent GPR109A agonist. Monomethyl fumarate has the potential for multiple neuroprotective pathways and other models of retinal disease.

HY-32329S

Setiptiline-d₃
Setiptiline-d₃ is the deuterium labeled Setiptiline. Setiptiline (Org-8282) is a serotonin receptor antagonist. Setiptiline is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). Setiptiline acts as a norepinephrine reuptake inhibitor, α2-adrenergic receptor antagonist, and serotonin receptor antagonist, likely at the 5-HT2A, 5-HT2C, and/or 5-HT3 subtypes, as well as an H1 receptor inverse agonist/antihistamine.

HY-W015778S

2-Methoxy-5-methylphenol-d₃
2-Methoxy-5-methylphenol-d₃ is deuterated labeled 2-Methoxy-5-methylphenol.

HY-173102S

LQEEIDAVL(Pro-¹³C₅,¹⁵N)NK TFA
LQEEIDAVL(Pro-¹³C₅,¹⁵N)NK TFA is the ¹³C- and ¹⁵N-labeled LQEEIDAVL(Pro)NK TFA.

HY-W654335

Rivastigmine-d₄ tartrate
Rivastigmine-d₄ (tartrate) is deuterium labeled Rivastigmine (tartrate). Rivastigmine tartrate (ENA 713; SDZ-ENA 713) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC₅₀s of 0.037 μM, 4.15 μM, respectively. Rivastigmine tartrate can pass the blood brain barrier (BBB). Rivastigmine tartrate is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease.

HY-136081AS

Hexamidine-d₁₂ dihydrochloride
Hexamidine-d₁₂ (dihydrochloride) is the deuterium labeled Hexamidine dihydrochloride.

HY-10019S2

Varenicline-¹³C_,¹⁵N
Varenicline-¹³C¹⁵N (CP 526555-¹³C¹⁵N) is ¹³C and ¹⁵N labeled Varenicline. Varenicline (CP 526555) is an orally active partial agonist of α4β2 nicotinic acetylcholine receptor (α4β2 nAChR, IC₅₀ = 250 nM), which is the principal mediator of nicotine dependence. Varenicline is also a partial agonist of α6β2 nAChR and a full agonist of α7β2 nAChR. Varenicline blocks the direct agonist effects of nicotine on nAChR while stimulates nAChR in a more moderate way, being widely used as an aid of smoking cessation.

HY-W144021S

1-Hexen-3-one-d₃
1-Hexen-3-one-d₃ is deuterated labeled 1-Hexen-3-one.

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