Isotope-Labeled Compounds

Isotope-labeled compounds are chemical substances in which some atoms in their molecules are replaced by isotope atoms. The range of stable isotope products can cover from gases to complex molecules. Isotope-labeled compounds could provide a site-specific investigation of structures, making molecules easily detectable by mass spectrometry and NMR, and maintaining the physico-chemical properties of the target molecule at the same time. MCE isotope-labeled compounds are all stable isotope-labeled compounds and are non-radioactive labeled substances. MCE isotope-labeled compounds are unique tools for identifying and understanding biological and chemical processes. Stable isotope-labeled products are now getting more and more popular among scientists. The scope of application is gradually penetrating into various scientific fields, such as life sciences, food and medicine, agriculture, environment, geology, etc. Stable isotope-labeled compounds have a wide range of applications in the Life Science areas, such as Metabolomics, Proteomics, Clinical studies, Deuterium drugs, etc.

Isotope-Labeled Compounds Inhibitors (3)

Isotope-Labeled Compounds Related Products (9852):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-W700137

2-Aminobutanoic-4,4,4 acid hydrochloride-d₃
2-Aminobutanoic-4,4,4 acid hydrochloride-d₃ is the deuterium labeled 2-Aminobutanoic-4,4,4 acid hydrochloride.

HY-W013863S

Djalonensone-d₃
Djalonensone-d₃ is a deuterium labeled Djalonensone (HY-W013863). Djalonensone, isolated from the roots of Anthocleista djalonensis (Loganiaceae), is an important taxonomic marker of the plant species.

HY-143858S

Nitrosotetracaine-d₆
Nitrosotetracaine-d₆ is the deuterium labeled Nitrosotetracaine.

HY-17412S

Minocycline-d₆ hydrochloride
Minocycline-d₆ hydrochloride is deuterated labeled Minocycline hydrochloride (HY-17412). Minocycline hydrochloride is an orally active, potent and BBB-penetrated semi-synthetic tetracycline antibiotic. Minocycline hydrochloride is a hypoxia-inducible factor (HIF)-1α inhibitor. Minocycline hydrochloride shows anti-cancer, anti-inflammatory, and glutamate antagonist effects. Minocycline hydrochloride reduces glutamate neurotransmission and shows neuroprotective properties and antidepressant effects. Minocycline hydrochloride inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, resulting in a bacteriostatic effect.

HY-W707656

Aspirin-d₇
Aspirin-d₇ is the deuterium labeled Aspirin (HY-14654). Aspirin (Acetylsalicylic acid) is an orally active, potent and irreversible inhibitor of cyclooxygenase COX-1 and COX-2, with IC₅₀ values of 5 and 210 μg/mL, respectively. Aspirin induces apoptosis. Aspirin inhibits the activation of NF-κB. Aspirin also inhibits platelet prostaglandin synthetase, and can prevent coronary artery and cerebrovascular thrombosis.

HY-W757743

Acalabrutinib-d₃
Acalabrutinib-d₃ (ACP-196-d₃) is the deuterated form of Acalabrutinib (HY-17600). Acalabrutinib (ACP-196) is an orally active, irreversible, highly selective second-generation BTK inhibitor. Acalabrutinib covalently binds to Cys481 in the ATP-binding pocket of BTK. Acalabrutinib shows strong targeting and efficacy in mouse models of chronic lymphocytic leukemia (CLL).

HY-113420S2

11-Dehydro-thromboxane B2-¹³C₅
11-Dehydro-thromboxane B2-¹³C₅ is ¹³C labeled 11-Dehydro-thromboxane B2 (HY-113420). 11-Dehydro-thromboxane B2 is a platelet hemagglutinin. Thromboxane inhibition was assessed by urinary excretion levels of 11-Dehydro-thromboxane B2. 11-Dehydro-thromboxane B2 can be used in the study of atherosclerotic thrombosis.

HY-B1260S1

Cetrimonium-d₃₃ bromide
Cetrimonium-d₃₃ bromide is the deuterium labeled Cetrimonium bromide. Cetrimonium bromide (CTAB) is an amine based cationic quaternary surfactant, is one of the components of the topical antiseptic Cetrimide.

HY-W392933S2

Thymidine 5'-monophosphate-¹⁵N₂ dilithium
Thymidine 5'-monophosphate-¹⁵N₂ (Thymidine-5'-phosphate-¹⁵N₂) dilithium is ¹⁵N labeled Thymidine 5'-monophosphate (HY-W392933).

HY-W753956

Iminostilbene-d₁₀
Iminostilbene-d₁₀ is the deuterium labeled Iminostilbene (HY-N7064). Iminostilbene is a chemical precursor of carbamazepine. Additionally, Iminostilbene is an orally active inhibitor of PKM2 (Pyruvate Kinase M2) and COX2 (Cyclooxygenase-2). Iminostilbene exerts its effects by inhibiting PKM2 and its interaction with HIF-1α and STAT3, reducing COX2 and iNOS expression, and decreasing LPS-induced release of IL-1β, IL-6, TNF-α, and MCP-1, thereby suppressing macrophage-mediated inflammatory responses and improving myocardial ischemia/reperfusion (MI/R) injury. Iminostilbene holds promise for research in inflammation regulation, cardiovascular diseases (such as MI/R injury), and macrophage-mediated immune-related diseases.

HY-W114255S

4-Methyl-2-pentanamine-d₅ hydrochloride
4-Methyl-2-pentanamine-d₅ (hydrochloride) is deuterium labeled 4-Methylpentan-2-aminehydrochloride.

HY-W040185S

(R)-2,3-Bis(tetradecanoyloxy)propyl phosphate-d₅₄ sodium		99.3%
(R)-2,3-Bis(tetradecanoyloxy)propyl phosphate-d₅₄ (sodium) is deuterium labeled (R)-2,3-Bis(tetradecanoyloxy)propyl phosphate.

HY-12355S

Siponimod-d₁₁
Siponimod-d11 is deuterium labeled Siponimod (HY-12355). Siponimod is an orally active and selective sphingosine-1-phosphate (S1P) receptor modulator. Siponimod is selective for S1P₁ and S1P₅ over S1P₂, S1P₃, and S1P₄, with EC₅₀s of 0.4, 0.98, >10000, >1000, and 750 nM, respectively. Siponimod can be used for multiple sclerosis (MS) research.

HY-21953S

3-Dehydroxy Chlorthalidone-d₄
3-Dehydroxy Chlorthalidone-d₄ is the deuterium labeled 3-Dehydroxy Chlorthalidone[1].

HY-W727814

Pipendoxifene-d₁₀
Pipendoxifene-d₁₀ (ERA-923-d₁₀) is the deuterium labeled Pipendoxifene (HY-13724). Pipendoxifene is a selective estrogen receptor modulator (SERM).

HY-B0512S1

Sulfamerazine-¹³C₆
Sulfamerazine-¹³C₆ (RP2632-¹³C₆) is ¹³C labeled Sulfamerazine (HY-B0512). Sulfamerazine (RP-2632) is a sulfonamide antibacterial. Sulfamerazine, the monomethyl derivative of sulfadiazine, is 2-sulfanilamido-4-methylpyrimidine. Sulfamerazine is a sulfonamide drug that inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA) for binding to dihydropteroate synthesizes.

HY-W014423S8

L-Histidine-¹⁵N₃,d₅ hydrochloride hydrate
L-Histidine-¹⁵N₃,d₅ hydrochloride hydrate is the deuterium and ¹⁵N labeled L-Histidine hydrochloride hydrate (HY-W014423). L-Histidine hydrochloride hydrate is an endogenous metabolite. L-Histidine hydrochloride hydrate scavenges hydroxyl radicals and singlet oxygen, regulate the absorption of zinc, copper and iron, exhibits anti-inflammatory and antioxidant activities. L-Histidine hydrochloride hydrate is blood brain barrier penetrable.

HY-146837S

C18(plasm)-18:1 PE-d₉
C18(plasm)-18:1 PE-d₉ is deuterium labeled C18(plasm)-18:1 PE.

HY-W016773S

1,10-Decanediol-d₂₀
1,10-Decanediol-d₂₀ is the deuterium labeled 1,10-Decanediol.

HY-W744370

Raloxifene 6-β-D-glucuronide-d₄ lithium
Raloxifene 6-β-D-glucuronide-d₄ lithium is the deuterium labeled Raloxifene 6-β-D-glucuronide lithium.

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