2. Others Immunology/Inflammation Anti-infection Apoptosis NF-κB MAPK/ERK Pathway Autophagy
  3. Autophagy NF-κB p38 MAPK Mitophagy Caspase Apoptosis Virus Protease Isotope-Labeled Compounds COX
  4. Aspirin-d7

Aspirin-d7 is the deuterium labeled Aspirin (HY-14654). Aspirin (Acetylsalicylic acid) is an orally active, potent and irreversible inhibitor of cyclooxygenase COX-1 and COX-2, with IC50 values of 5 and 210 μg/mL, respectively. Aspirin induces apoptosis. Aspirin inhibits the activation of NF-κB. Aspirin also inhibits platelet prostaglandin synthetase, and can prevent coronary artery and cerebrovascular thrombosis.

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Aspirin-d<sub>7</sub> Chemical Structure

Aspirin-d7 Chemical Structure

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Aspirin-d7 Related Antibodies

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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COX COX-1 COX-2 COX-3

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Description

Aspirin-d7 is the deuterium labeled Aspirin (HY-14654). Aspirin (Acetylsalicylic acid) is an orally active, potent and irreversible inhibitor of cyclooxygenase COX-1 and COX-2, with IC50 values of 5 and 210 μg/mL, respectively. Aspirin induces apoptosis. Aspirin inhibits the activation of NF-κB. Aspirin also inhibits platelet prostaglandin synthetase, and can prevent coronary artery and cerebrovascular thrombosis[1][2][3][4][5][6].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Aspirin-d7 Related Antibodies
Molecular Weight

187.20

Formula

C9HD7O4
Unlabeled CAS
SMILES

O=C(OC1=C(C([2H])=C(C([2H])=C1[2H])[2H])C(O)=O)C([2H])([2H])[2H]
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Aspirin-d7 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aspirin-d7AutophagyNF-κBp38 MAPKMitophagyCaspaseApoptosisVirus ProteaseIsotope-Labeled CompoundsCOXNuclear factor-κBNuclear factor-kappaBMitochondrial AutophagyCyclooxygenaseInhibitorinhibitorinhibit

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