Insecticide

Insecticides refer to any toxic substances used to kill insects, which exert toxic effects on pests through different mechanisms, thereby achieving the purpose of controlling pest populations and protecting crops and human health. Insecticides have both chemical and biological origins and can be classified into organochlorine insecticides, organophosphorus insecticides, carbamate insecticides, and mineral insecticides based on their chemical properties. Insecticides interact with different target and non-target sites, including receptors, enzymes, and many other known and unknown molecules. Most insecticides are neurotoxicants that target the nervous system, but they can also affect other organs and body systems. Insecticides are metabolized through different metabolic pathways and often serve as biomarkers of exposure in the form of their parent compounds or metabolites. The toxicity of insecticides can be acute, subacute, or chronic, depending on the duration of exposure and the dose involved. Therefore, selecting sensitive, accurate, and validated biomarkers of exposure, effects, and susceptibility appears to be a challenging task.
Insecticides are widely used in agriculture, horticulture, forestry, gardening, homes, offices, and other fields^[1]^[2].

References:

[1]. Sparks TC. Insecticide discovery: an evaluation and analysis. Pestic Biochem Physiol. 2013 Sep;107(1):8-17. [Content Brief]

[2]. Gupta R C, et al. Insecticides[M]//Biomarkers in toxicology. Academic Press, 2019: 455-475.

Insecticide Related Products (349):

By Effects:	Inhibitors (27) Activator (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-B2009S

Flufenoxuron-d₃
Flufenoxuron-d₃ is the deuterium labeled Flufenoxuron (HY-B2009). Flufenoxuron is a chitin synthesis inhibitor that is used as a benzoylurea insecticide. Flufenoxuron decreases chitin synthesis, molting, and egg hatching, preventing development in insects.

HY-B0819R

Phoxim (Standard)
Phoxim (Standard) is the analytical standard of Phoxim. This product is intended for research and analytical applications. Phoxim is an organic phosphorus pesticide and widely applies worldwide for agricultural purposes.

HY-N3097R

Pellitorine (Standard)
Pellitorine (Standard) is the analytical standard of Pellitorine (HY-N3097). Pellitorine is a bioactive natural amide compound. Pellitorine can competitively antagonize the activation of TRPV1 by Capsaicin (HY-10448), thereby reducing pain signal transmission. Pellitorine improves cognitive dysfunction by upregulating the BDNF-ERK1/2-CREB and Nrf2-HO-1 pathways. Pellitorine exerts anti-inflammatory and anti-sepsis effects by inhibiting the release of high mobility group protein B1 (HMGB1) and the expression of RAGE/TLR4. Pellitorine exerts its antithrombotic effect by prolonging the clotting time, inhibiting the activity of clotting factors and thrombin. Pellitorine inhibits lipid peroxidation and resists ferroptosis by upregulating GPX4 and DHODH. Pellitorine kills Aedes aegypti mosquito larvae by inhibiting V-type H⁺-ATPase and aquaporin 4 (AaAQP4). Pellitorine exhibits anti-cancer activity (e.g., leukemia and breast cancer) and has inhibitory effects on certain bacteria.

HY-N0073A

Spirostan-3-ol
Spirostan-3-ol is a useful tool to keep bees away from areas recently treated with toxic insecticides.

HY-114899

Azamethiphos
Azamethiphos is an organophosphate insecticide that inhibits AChE. Azamethiphos inhibits sea lice.

HY-B0916S

Propoxur-d₃
Propoxur-d₃ is the deuterated form of Propoxur (HY-B0916). Propoxur is a reversible, competitive, orally active AChE inhibitor that can cross the blood-brain barrier. Propoxur inhibits AChE activity to induce neurotoxicity, while promoting MMP-2 expression and enhancing tumor cell migration and invasion by inducing intracellular ROS generation and activating the ERK/Nrf2 signaling pathway. On the one hand, Propoxur inhibits AChE, leading to acetylcholine accumulation and causing neurological dysfunction; on the other hand, it promotes Nrf2 nuclear translocation through ROS-dependent ERK1/2 phosphorylation, and upregulates MMP-2 and other invasion-related proteins. Propoxur is also a carbamate insecticide used to combat turf, forestry, and household pests.

HY-177745

25-Azacoprostane
25-Azacoprostane (5β-Cholan-24-dimethylamine) is an azasteroid. 25-Azacoprostane has significant inhibitory activity against the molting and metamorphosis processes of various insects. 25-Azacoprostane can be used as insecticide.

HY-W753485

Profenofos-d₃
Profenofos-d₃ is the deuterium labeled Profenofos (HY-B0832). Profenofos is an insecticida used on field crops, vegetables, and fruit crops. Profenofos is an acetylcholinesterase (AChE) inhibitor, with neurotoxicity.

HY-114899R

Azamethiphos (Standard)
Azamethiphos (Standard) is the analytical standard of Azamethiphos (HY-114899). This product is intended for research and analytical applications. Azamethiphos is an organophosphate insecticide that inhibits AChE. Azamethiphos inhibits sea lice.

HY-132457S

Fenthion-d₆
Fenthion-d₆ is a deuterium labeled Fenthion. Fenthion is an organophosphorus insecticide.

HY-122996

Nikkomycin M
Nikkomycin M is used as an insecticide.

HY-176042

Insecticidal agent 22
Insecticidal agent 22 (Compound A13) is an insecticide, with LC₅₀s of 1.4 and 9.9 μg/mL for diamondback moth (Plutella xylostella) and fall armyworm (Spodoptera frugiperda), respectively. Insecticidal agent 22 can be used as a low-toxicity alternative to Fluralaner (HY-16973).

HY-123519

14α-Hydroxy Paspalinine	Inhibitor
14α-Hydroxy Paspalinine is a paspalinine derivative with antiinsectan activity from the sclerotia of Aspergillus nomius.

HY-P1882

Type A Allatostatin I
Type A Allatostatin I is a tridecapeptide. Allatostatins are pleiotropic neuropeptides for inhibition of juvenile hormone synthesis in insects.

HY-145494

Thiuram disulfide	Inhibitor
Thiuram disulfide is a pesticide. The absorbance is measured at 435 nm.

HY-172794

Insecticidal agent 23	Inhibitor
Insecticidal agent 23 (compound 17) has antischistosomal efficacy and low toxicity. Insecticidal agent 23 exhibits potent in vitro activity against adult S. japonicum, with an LC₅₀ (72 h) value of 25.31 μM.

HY-W758414

Phoxim-d₅ (phenyl-d₅) (mixture of isomers)
Phoxim-d₅ (phenyl-d₅) (mixture of isomers) is the deuterium labeled Phoxim (HY-B0819). Phoxim is an organic phosphorus pesticide and widely applies worldwide for agricultural purposes.

HY-W587768

Metoxadiazone
Metoxadiazone is a type of insecticide that effectively controls a wide range of insects, including cockroaches and ants. Metoxadiazone exerts its insecticidal effect by impacting the nervous system of insects. Metoxadiazone can be used for research into its potential toxicity to humans and other non-target organisms.

HY-157192

Clothianidin-2-S-propanoic acid
Clothianidin-2-S-propanoic acid is a clothianidin hapten. Clothianidin-2-S-propanoic can be used for the research of insecticide.

HY-B1984S

p,p'-DDD-d₈	Inhibitor
p,p'-DDD-d₈ is the deuterium labeled p,p'-DDD[1]. p,p'-DDD (4,4’-DDD) is an organochlorine insecticide, a major metabolite of p,p'-DDT. p,p'-DDD is an agonist at estrogen receptor α(ERα) and ERβ. p,p'-DDD increases DNA damage, apoptosis and necrosis in peripheral blood. p,p'-DDD stimulates cell proliferation in SKBR3 cells. p,p'-DDD activates the AP-1 transcription factor. p,p'-DDD decreases sleep times of barbiturates and steroids in rats.

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