2. Signaling Pathways
  3. Immunology/Inflammation
  4. IKZF Family

IKZF Family

Ikaros zinc finger protein family

IKZF family is a group of transcription factor families that play a crucial role in processes such as lymphopoiesis, differentiation, and functional regulation of lymphocytes. The proteins of its members have specific zinc finger domains in their structures, which can interact with DNA or other proteins, thus regulating the gene transcription process. As transcriptional repressors and activators, members of the IKZF family are of great significance in the differentiation of hematopoietic stem cells into lymphocytes, as well as in the differentiation and function exertion of T and B cells. In addition, members of the IKZF family can regulate gene expression through various mechanisms, including remodeling chromatin structure, promoting the activity of the RNA Pol II transcription initiation complex, and inducing chromosome conformational changes, etc. Mutations or abnormal functions of the members of the IKZF family are associated with a variety of diseases, such as B cell deficiency, leukemia, and autoimmune diseases[1].

IKZF Family Isoform Specific Products:

IKZF Family Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-175040
    PROTAC FLT-3 degrader 5
    		Degrader
    PROTAC FLT-3 degrader 5 is a FLT3 PROTAC degrader (DC50 = 1.2 nM). PROTAC FLT-3 degrader 5 functions as a molecular glue to degrade cereblon substrates GSPT1 and IKZF1/3. PROTAC FLT-3 degrader 5 exhibits antiproliferative activity against drug-resistant acute myeloid leukemia (AML) cells and is potentially useful in AML research. (Pink: FLT3/GSPT1/IKZF1/3 ligand: (HY-169374); Blue: Thalidomide: (HY-14658); Black: linker; Thalidomide + linker: (HY-W1123823)).
    PROTAC FLT-3 degrader 5
  • HY-160533
    IKZF1-degrader-2
    		Degrader
    IKZF1-degrader-2 (Compound 3) is an IKZF1 molecular glues degrader. IKZF1-degrader-2 has anticancer activity and low toxicity.
    IKZF1-degrader-2
  • HY-W1128213
    IKZF2-degrader 2
    		Degrader
    IKZF2-degrader 2 is a selective and orally active IKZF2 molecular glue degrader with DC50 values of 0.5 nM and 1.8 nM in HiBit and FACS. The IKZF2-degrader 2 mediates the ubiquitination and degradation of target proteins by recruiting the CRL4-CRBN E3 ubiquitin ligase. IKZF2-degrader 2 displays moderate degradation against SALL4 with a DC50 of 9 nM but does not induce any significant degradation towards IKZF1, IKZF3, CK1α and GSPT1. IKZF2-degrader 2 can be used for the study of cancer immunology.
    IKZF2-degrader 2
  • HY-175602
    TM-04-064-02
    		Degrader
    TM-04-064-02 is a molecular glue degrader. TM-04-064-02 induces proteins (such as IKZF1/3, PPIL4, ETF1 and PDE6D) to bind to CRBN, promoting their ubiquitination and degradation.
    TM-04-064-02
  • HY-172882
    IKZF2-degrader 1
    		Degrader
    IKZF2-degrader 1 (Compound 31) is a IKZF2 molecular glue degrader, with an DC50 of 0.5 nM. IKZF2-degrader 1 has minimal CK1α degradation activity relatively (DC50: 210 nM). IKZF2-degrader 1 can be used for research of IKZF2-dependent cancers.
    IKZF2-degrader 1
  • HY-175600
    MI-2-80
    		Degrader
    MI-2-80 is a molecular glue degrader. MI-2-80 induces proteins (such as IKZF1/3 and CSNK1A1) to bind to CRBN, promoting their ubiquitination and degradation.
    MI-2-80
  • HY-172368
    PROTAC CARM1/IKZF3 degrader-1
    		Degrader
    PROTAC CARM1/IKZF3 degrader-1 (Compound 074) inhibits CARM1, reduces the methylation level of its substrate BAF155. PROTAC CARM1/IKZF3 degrader-1 is the PROTAC degrader for IKZF 1/3 through a CRBN-dependent pathway. PROTAC CARM1/IKZF3 degrader-1 inhibits the expression of MYC protein, thereby inhibiting the proliferation of a variety of multiple myeloma cells. PROTAC CARM1/IKZF3 degrader-1 induces apoptosis in cell H929. PROTAC CARM1/IKZF3 degrader-1 overcomes immunomodulatory drugs (IMiD, such as pomalidomide) resistance. PROTAC CARM1/IKZF3 degrader-1 can be used in cancer and immunology research. (Pink: ligand for target protein CARM1/IKZF3 ligand 1 (HY-172369); Active form of target protein ligand: EZM 2302 (HY-111109); Black: linker (HY-21999); Blue: ligand for E3 ligase Cereblon Thalidomide 4-fluoride (HY-41547))
    PROTAC CARM1/IKZF3 degrader-1
  • HY-160531
    IKZF1-degrader-1
    		Degrader
    IKZF1-degrader-1 (Compound 9-B) is a IKZF1 molecular glue degrader with the DC50 value of 0.134 nM. IKZF1-degrader-1 can be used to degrader tumors.
    IKZF1-degrader-1
IKZF Family Isoform Comparison

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