2. Signaling Pathways
  3. Anti-infection
  4. HPV

HPV

Human papillomavirus

Human papillomavirus (HPV) is the most common sexually transmitted infection (STI) that commonly causes skin or mucous membrane growths (warts). HPV is a virus with double-stranded circular DNA from the papillomavirus family. All HPVs have icosahedral capsids. HPV displays tropism toward the epithelial basal layer, which houses adult epithelial stem cells responsible for replenishing the epithelium with daughter cells. There are more than 100 varieties of human papillomavirus (HPV). Some types of HPV infection cause warts, and some (HPV 16 and 18) can cause different types of cancer, including cancers of the anus, penis, vagina, vulva and back of the throat (oropharyngeal). Worldwide, the risk of being infected at least once in a lifetime among both men and women is 50%. Vaccines can help protect against the strains of HPV most likely to cause genital warts or cervical cancer.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-14741
    Epetirimod
    		Inhibitor
    Epetirimod (S-30563; TAK-851) is an immune-response modifier, that ameliorates the cervical human papilloma virus (HPV) infection and cervical dysplasia.
    Epetirimod
  • HY-146033
    HPV18-IN-1
    		Inhibitor
    HPV18-IN-1 (Compound H1) is a potent inhibitor of HPV18. HPV18-IN-1 prevents cervical cancer cells from premature cell procession and abnormal proliferation. HPV18-IN-1 supresses E7-Rb-E2F cellular pathway and DNA methylation. HPV18-IN-1 has the potential for the research of cancer diseases.
    HPV18-IN-1
  • HY-P10428
    E6AP-mimicking peptide
    		Inhibitor
    E6AP-mimicking peptide (compound 13) is a high-affinity, selective, irreversible and potent peptide-based covalent HPV16 E6 inhibitor targeting the 16E6 oncoprotein using a cysteine-reactive acrylamide warhead. E6AP-mimicking peptide has a Ki of 17 nM. E6AP-mimicking peptide targets all residues appearing in the binding pocket of E6 to disrupt the binding interface of 16E6 and E6AP. E6AP-mimicking peptide selectively binds and crosslinks to MBP-16E6 in PBS or a protein mixture.
    E6AP-mimicking peptide
  • HY-15733R
    Lucidin (Standard)
    		Inhibitor
    Lucidin (Standard) is the analytical standard of Lucidin. This product is intended for research and analytical applications. Lucidin (NSC 30546) is a natural component of madder and can induce mutations in bacterial and mammalian cells.
    Lucidin (Standard)
  • HY-119151
    GS-9191
    		Inducer
    GS-9191 is the prodrug of the nucleotide analog PMEG. GS-9191 is a topical agent to permeate skin and be metabolized to the active nucleoside triphosphate analog in the epithelial layer. GS-9191 inhibits NA synthesis, arrests cell in S phase, and induces cell apoptosis. GS-9191 can be used for research of human papillomaviruses (HPV) infection.
    GS-9191
  • HY-P2299
    Protein E7(43-62)
    Protein E7(43-62) is an E7-derived peptide with anti-tumor effects (short peptide spanning the 43th to 62th amino acid residues in the E7 protein).
    Protein E7(43-62)
  • HY-P1778
    HPV16 E7 (86-93)
    HPV16 E7 (86-93) is a human leukocyte antigen (HLA)-A2.1 restricted HPV16 E7-derived peptide. HPV16 E7 (86-93) is immunogenic in cervical carcinomas.
    HPV16 E7 (86-93)
  • HY-P5694
    Human α-defensin 5
    		Inhibitor
    Human α-defensin 5 is an antiviral peptide. Human α-defensin 5 blocks infection of non-enveloped viruses, including AdV, HPV, and polyomaviruses (IC50: 0.6-1.25 μM for HPV16). Human α-defensin 5 can bind to the viral capsid and blocks escape of the virus from the endosome. Human α-defensin 5 increases HIV binding to the cell surface. Human α-defensin 5 also has parasiticidal activity.
    Human α-defensin 5
  • HY-P1881
    HPV16-E711-20 epitope
    HPV16-E711-20 epitope is a well-known HLA-A*0201-restricted human cytotoxic T lymphocyte (CTL) epitope of the HPV16 E7 protein that shows high-affinity binding to HLA-A2 in vitro. HPV16 CTL epitopes may be good candidates for the development of an effective peptide-based antitumor vaccine.
    HPV16-E711-20 epitope
  • HY-101795R
    Larixyl acetate (Standard)
    		Inhibitor
    Larixyl acetate (Standard) is the analytical standard of Larixyl acetate. This product is intended for research and analytical applications. Larixyl acetate is a potent and selective TRPC6 inhibitor with IC50 values of 0.58 μM and 6.83 μM against hTRPC6-YFP and hTRPC3-YFP, respectively. Larixyl acetate prevents HPV and is effective in protecting against traumatic brain injury-induced systemic endothelial dysfunction.
    Larixyl acetate (Standard)
  • HY-129253
    GSK984
    		Control
    GSK984 is an inactive control probe for GSK983 (HY-119098), a dihydroorotate dehydrogenase (DHODH) inhibitor with antiviral activity.
    GSK984
  • HY-107801R
    Inosine pranobex (Standard)
    		Inhibitor
    Inosine pranobex (Standard) is the analytical standard of Inosine pranobex. This product is intended for research and analytical applications. Inosine pranobex is an orally active immunomodulator. Inosine pranobex has broad-spectrum antiviral activity. Inosine pranobex inhibits human immunodeficiency virus (HIV), herpes simplex virus (HSV), vaccinia virus (VACV), human tumor virus (HPV), Cytomegalovirus, influenza virus (INFV), parainfluenza virus (PIV), and Epstein-Barr virus .
    Inosine pranobex (Standard)
  • HY-120599A
    Sabizabulin hydrochloride
    		Inhibitor
    Sabizabulin hydrochloride is a potent orally bioavailable microtubule inhibitor with activity that interacts with the colchicine binding site. Sabizabulin hydrochloride demonstrated significant inhibition of melanoma tumor growth with an average IC50 of 5.2 nM in melanoma and prostate cancer cell lines. Pharmacological screening of Sabizabulin hydrochloride shows it has a low risk of potential side effects.
    Sabizabulin hydrochloride
Cat. No. Product Name / Synonyms Species Source