1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. HPPD

HPPD

4-Hydroxyphenylpyruvate dioxygenase

4-Hydroxyphenylpyruvate dioxygenase (HPPD) is an Fe(II)-dependent, non-heme oxygenase that catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate. HPPD catalyzes the second step in the pathway for the catabolism of tyrosine, that is common to essentially all aerobic forms of life. In plants this pathway has an anabolic branch from homogentisate that forms essential isoprenoid redox cofactors such as plastoquinone and tocopherol.he transformation catalyzed by HPPD has both agricultural and therapeutic significance

HPPD Related Products (7):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B0607
    Nitisinone
    99.69%
    Nitisinone is an orally active, competitive and reversible 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor with an IC50 of 173 nM. Nitisinone promotes tyrosine accumulation in a dose-dependent manner. nitisinone can be used in studies of hereditary tyrosinemia type 1 (HT-1) (a rare genetic disorder) and albinism.
    Nitisinone
  • HY-118742
    Benzobicyclon
    99.25%
    Benzobicyclon is a 4-HPPD inhibitor and herbicide that reacts with water to form a hydrolysate of the active herbicide benzobicycline, causing bleaching and death of weeds. Benzobicyclon is effective against grass, sedge and broadleaf weeds. Benzobicyclon effectively targets sulfonylurea herbicide-resistant biotypes as well as wild-type weeds.
    Benzobicyclon
  • HY-155135
    HPPD-IN-1
    Inhibitor
    HPPD-IN-1 (compound II-3) is a HPPD inhibitor. HPPD-IN-1 shows inhibitory activity of Arabidopsis thaliana HPPD (AtHPPD) with an IC50 value of 0.248 μM, which was superior to that of mesotrione (HY-12853) (0.283 μM) in vitro. HPPD-IN-1 shows excellent herbicidal activity against broadleaf and monocotyledonous weeds.
    HPPD-IN-1
  • HY-111957
    Fenquinotrione
    Fenquinotrione is a 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor with IC50s of 27.2 and 44.7nM against rice and Arabidopsis thaliana HPPD, respectively. Fenquinotrione is an herbicide that can control a wide range of broadleaf and sedge weeds with excellent rice selectivity.
    Fenquinotrione
  • HY-161308
    HPPD-IN-3
    Inhibitor
    HPPD-IN-3 (compound 25) is a potent inhibitor of 4-Hydroxyphenylpyruvate dioxygenase (HPPD), with IC50 of 10 nM, more potency than Mesotrione (HY-12853).
    HPPD-IN-3
  • HY-163559
    HPPD-IN-4
    Inhibitor
    HPPD-IN-4 (Compound III-29) is a selective inhibitor of HPPD with anIC50 of 0.19 μM. HPPD-IN-4 is primarily used in the study of high-efficiency herbicides.
    HPPD-IN-4
  • HY-155465
    HPPD-IN-2
    Inhibitor
    HPPD-IN-2 (compound 28) is a herbicide based on HPPD inhibitors. HPPD-IN-2 potently targets AtHPPD and exhibits enhanced safety in canola crops.
    HPPD-IN-2